International Journal of Food and Nutritional Science
Omega-3 Fatty Acids Improve Lipid Metabolism and Inflammatory Markers in Patients with Heart Failure Undergoing Exercise Training
1Post-Graduation Program in Nutrition of the Federal University of Santa Catarina, Florianopolis, Florianopolis-SC, Brazil
2Post-Graduation Program in Science of Human Movement of the State University of Santa Catarina, Florianopolis-SC, Brazil
3Lipid Metabolism Laboratory, Heart Institute (InCor) of the University of São Paulo Medical School, Sao Paulo-SP, Brazil
4Department of Clinical Analyses, Federal University of Santa Catarina, Florianopolis- SC, Brazil
Edson Luiz da Silva, Department of Clinical Analysis, Health Sciences Center, Federal University of Santa Catarina, Campus, s/n, Trinity, 88.040-370, Florianópolis, SC, Brazil. Telephone: 55-48-3721-97.12; Fax: 55-48-3721-5072; E-mail:firstname.lastname@example.org; email@example.com
da Silva, E. L. et al. Omega-3 Fatty Acids Improve Lipid Metabolism and Inflammatory Markers in Patients with Heart Failure Undergoing Exercise Training. (2015) J Food Nutr Sci 2(1): 70-75.
© 2015 da Silva, E. L. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
KeywordsHeart failure; Omega-3 PUFA; Exercises training, Lipid profile; Inflammatory markers
We hypothesize whether omega-3 (n-3) polyunsaturated fatty acids (PUFA) supplementation may improve the lipid metabolism and inflammatory biomarkers in heart failure (HF) patients undergoing exercise training. Sixteen male patients, who were participating in a physical cardiac rehabilitation program, ingested 4.8 g of fish oil daily (2.51 g of eicosapentaenoic and docosahexaenoic acids) for 60 days. Blood samples were collected at baseline and after 60 days of n-3 PUFA supplementation for analysis. The paired Student t-test was applied to detect differences (p < 0.05). The n-3 PUFA significantly reduced the levels of triglyceride (28.9%), small dense LDL- cholesterol (16.2%), non-HDL-cholesterol (9.0%), and TNF-α (17.8%) after 60 days (p < 0.05). Furthermore, the transfer of cholesteryl-ester to HDL increased by 23.1% (p < 0.05). In summary, the n-3 PUFA supplementation improved the lipid metabolism and low-grade systemic inflammation in HF patients submitted to exercise training, which may lower the risk of cardiovascular events.