Cellular Responses in Titanium Dioxide Nanoparticle Cytotoxicity Studies: Parts of the Map Waiting to be Composed
Shunbang Yu1, Joanna Bohatko-Naismith1, Xudong Zhang2, Xiaonan Zhou3, Pu Wang4, He Wang1*
Affiliation
- 1School of Health Sciences, University of Newcastle, Callaghan, NSW 2308, AUSTRALIA
- 2School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW 2308, AUSTRALIA
- 3School of Nursing, Peking Union Medical College, Beijing 100144, CHINA
- 4School of Clinical, Baotou Medical College, Baotou, Inner Mongolia Autonomous Region 014040, CHINA
Corresponding Author
Yu, S., School of Health Sciences, University of Newcastle, Callaghan, NSW 2287, Australia, E-mail: c3220962@uon.edu.au
Citation
He Wang., et al. Cellular Responses in Titanium Dioxide Nanoparticle Cytotoxicity Studies: Parts of the Map Waiting to be Composed. (2017) J Med Chem Toxicol 2(2): 62- 70.
Copy rights
© 2017 Yu, S. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
Keywords
Abstract
With the infiltration of nanotechnology into our daily life, exposure to Titanium Dioxide Nanoparticles (TNPs) has become inevitable. Many forms of exposures are capable of affecting the human health. Current research in the Titanium dioxide nanoparticle pathology field reveals that TNP is capable of inducing severe oxidative stress to in vivo and in vitro cells, which predominantly result in cellular apoptosis. This article summarizes the main pathways of TNP induced apoptosis and compares it with cigarette-smoke-induced senescence, in an attempt to identify the similarities and acknowledge knowledge gaps to question the integrity of the TNP cytotoxicity studies conducted. The viable cells in the studies reviewed are not defined, and may provide a direction for future TNP toxicology studies.
