Journal of Medicinal Chemistry and Toxicology
Effects of Carbohydrates on the Toxicity of p-Aminophenyl Arsenoxide against S. cerevisiae
- 1Hubei Co-Innovation Center for Utilization of Biomass Waste, China
- 2Hubei Key Laboratory of Biomass-Resource Chemistry and Environmental Biotechnology, China
- 3Hubei Key Laboratory of Quality Control of Characteristic Fruits and Vegetables, College of Chemistry and Materials Science, Hubei Engineering University, China-432000
Qin, C., et al. Effects of Carbohydrates on the Toxicity of p-Aminophenyl Arsenoxide against S. cerevisiae. (2017) J Med Chem Toxicol 2(1): 28- 33.
© 2017 Qin, C. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
Keywordsp-Aminophenyl arsenoxide; Carbohydrates; Toxicity; Trimer; S.cerevisiae; Microcalorimetry
The effects of carbohydrates on the toxicity of p-Aminophenyl arsenoxide (p-APAO) against S. cerevisiae were investigated by Microcalorimetry, including glucose, fructose, lactose, sucrose, N-acetyl glucosamine, 1,3,4,6-tetra-O-acetyl-D-glucosamine (OADG), and chito-oligomer. The toxicity of p-APAO on S. cerevisiae decreased in the presence of OADG or chito-oligomer. Among the test carbohydrates, the antagonism of OADG was better than those of other sugars. These results suggested that OADG and chito-oligomer were p-APAO antagonists. Carbohydrates could form complex with p-APAO to prohibit p-APAO from polymerizing. This result was attributable to hexose carriers not recognizing the p-APAO effectively.