Journal of Addiction and Dependence
Three high doses of buprenorphine in the treatment of prolonged and severe opium dependence: a new access
Professor of Psychiatry, Founder and Director, Substance Abuse resaerch center, Shiraz University of Medical Sciences
Jamshid Ahmadi, Professor and Founding Director, Substance Abuse Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, E-mail: Jamshid_Ahmadi@yahoo.com
Ahmadi, J. Three High doses of Buprenorphine in the treatment of prolonged and severe Opium Dependence: A New Access. (2017) J Addict Depend 3(1): 1- 3.
© 2017 Ahmadi, J. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.
KeywordsRefractory depression; Suicidal tendencies; Buprenorphine
Background: Heavy and prolonged opium dependence is a progressing problem in the East. For the treatment of opium dependence, buprenorphine can be prescribed less frequently than daily due to its long half-life.
Objective: To administered three high doses buprenorphine instead of daily use to reduce probability of buprenorphine dependence.
Results: The prescription of three high doses of 32, 96 and 72 mg buprenorphine was tolerated conveniently. Administration of high doses of buprenorphine completely improved opium withdrawal symptoms.
Discussion: The current work indicated that few high doses of buprenorphine, could be adequate and satisfactory for the improvement of heavy and prolonged opium dependence.
Conclusions: We came to this result that administration of high dose buprenorphine looks to be convenient, acceptable and tolerable. More research studies should be of interest as high buprenorphine doses are getting more general clinically. We concluded that three doses of 32, 72 and 96 mg buprenorphine, could be adequate for the improvement of severe opium use disorder.