Journal of Clinical Trials, Pathology and Case Studies
Impaired Aerobic Performance with Low-Affinity Hemoglobinopathy
Departments of Medicine and Physiology, UCLA David Geffen School of Medicine, Los Angeles, California
Gerard, W. Frank, M.D., Ph.D., Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, California, E-mail: GFrank@mednet.ucla.edu
Frank, G.W., et al. Impaired Aerobic Performance with Low-Affinity Hemoglobinopathy. (2016) Clin Trials Pathol Case Stud 1(1): 1- 2.
© 2016 Frank, G.W. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
A patient of Asian extraction was found to have 16% Hemoglobin Titusville, which has decreased affinity for oxygen. The patient underwent a maximal exercise test revealing impaired aerobic performance which can be explained by adverse effects on oxygen uptake in the lungs, reduced arterial oxygen content and impaired oxygen delivery to tissues.