Journal of Addiction and Dependence
Highdose of buprenorphine in the treatment of refractory major depression with severe suicidal tendencies
Professor of Psychiatry, Founder and Director, Substance Abuse resaerch center, Shiraz University of Medical Sciences
Jamshid Ahmadi, Professor of Psychiatry, Founder and Director, Substance Abuse Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, Tel: 98-71-36279319, E-mail: Jamshid_Ahmadi@yahoo.com
Ahmadi, J. High Dose of Buprenorphine in the Treatment of Refractory Major depression with Severe Suicidal Tendencies. (2017) J Addict Depend 3(1): 1- 3.
© 2017 Ahmadi, J. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
KeywordsRefractory depression; Suicidal tendencies; Buprenorphine
Background: Administration of high dose buprenorphine is associated with rapid-acting anti-depressive and ant-suicidal effects.
Objective: To examine the effect of high dose buprenorphine on the refractory major depression with severe suicidal tendencies.
Method: In the current study we tested the competency of buprenorphine for the treatment of depression and suicide.
Results: High dose buprenorphine was resulted to fast treatment of refractory depression and suicide. Moreover, promotion in psychoactivity, high demotion in depression, regulation of emotion and mood, were observed following buprenorphine administration. Buprenorphine was well tolerated as well.
Discussion: Our results illuminated that buprenorphine has rapid and sustained antidepressive potentials. These findings should be replicated in randomized, placebo-controlled, double-blind trials.
Conclusion: This report indicated that a single high dose of buprenorphine appears to be clinically effective and safe. Our study advises that a single high dose buprenorphine can provide a speedy, simple and safe means of treatment of depression and suicide. Usage of a single high dose of buprenorphine appears to concerns about compliance, and also to diminish the chance of buprenorphine being diverted for abuse.
As yet fast-acting and sustained antidepressive effects of a high dose of buprenorphinehave not been printed, hence this result could be a significant addition to the literature.