Following the Natural History of A Probable Adrenoleukodystrophy Case and Literature Review
Ana Carolina Andorinho de Freitas Ferreira1, André Palma Matta1, Karina Magalhães de Castro Henriques1, Osvaldo JM Nascimento1, Arielle Kirmse1, Cristina de Almeida Pereira1, Joao Dib1, Henrique Cal1, Marco Antonio Araújo Leite1, Jano Alves de Souza1, Pedro Morales1, Marco Orsini3*
Affiliation
- 1Federal Fluminense University, HUAP, Neurology Department, Niterói, Rio de Janeiro, Brazil
- 2Federal Fluminense University, HUAP, Patology Department,Niterói, Rio de Janeiro, Brazil
- 3Masters Program in Science Rehbiitation, UNISUAM, Neuroscience Department, Bonsucesso, Rio de Janeiro, Brazil
Corresponding Author
Marco Orsini, Masters Program in Science Rehabitation, UNISUAM, Neuroscience Department, Bonsucesso,Rio de Janeiro, Brazil. E-mail: orsinimarco@hotmail.com
Citation
Orsini, M., et al. Following the Natural History of a Probable Adrenoleukodystrophy( 2015) Int J Neurol Brain Disord 2(2): 1- 4.
Copy rights
© 2015 Orsini, M. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
Keywords
Abstract
Leukodystrophies compass a wide range of genetic disorders that compromise the white matter. Some of them exhibit different phenotypes with late and slow onset. The present work reports an unusual case of probable X-Linked Adrenoleukodystrophy that could be classified in adrenomyeloneupathy, but there were no signs of adrenal insufficiency and the cognitive decline developed fast. MRI evinced classical symmetrical parieto-occipital pattern of lesion, although dosage of very long chain fatty acids was normal.
