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Publish Date : 2018-12-17
Journal of Nanotechnology and Materials Science

Assessment of the Effect of Consciousness Energy Healing Treatment on Physicochemical and Thermal Properties of Chromium (VI) Oxide

Snehasis Jana
Alice Branton1, Mahendra Kumar Trivedi1, Dahryn Trivedi1, Gopal Nayak1, Snehasis Jana2*
Article information 

Affiliation

1Trivedi Global Inc, Henderson, USA

2Trivedi Science Research Laboratory Pvt. Ltd, Bhopal, India

Corresponding Author

 Snehasis Jana, Trivedi Science Research Laboratory Pvt Ltd, Bhopal, India, Tel: +91-022-25811234; Email: publication@trivedieffect.com

Citation

Alice Branton., et al. Assessment of the Effect of Consciousness Energy Healing Treatment on Physicochemical and Thermal Properties of Chromium (VI) Oxide. (2018) J Nanotechnol Material Sci 5(1): 68-74.

Copy rights

© 2018 Alice Branton. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License.

Keywords

Chromium trioxide; The Trivedi Effect®; Consciousness energy healing treatment; PXRD; Particle size; Surface area; DSC

Abstract

Chromium TriOxide (CrO3) is an inorganic compound which has many industrial applications, but it is very hygroscopic, toxic and a powerful oxidizer. The objective of this study was to evaluate the impact of the Trivedi Effect® (Consciousness Energy Healing Treatment) on the physicochemical and thermal properties of CrO3 using modern analytical techniques. The CrO3 test sample was separated into two parts. One part of the test samplewas called as a control sample (no Biofield Energy Treatment was provided), while the second part of chromium trioxide sample received the Consciousness Energy Healing Treatment remotely by a well-known Biofield Energy Healer, Alice Branton and termed as a treated sample. The powder XRD peak intensities and crystallite sizes of the treated CrO3 were significantly altered ranging from -63.06% to 357.95% and -41.82% to 420%, respectively; thus, the average crystallite size was significantly increased by 70.46% compared with the control sample. The particle size values of the treated CrO3 were significantly increased by 434.85% (d10), 17.61% (d50), and 19.72% {D(4,3)}, respectively; therefore, the specific surface area was significantly decreased by 80.56% compared with the control.The latent heat of fusion of the treated CrO3 was significantly increased by 33.18% compared with the control sample. The experimental results indicated that the Trivedi Effect® -Consciousness Energy Healing Treatment might include a new polymorphic form of CrO3 which would show better powder flowability and lower solubility. It may lower the absorption, bioavailability and toxicity of CrO3 on inhalation, ingestion, chronic exposure, contact to skin and eye, and aggravation of pre-existing conditions. Along with the Biofield Energy Treated CrO3 would be veryuseful to the manufacturing industry.

Introduction

 

  Chromium (VI) oxide (CrO3) is an inorganic compound. Chemically it is an acidic anhydride of chromic acid[1]. The compound is a dark-purple solid while anhydrous and bright orange when wet or dissolves in water. Chromium trioxide is highly hygroscopic and a powerful oxidiser, which will ignite organic materials on contact[2]. Chromium trioxide is typically employed for chrome plating, which affects the plating process without reacting with the trioxide. It generates passivating chromate films by reacting with zinc, cadmium, and other metals to the resist corrosion[3]. Synthetic rubies manufacture taking chromium trioxide[4]. It is also used aerospace applications and also the preferred stripping agent of anodic coatings[2]. Chromium trioxide is highly corrosive, toxic, and carcinogenic. It causes potential health effects on inhalation, ingestion, contact with the skin and eye, chronic exposure, and aggravation of pre-existing conditions[5]. It was observed that the Trivedi Effect® -Biofield Energy Healing Treatment has a considerable impact on the intrinsic physicochemical properties of various living and non-living objects[6-9]. The Trivedi Effect® is a natural and only scientifically established phenomenon in which an individual can harness this inherently intelligent energy from the “Universe”and transfer it anywhere on the planet through the possible mediation of neutrinos[10]. Every living organism possesses unique para-dimensional electromagnetic field around the body which generated from the continuous movement of the electrically charged particles (ions, cells, etc.) inside the body known as the “Biofield” (Putative Energy Field). Biofield based Energy Healing Therapies have been reported with significant outcomes against various disease conditions[11]. The National Institutes of Health (NIH) and the National Center for Complementary and Alternative Medicine (NCCAM) recommend and included the Energy Therapy under Complementary and Alternative Medicine (CAM) category, which has been accepted by most of the U.S. population with many advantages[12,13]. In this regards, the Consciousness Energy Healing Treatment (the Trivedi Effect®) has been extensively reported with amazing results in the field of agriculture[14,15], biotechnology[16,17], microbiology[18,19], medical science[20,21], material science[22,23], organic chemistry[24,25], and nutraceutical/ pharmaceutical sciences[26,27]. It is also experimentally found altering the bioavailability of pharmaceutical/ nutraceutical compounds[28-30]. Looking at the amazing results of the Trivedi Effect® -Consciousness Energy Healing Treatment on various objects, the current research work has been designed to evaluate the impact of the Trivedi Effect® on chromium trioxide using Powder X-Ray Diffraction (PXRD), Particle Size Analysis (PSA), and Differential Scanning Calorimetry (DSC) analytical techniques.


