International Journal of Hematology and Therapy
Personalized Targeted Prevention and Therapy Relied on Detection of Global and Local Single Nucleotide Polymorphisms
Department of Pediatrics, Children Hospital, Augusta, USA
Li, B. Department of Pediatrics, Children Hospital, Augusta, USA. E-mail: BLI@gru.edu
Li, B. et al. Personalized Targeted Prevention and Therapy Relied on Detection of Global and local single Nucleotide Polymorphisms (2015) Int J Hematol and Therap 1(1): 1-8.
© 2015 Li, B. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
KeywordsGenome-wide association studies (GWAS); single nucleotide polymorphisms (SNP); transcriptome; Encyclopedia of DNA Elements (ENCODE); flow-cytometric cell sorting (FACS); magnetic cell separation (MACS); Laser-captured micro-dissection (LCM); clinical genomics analysis and diagnosis; system biology and system modeling, networks; personalized medicine; personalized target therapy.
Personalized medicine, one of special prevention and therapeutic strategies, is going to develop into clinical fields. Personalized medicine is directly tailored for physicians to prevent and care individual patient. It is often called as "the right treatment for the right person at the right time." Most successful examples of personalized prevention and treatments require a rational clinical genomic analysis. Following Research and Development (R&D) of clinical genomic techniques, here we introduce personalized targeted-therapy based on either detection of single nucleotide polymorphisms (SNP) or detection of universal single nucleotide variance (SNVs) at genomic level. According to clinical protocol of personalized targeted prevention and therapy, whole performance includes clinical sampling, SNP detection technology and diagnosis (universal and designed), SNP signature discovered by system modeling and sensitive targeted molecules/drugs uncovered by drug-banks with its confirmation. Now, after (A) simplified and designed SNP detection test is applied for clinical patients and (B) next generation sequencing for universal SNP detection is brought into the new field, both universal and designed SNP detection systems related with sensitive targeted molecules will make great contribution for further personalized prevention and treatment of tumor diseases, genetic diseases and uncured disease in nerve, endocrine and cardiovascular systems.