International Journal of Hematology and Therapy
Liver Pancreas Heart Triangle and HCV in Thalassemia: Expanding the Horizon through Biomarker Networks
Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy
Cristina Vassalle, PhD, Fondazione G.Monasterio CNR-Regione Toscana Via Moruzzi 1, I-56124, Pisa, Italy, Tel: 39-050-3153525; Fax: 39-050-3152166, E-mail: email@example.com
Vassalle, C., et al. Liver-Pancreas- Heart Triangle and HCV in Thalassemia: Expanding the Horizon through Biomarker Networks. (2017) Int J Hematol Ther 3(1): 1- 6.
© 2017 Vassalle, C. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License
KeywordsLiver; Pancreas; Heart; Bone; Thalassemia major; Biomarkers
Magnetic Resonance Imaging represents the elective strategy to assess iron overload in different organs and drives the iron chelation therapy in Thalassemia major (TM). However, affected organs, in particular liver, pancreas and heart, are not isolated but interact each other and communicate through biochemical mediators, which may accelerate and worsen pathological processes considered unrelated. A better understanding of these intermingled pathways might help to identify more significant biomarker combinations and the association of these biomarkers to TM complexity, possibly assisting imaging techniques in the prevention of complications and in the improvement of life quality in TM patients