Materials and Methods

Chemicals and Reagents: The chromium (VI) oxide (CrO3) powder was purchased from Sigma Aldrich, India; however, the additional chemicals used in the experiments were purchased in India.


Consciousness energy healing treatment strategies: The chromium trioxide powder was the test item and divided into two parts. One part of the chromium trioxide sample was considered as a control/untreated sample, which did not provide the Biofield Energy Treatment. Consequently, the second part of the test item was treated with the Trivedi Effect® remotely under standard laboratory conditions for 3 minutes by the renowned Biofield Energy Healer, Alice Branton, USA, and known as the Biofield Energy Treated sample. Moreover, the control sample was treated with a “sham” healer; but, the “sham” healer was ignorant about the Biofield Energy Treatment (the Trivedi Effect®). After the treatment, the treated and untreated chromium trioxide samples were kept in sealed conditions and characterized using spectroscopic and calorimetric analytical techniques.


Characterization

Powder X-ray diffraction (PXRD) analysis: The PXRD analysis of chromium trioxide was performed with the help of Rigaku MiniFlex-II Desktop X-ray diffractometer (Japan)[31,32]. The average size of individual crystallites was calculated from PXRD data using the Scherrer’s formula (1)

G = kλ/βcosθ     (1)

Where k is the equipment constant (0.94), G is the crystallite size in nm, λ is the radiation wave length (0.154056 nm for Kα1 emission), β is the full-width at half maximum (FWHM), and θ is the Bragg angle[33].

The % change in crystallite size (G) of chromium trioxide was calculated using the following equation 2:

Where GControl and GTreated are the crystallite size of the control and Biofield Energy Treated samples, respectively.


Particle Size Analysis (PSA): The particle size analysis of chromium trioxide was performed on Malvern Master sizer 2000, from the UK[34,35]. The % change in particle size (d) was calculated using the following equation 3:

Where dControl and dTreated are the particle size (μm) for at below 10% level (d10), 50% level (d50), and 90% level (d90) of the control and Biofield Energy Treated samples, respectively.

The % change in surface area (S) was calculated using the following equation 4:

Where SControl and STreated are the surface area of the control and Biofield Energy Treated chromium trioxide, respectively.


Differential Scanning Calorimetry (DSC): The DSC analysis of chromium trioxide was performed with the help of DSC Q200, TA Instruments[34,35]]. The % change in melting point (T) was calculated using the following equation 5:

  Where TControl and TTreated is the melting point of the control and treated samples, respectively.

The % change in the latent heat of fusion (ΔH) was calculated using the following equation 6:

  Where ΔHControl and ΔHTreated are the latent heat of fusion of the control and treated chromium trioxide, respectively.


Results and Discussion

Powder X-ray Diffraction (PXRD) Analysis: Many sharp and intense peaks were observed in the PXRD diffractograms of the control and Biofield Energy Treated chromium trioxide (Figure 1), which indicated that both the samples were crystal line. The highest peak intensity of both the samples showed at 2θ equal to 21.3° (Table 1, entry 1). The overall peak intensities of the Biofield Energy Treated chromium trioxide were significantly altered ranging from -63.06% to 357.95% compared with the control sample. Similarly, the crystallite sizes of the treated chromium trioxide were significantly altered ranging from -41.82% to 420.00% compared to the control chromium trioxide. Overall, the average crystallite size of the Biofield Energy Treated chromium trioxide (593.43 nm) was significantly increased by 70.46% compared with the control sample (348.14 nm).


Table 1: PXRD data for the control and Biofield Energy Treated chromium trioxide.

