Synthesis, Physicochemical and Antioxidant Properties of Some Metal(II) Complexes of Mixed Drugs, Aspirin and Nicotinamide
Abiodun E. Odutemu
Affiliation
Inorganic Chemistry unit, Department of Chemistry, University of Ibadan, Nigeria
Corresponding Author
Aderoju A. Osowole, Inorganic Chemistry unit, Department of Chemistry, University of Ibadan, Nigeria, Tel: +2348097327529; E-mail: aderoju30@gmail.com
Citation
Osowole, A.A., Odutemu, A.E. Synthesis, Physicochemical and Antioxidant Properties of Some Metal(II) Complexes of Mixed Drugs, Aspirin and Nicotinamide. (2016) Lett Health Biol Sci 1(2): 37- 42.
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© 2017 Osowole, A.A. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
Keywords
Abstract
The Drugs, Aspirin (HL) and Nicotinamide (HL3), and their mixed metal(II) complexes were synthesized and isolated as [M(HL)(HL3)X2], where M = Fe, Co, Ni, Cu, Zn; X = Cl-/SO42-. These complexes were characterized by spectroscopic techniques (IR & UV-Visible), percentage metal, molar conductance, melting point and room temperature magnetic moment measurements. The metal complexes were mostly non-electrolyte in DMSO with molar conductance values in the range 19.70 - 46.80 Ω-1cm2mol-1. Nicotinamide and Aspirin behaved as bidentate, coordinating to the metal ion through their carbonyl oxygen and pyridinyl nitrogen atoms respectively, as corroborated by infrared spectroscopy measurement. Electronic spectra indicated that all the metal complexes adopted octahedral geometry and magnetic data revealed that the Mn(II) and Ni(II) complexes were probably dimeric, while the remaining metal complexes were monomeric, diamagnetic or paramagnetic. In addition, the antioxidant study revealed that the drugs, Aspirin and Nicotinamide (Vitamin B3), and their mixed metal complexes had higher antioxidant activity than Ascorbic acid, the positive standard, thus confirming their potentials as anticancer agents in-vitro.