Protective effect of Lyciumbarbarum extract as Antioxidant Agent on Roridin A Induced Hepatotoxicity in Male Rat
Nagwa M. Elsawi1*, Madeha N. Alseeni2, Hala I. Madkour3, Doha S Mohamed4, Asma. S.Abdo1
Affiliation
- 1Department of Chemistry, Faculty of Science, Sohag University, Sohag, Egypt
- 2Department of Biochemistry, Faculty of Science, King Abdel-Aziz University, Jaddah, Saudi Arabia
- 3Department of Pharmacology, Faculty of Medicine, Sohag University, Sohag, Egypt
- 4Department of Histology, Faculty of Medicine, Sohag University, Sohag, Egypt
Corresponding Author
Nagwa M. Elsawi, Department of Chemistry, Faculty of Science, Sohag University, Sohag, Egypt. E-mail: elsawinagwa@yahoo.com
Citation
Elsawi, N. M. et al. Protective Effect of Lycium Barbarum Extract as Antioxidant Agent on Roridin A: Induced Hepatotoxicity in Male Rat. (2015) J Food Nutr Sci 2(2): 81-85.
Copy rights
©2015 Elsawi, N. M.. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
Abstract
The fruit goji berry of Lyciumbarbarym, a traditional Chinese herbal medicine, has been widely used in healthy diets due to its potential role in the prevention of chronic diseases. We studied the effects ofroridin A toxin in male rat liver and their amelioration by goji extract. Thirtymale adult albino rats were divided into three groups (10 rats each). Group 1 (Control group) was given only the solvent(DMSO) of roridin A. Group 2 was administered a single dose (0.6 mg/kg) of rordin A mycotoxin (dissolved in 1% DMSO) for one week. Group 3 was treated prophylactically with goji extract (5 mg/kg) using gastric tube daily for 6 days and left for one week. Roridin A showed a highly significant increase in serum levels of cholesterol, triglycerides and significant increase inglucose, total antioxidants and tumor necrosis factor (TNF). There was significant decrease in serum ferritin level. On the other hand, administration of goji along with rordin A showed a reduction in the above mentioned factors and elevation inferritin level. Histopathological changes in the rat liver coincided with the above biochemical changes. In conclusion; the treatment of rats with goji extract ameliorated the adverse effects of rordin A. Thus, gojimay be used asan antioxidant for certain toxins.
