International Journal of Hematology and Therapy
Relevance between Helicobacter Pylori Infection and Immune Thrombocytopenia
- 1Department of Medical Microbiology and Immunology, Mansoura Faculty of Medicine, Mansoura, Egypt
- 2 Clinical Hematology Unit, Internal Medicine department, Oncology center, Faculty of Medicine, Mansoura University,Egypt
Dr. Rania Abd El-Hamid El-Kady, Department of Medical Microbiology and Immunology, Mansoura Faculty of Medicine, Mansoura University, Egypt, Tel: 01065608625, E-mail: email@example.com
El-Kady, R.A., et al. Relevance between Helicobacter pylori Infection and Immune Thrombocytopenia. (2017) Int J Hematol Ther 3(2): 1- 6.
© 2017 El-Kady, R.A. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
KeywordsImmune thrombocytopenia; Platelet count; Helicobacter pylori; Eradication therapy; CagA.
Objectives: This study was conducted to determine: [i] the prevalence of Helicobacter pylori (H. pylori) infection in adult patients with immune thrombocytopenia (ITP), [ii] the response of H. pylori infected ITP patients to eradication therapy of H. pylori, [iii] an anticipating factor for platelet response in H. pylori-infected ITP patients.
Methods: The study enrolled 60 adult patients diagnosed with ITP recruited to the Outpatient Clinic of Haematology, Oncology Center of Mansoura University (OCMU), Mansoura, Egypt. H. pylori infection was detected by faecal H. pylori antigen enzyme linked immunosorbent assay (ELISA). Serum H. pylori anti-cytotoxin associated gene A (anti-CagA) IgG titers were assessed by ELISA. ITP patients positive for H. pylori infection received standard eradication regimen.
Results: H. pylori infection was detected in 33.3% of ITP patients. 13 patients (65%) exhibited an increased platelet count safter eradication therapy (treatment responders). The decline in the titers of anti-CagA IgG after therapy was statistically significant in responders (p = 0.005) compared to non-responders (p = 0.1).
Conclusion: H. pylori detection and eradication is recommended in adult patients with ITP, so that farther harsh treatment approaches of ITP could be adverted in infected patients. Moreover, anti-CagA IgG titer is a predictive indicator for platelet recovery after eradication therapy.