Entry No. Bragg angle (°2θ) Peak Intensity (%) Crystallite size (G, nm)
Control Treated Control Treated % change a Control Treated % change b
1 21.21 21.32 143 148 3.50 435 342 -21.38
2 25.9 26.03 76 50.3 -33.82 297 390 31.31
3 37.3 37.55 8.8 40.3 357.95 130 676 420.00
4 45.18 45.17 6 6.8 13.33 159 416 161.64
5 46.02 46.11 9.4 8.9 -5.32 142 410 188.73
6 67.88 67.08 11.1 4.1 -63.06 265 1333 403.02
7 69.23 69.36 11.1 14.5 30.63 1009 587 -41.82
8 Average crystallite size 348.14 593.43 70.46

adenotes the percentage change in the peak intensity of Biofield Energy Treated sample with respect to the control sample;
bdenotes the percentage change in the crystallite size of Biofield Energy Treated sample with respect to the control sample.


Figure 1: PXRD diffractograms of the control and Biofield Energy Treated chromium trioxide.


  The results indicated significant variations in the crystallite sizes and peak intensities of the Biofield Energy Treated sample compared to the control sample. As per the literature, the peak intensity of any diffraction face on the crystalline compound changes according to the crystal morphology[36], and alterations in the PXRD pattern provide the proof of polymorphic transitions[37,38]. The Biofield Energy Healing Treatment probably produced the new polymorphic form of chromium trioxide with the help of Consciousness Energy via neutrino oscillations[10]. Different polymorphic forms of a compound have significant effects on their physicochemical and thermodynamic properties like melting point, energy, stability, and especially solubility[39,40]. Therefore, it can be assumed that the Trivedi Effect® Treated chromium trioxide would be better to use in the industry as a raw material for the manufacturing.


Particle Size Analysis (PSA): The PSA analysis of both the control and Biofield Energy Treated chromium trioxide were performed and the distribution curves are presented in Figure 2. The particle size distribution curve of the treated chromium trioxide sample was slightly different compared to the control sample (Figure 2). The particle size values of the control chromium trioxide sample at d10, d50, d90, and D(4,3) were 31.61 μm, 278.84 μm, 579.07μm, and 292.76μm, respectively. Similarly, the particle sizes of the treated chromium trioxide at d10, d50, d90, and D(4,3) were 169.07 μm, 327.93 μm, 575.92 μm, and 350.51 μm respectively. Therefore, the particle size values in Biofield Energy Treated chromium trioxide was significantly increased at d10, d50, and D(4,3) by 434.85%, 17.6%, and 19.72%, respectively compared to the control sample. However, at d90 the particle size was slightly decreased by 0.54% in the Biofield Energy Treated sample compared to the control sample. The specific surface area of Biofield Energy Treated chromium trioxide (0.126m2/g) was significantly decreased by 80.56% compared with the control sample (0.025m2/g). Hence, it can be assumed that the Consciousness Energy Healing Treatment might act as an external force for increasing the particle size of the CrO3 sample, hence decreased the surface area. Increased in the particle size of the compound may help in enhancing the appearance, shape, and flow ability of the compound[41,42]. Thus, the Biofield Energy Treatment might improve the powder flow ability, and lower solubility hence lower the absorption, bioavailability, and toxicity of chromium trioxide on inhalation, ingestion, contact to skin and eye, chronic exposure, and aggravation of pre-existing conditions.


Table 2: Particle size distribution of the control and Biofield Energy Treated chromium trioxide.

Parameter d10 (μm) d50 (μm) d90 (μm) D(4,3)(μm) SSA (m2/g)
Control 31.61 278.84 579.07 292.76 0.126
Biofield Treated 169.07 327.93 575.92 350.51 0.025
Percent change* (%) 434.85 17.61 -0.54 19.72 -80.56

d10, d50, and d90: particle diameter corresponding to 10%, 50%, and 90% of the cumulative distribution, D(4,3): the average mass-volume diameter, and SSA: the specific surface area. *denotes the percentage change in the Particle size distribution of the Biofield Energy Treated sample with respect to the control sample.


Figure 2: Particle size distribution curve of the control and Biofield Energy Treated chromium trioxide.


Differential Scanning Calorimetry (DSC) analysis: The thermal analysis of chromium trioxide has been performed to characterize the thermal behavior of both control and Biofield Energy Treated sample (Figure 3). The DSC thermograms of the control and the treated CrO3 showed the sharp endothermic peak at 199.55°C and 200.61°C, respectively (Table 3). The melting point of the Biofield Energy Treated CrO3 was slightly increased by 0.53% compared with the control sample (Table 3).


Figure 3: DSC thermograms of the control and Biofield Energy Treated chromium trioxide.


