Journal of Cellular Immunology and Serum Biology
Canine Pluripotent Stem Cells: Preclinical Model for Stem Cell Based Regenerative Medicine
Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, School of Medicine, Yale University, USA
Jiesi Luo, Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut, USA, E-mail: email@example.com
Luo, J. Canine Pluripotent Stem Cells: Preclinical Model for Stem Cell Based Regenerative Medicine. (2017) Cell Immunol Serum Biol 3(1): 87- 92.
© 2017 Luo, J. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
KeywordsPluripotent stem cells; Embryonic stem cells; Blastocysts
Due to the unique similarity to human physiology, biochemistry, and pathology for many diseases, canine breeds have been applied to preclinical research into human medicine for several decades. Since 2006, the discovery of induced pluripotent stem cell technology set the stage for the patient specific stem cell-based therapy. To evaluate the safety and efficacy of this potential therapeutic strategy, a growing body of studies on the generation and differentiation of canine induced pluripotent stem cells (ciPSCs) have been reported. In this review, the current progress from the ciPSCs studies will be described. Additionally, the unique regulatory mechanism(s) for pluripotency maintenance with in canine pluripotent stem cells will be discussed and compared with those in mouse and human.