Comparing of pro-inflammatory cytokines in the woman with preterm and term labors.
Keyvan Ghadimi1,2*, Ali Danaeiniya3.
Affiliation
1School of Medicine, Guilan University of Medical Sciences, Guilan, Iran
2Iranian pregnant women association department, beheshti Hospital, Isfahan, Iran
3Physiology Department, Isfahan Payam-e-noor University, Isfahan, Iran
Corresponding Author
Nazli Sadat Meshinchi Asl, School of Medicine, Guilan University of Medical Sciences, Guilan, Iran, Tel: + 98 912 230 0516/ Postal Code: 7346181746; E-mail: Nazlimeshinchi@yahoo.com
Citation
Meshinchi Asl, N.S., et al. Preterm Ovarian Hyperstimulation Syndrome: A Clinical Presentation of Three Cases. (2018) J Gynecol Neonatal Biol 4(1): 22- 26.
1School
Copy rights
© 2018 Meshinchi Asl, N.S. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
Keywords
Abstract
Background: Preterm birth is one of the most important issues in obstetrics medicine and yet, the leading cause of morbidity and long-term disabilities such as neuro developmental impairments. There have been many studies trying to recognize responsible factors and develop new methods to predict and cure the condition. One important factor in preterm birth is immune system and immune factors such as cytokines. In this regard, we aimed to measure different cytokines in sera of mothers experiencing preterm birth.
Methods and Materials: In this case control study, we measured serum levels of IL-2, IL-4, IL-5, IL-6, IL-7, IL-8 (CXCL8), IL-10, IL-12(p70), IL-13, interferon gamma (IFN-g), granulocyte macrophage colony stimulating factor (GMC-SF) and TNF-alpha in women with preterm and term labors according to Enzyme-Linked Immune Sorbent Assay (ELISA).
Results: Serum levels of IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-13 and TNF-α in preterm group were significantly higher than control group (P < 0.05, for all). Also, GMC-SF serum levels in the preterm group were significantly lower than control group (P < 0.0001).
Conclusion: here in this study we indicated that immune system and pro-inflammatory cytokine have been change in preterm birth and further examinations on more patients may create new insights in developing methods to predict and prevent the disease.