Journal of Medicinal Chemistry and Toxicology
Effect of steroidal saponins-loaded composite scaffolds on bone healing
Department of Chemistry, Mekelle University College of Natural and Computational Science, Ethiopia
Teklit Gebregiorgis Amabye, Department of Chemistry, Mekelle University College of Natural and Computational Science, Ethiopia; E-mail: email@example.com
Amabye, T.G. Effect of Steroidal Saponins-Loaded Composite Scaffolds on Bone Healing. (2016) J Med Chem Tox 1(1): 18- 21.
© 2016 Amabye, T.G. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
KeywordsSteroidal saponins; Scaffold; Sustained release; Bone tissue engineering
The objective of this study was to investigate the therapeutic potential of nano-bioglass/phosphatidylserine/collagen scaffolds loaded with steroidal saponins as an inducer factor for skeletal defects. The drugs-encapsulated bone substitute was prepared by loading steroidal saponins-collagen microsphere suspension in nano-bioglass and phosphatidylserine composite. The scaffolds possess an interconnected porous structure with a porosity of about 82.3%. The pore size ranges from several micrometers up to about 400 μm. The drug release assays showed the long-term sustained release of steroidal saponins from the scaffolds with effective and safe bioactivity. Moreover, in vitro and in vivo studies showed that the involvement of steroidal saponins contributed to the secretion of nerve growth factor in MC3T3-E1 cells, which may be the possible factor that greatly enhanced bone healing. The results suggest that the bone substitute is an effective implantable drug-delivery system for use in bone repair.