Affiliation

Department of Hematology, Lanzhou General Hospital, Lanzhou Command, Lanzhou, Gansu, 730050, China

Corresponding Author

Dr. Tao Wu, Department of Hematology, Lanzhou General Hospital, Lanzhou Command, 333 South Binhe Rd, Lanzhou, Gansu, 730050, China, Tel: +86-13919939297/ Fax: +86-931-2665486; E-mail: wutaozhen@yeah.net

Citation

Wu, T., et al. Primary Cutaneous  CD30 (-) Anaplastic Large Cell Lymphoma: A Rare Case Report. (2017) Int J Hemat Ther 3(3): 1- 3.

Copy rights

© 2017 Wu, T. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.

Keywords

Abstract

  Primary cutaneous anaplastic large cell lymphoma (PC-ALCL) is a rare type of non-Hodgkin’s lymphoma comprising approximately 0.9 - 9.0% of all cutaneous lymphomas. 75% of them are CD30 positive. PCALCL is characterized by the absence of systemic involvement, spontaneous regression and low recurrence rate especially in localized lesions.
  We present a 33-year-old male with a 1-year history of asymptomatic, well-defined, systemic involvement, diameter of 2 - 6 cm, irregularly-shaped erythematous plaques. Skin punch biopsy revealed dense infiltrates of non-epidermotropic, large, irregularly-shaped lymphocytes with hyperchromatic and pyknotic nuclei. Immunohistochemistry revealed that these atypical cells are CD3(+), CD5 dispersion (+), CD20(- ), CD79a(-), Ki-67(-), TdT(-), CD10(-), Bcl-6(-), CyclinD1(-), CD138 dispersion (+), MUM1(-), mitochondrial enzymes B(+), TIA-1(+++), CD4(++), CD8 dispersion(+), CD30(-), CD56(-). Clinical, histopathological and immunohistochemical findings are consistent with PC-ALCL. Regular VELP (Vincristine, Etoposide, L-Asaraginase, and Prednisone) chemotherapy resulted in total resolution of skin lesions.
  Because the clinical presentation of PC-ALCL can be variable, a high index of suspicion is necessary in patients presenting with chronic plaques and nodules unresponsive to topical or oral medications.