Journal of Gynecology & Neonatal Biology
Prevalence of Rhesus c and e Phenotype Among Pregnant Women Attending Antenatal Clinic in Usmanu Danfodiyo University Teaching Hospital, Sokoto.
- 1Department of Haematology and Blood Transfusion, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University Sokoto, Nigeria
- 2Department of Haematology and Blood Transfusion, Usmanu Danfodiyo University Teaching Hospital Sokoto, Nigeria
- 3Department of Obstetrics and Gynaecology Usmanu Danfodiyo University Teaching Hospital Sokoto, Nigeria
Erhabor O, Department of Haematology and Blood Transfusion, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University Sokoto, Nigeria, E-mail: email@example.com
Erhabor, O., et al. Prevalence of Rhesus C And E Phenotype Among Pregnant Women Attending Antenatal Clinic In Usmanu Danfodiyo University Teaching Hospital, Sokoto. (2016) J Gynecol Neonatal Biol 2(1): 13-16.
© 2016 Erhabor, O. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
KeywordsRhesus; Antigen c; Antigen e; Pregnant women; Sokoto; Nigeria
Rhesus (Rh) antigen was discovered in 1940 by Karl Landsteiner and Wiener. In later years, because of its immunogenicity along with ABO antigens, Rh D antigen testing was made mandatory before issuing a compatible blood. Presently there are five major Rh antigens (D, C, E, c and e) in the Rh blood group system. The aim is this study is to determine the prevalence of Rh c and e phenotype among pregnant women attending antenatal clinic (ANC) in Usmanu Danfodiyo University Teaching Hospital Sokoto. The prevalence and distribution of Rh c and e phenotype was determined among 200 consecutively recruited pregnant women aged 18-45 years and mean age 27.19 ± 4.72 years. Samples were tested for Rh c and e phenotype using the conventional tube agglutination method using Lorne Laboratories (UK) anti c and e antisera. Out of 200 samples studied, the prevalence of Rh c was 92% while Rh e was 98.5%. We observed a statistically significant ethnic variation in the distribution of Rh c and e antigens among the pregnant subjects (p = 0.05 and 0.02) respectively. The prevalence of Rhesus c and e antigens was significantly higher among the Hausa ethnic group compared to the other ethnic groups. A significant number of antenatal attendees were better educated with secondary and tertiary education compared to those with primary and non-formal education. We recommend that all pregnant women in the area be screened for the presence of clinically significant red cell antigens including Rh c and e blood group antigens on their first antenatal visit. There is need to introduce routine alloantibody screening for clinically significant red cell antibodies to facilitate the effective management of anti-c and e related haemolytic disease of the foetus and newborn as well as to prevent haemolytic transfusion reactions. Policy should be developed to facilitate optimum stocking of c and e negative cell in blood bank for emergency use in the area.