Journal of Pharmacy & Pharmaceutics
Quinoline Derivatives: In Vitro Antimicrobial Study
- 1Department of Chemistry, Saurashtra University, Rajkot, India
- 2Department of Biosciences, Saurashtra University, Rajkot, India
Shipra Baluja, Department of Chemistry, Saurashtra University, Rajkot, 360005, Gujarat, India, E-mail: email@example.com
Baluja, S., et al. Quinoline Derivatives: In Vitro Antimicrobial Study. (2017) J Pharm Pharmaceutics 4(1): 1-6.
© 2017 Baluja, S. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
KeywordsQuinoline derivatives; Dimethyl sulphoxide; N, N-dimethyl formamide; Gram positive bacteria; Gram negative bacteria; Fungal strains
Some quinoline derivatives were synthesized and their structures were confirmed by IR, 1H NMR and mass spectroscopy. Screening of all these synthesized compounds were done in vitro against four Gram positive bacteria, four Gram negative bacteria and four fungal strains in dimethyl sulphoxide and N, N-dimethyl formamide. It is observed that N, N-dimethyl formamide is good solvent for the these compounds in selected strains and compounds containing cyano and nitro groups are more effective in inhibiting these strains.