Journal of Veterinary Science and Animal Welfare
Determination of Oxytetracycline Absorption and Effectiveness against Aeromonas salmonicidain Rainbow Trout (Oncorhynchus mykiss)
- 1Office of New Animal Drug Evaluation, Center for Veterinary Medicine, Food and Drug Administration, USA
- 2Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, USA
- 3Aquatic Pathobiology Laboratory, Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, USA
- 4Office of Research, Center for Veterinary Medicine, Food and Drug Administration, USA
Ron A. Miller, Office of New Animal Drug Evaluation, Center for Veterinary Medicine, Food and Drug Administration, 7500 Standish Place Rockville, MD 20855, USA, Tel: 240-402-0795; E-mail: email@example.com
Miller, R.A., et al. Determination of Oxytetracycline Absorption and Effectiveness against Aeromonas salmonicidain Rainbow Trout (Oncorhynchus mykiss). (2016) J Vet Sci Animal Welf 1(1):1- 9.
© 2016 Miller, R.A. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
KeywordsOxytetracycline; Furunculosis; Aeromonas salmonicida; Oncorhynchus mykiss
This study determined the effectiveness and oral absorption of oxytetracycline (OTC) in rainbow trout (Oncorhynchus mykiss) experimentally infected with an Aeromonas salmonicida challenge strain (MIC = 0.25 μg/mL). The FDA-approved OTC-medicated feed regimen was shown to be highly efficacious. A follow-up parallel study revealed a clear and direct correlation between serum OTC and serum total protein (TP) concentrations in A. salmonicida-challenged rainbow trout 1, 3, 4, 6, and 10 days after medicated dosing began. Mean serum OTC concentrations collected at various time points during the dosing regimen were lower in A.salmonicida-challenged rainbow trout than previously shown in healthy uninfected trout.