Letters in Health & Biological Sciences
Synthesis, Magnetic, Spectral and Antibacterial Properties of Some Metal(II) Complexes of Mixed Drugs, Aspirin and Vitamin B2
Inorganic Chemistry unit, Department of Chemistry, University of Ibadan, Nigeria
Aderoju A. Osowole, Inorganic Chemistry unit, Department of Chemistry, University of Ibadan, Nigeria, Tel: 2348097327529; E-mail: firstname.lastname@example.org
Osowole, A.A., Odutemu, A.E. Synthesis, Magnetic, Spectral and Antibacterial Properties of Some Metal(II) Complexes of Mixed Drugs, Aspirin and Vitamin B2. (2016) Lett Health Biol Sci 1(2): 30- 33.
© 2016 Osowole, A.A. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
KeywordsMetal(II) complexes; Drug designs
Some metal(II) complexes of the mixed drugs-Aspirin and Vitamin B2 (Riboflavin) were synthesized and characterized by melting point, conductance, percentage metal measurements, as well as infrared and electronic spectroscopies. The electronic spectra, percentage metal analysis and conductance measurements corroborated octahedral geometry for all the metal complexes. Infrared data confirmed that metal complexes had O4 chromophores, that is, coordination was via the carbonyl oxygen atoms of the carboxylic acid and acetyl groups of the Aspirin; and hydroxy oxygens in Riboflavin. Furthermore, the room temperature magnetic data suggested that both the Fe(II) and the Ni(II) complexes exhibited spin-crossover, that is, low spin ↔ high spin octahedral equilibrium, while the Mn(II) and Cu(II) complexes exhibited antiferromagnetism respectively. The drugs, Aspirin and Vitamin B2, and their metal(II) complexes were generally inactive against E.coli, Enterobacteria sp, Klebsiella sp, Bacillus sp, Staphylococcus aureus, Pseudomonas sp and Staphylococcus epidermidis, with the exception of Co(II), Ni(II) and Cu(II) complexes which showed some activities against Bacillus sp., Klebsiella sp. and Staphylococcus spp. With inhibitory zones in the range of 6.0 - 12.0 mm respectively.