Table 3: DSC data for both control and Biofield Energy Treated samples of chromium trioxide.

Sample Melting point (°C) ΔH(J/g)
Control Sample 199.55 89.58
Biofield Energy Treated 200.61 119.3
% Change* 0.53 33.18

ΔH: Latent heat of fusion,*denotes the percentage change of the Biofield Energy Treated chromium trioxide with respect to the control sample.


  The latent heat of fusion (ΔHfusion) the Biofield Energy Treated chromium trioxide (119.3 J/g) was significantly increased by 33.18% compared with the control sample (89.58 J/g) (Table 3). The change in the latent heat of fusion can be accredited to the disrupted molecular chains and the crystal structure[43]. Therefore, it can be presumed that Alice’s Biofield Energy Treatment (the Trivedi Effect®) may be responsible for the disruption the molecular chains and crystal structure of CrO3 which would improve the thermal stability of the treated sample compared with the control sample.


Conclusion

  The Trivedi Effect® -Consciousness Energy Healing Treatment have a significant impact on the crystallite size, particle size, surface area, and thermal properties of chromium trioxide. The PXRD peak intensities of the Consciousness Energy Healing Treated chromium trioxide were significantly altered ranging from -63.06% to 357.95% compared with the control sample. Similarly, the crystallite sizes of the Consciousness Energy Healing Treated sample were significantly altered ranging from -41.82% to 420% compared to the control sample. Overall, the average crystallite size of the Consciousness Energy Healing Treated chromium trioxide was significantly increased by 70.46% compared with the control sample. The particle size values of the Consciousness Energy Healing Treated chromium trioxide were significantly increased at d10,d50, and D(4,3) by 434.85%, 17.61%, and 19.72%, respectively and slightly decreased at d90 by 0.54% compared to the control sample. Hence, the specific surface area of the Consciousness Energy Healing Treated chromium trioxide was significantly decreased by 80.56% compared with the control sample. The ΔHfusion of the Consciousness Energy Healing Treated chromium trioxide was significantly increased by 33.18% compared with the control sample. The experimental results indicated that the Trivedi Effect® -Consciousness Energy Healing Treatment might generate a new polymorphic form of chromium trioxide which would be better powder flowability and lower solubility, hence lower the absorption, bioavailability and toxicity of chromium trioxide on inhalation, ingestion, contact to skin and eye, chronic exposure, and aggravation of pre-existing conditions. Besides, the Biofield Energy Treated chromium trioxide would be very useful in the manufacturing industry using it as a raw material.


Acknowledgements

The authors are grateful to Central Leather Research Institute, SIPRA Lab. Ltd., Trivedi Science, Trivedi Global, Inc., Trivedi Testimonials, and Trivedi Master Wellness for their assistance and support during this work.


References

  1. 1. Trott, A.T. Instruments, Suture Materials, and Closure Choices. (2012) Wounds and Lacerations (Fourth Edition 82-94.

    Pubmed|| Crossref|| Others

  2. 2. Shirini, F., Zolfigol, M. A., Torabi, S. Chromium trioxide supported on NaHSO4.H2O: Simple oxidation of alcohols in solution and solvent free conditions. (2005) Lett Org Chem 2(6): 544-546.

    Pubmed|| Crossref|| Others

  3. 3. Anger, G., Halstenberg, J., Hochgeschwender, K., et al. Chromium Compounds. (2000) Ullmann’s Encyclopedia of Industrial Chemistry.

    Pubmed|| Crossref|| Others

  4. 4. MacInnis, D. Synthetic Gem and Allied Crystal Manufacture. (1973) Park Ridge NJ: Noyes Data Corporation.

    Pubmed|| Crossref|| Others

  5. 5. Chromium Trioxide (MSDS).

    Pubmed|| Crossref|| Others

  6. 6. Trivedi, M.K., Branton, A., Trivedi, D., et al. Evaluation of vegetative growth parameters in biofield treated bottle gourd (Lagenariasiceraria) and okra (Abelmoschus esculentus). (2015) IntJ Nutrition Food Sci4(6): 688-694.

    Pubmed|| Crossref|| Others

  7. 7. Trivedi, M.K., Patil, S., Tallapragada, R.M. Effect of biofield treatment on the physical and thermal characteristics of vanadium pentoxide powders. (2013) J Material Sci Eng11: 001.

    Pubmed|| Crossref|| Others

  8. 8. Trivedi, M.K., Tallapragada, R.M. A transcendental to changing metal powder characteristics. (2008) Metal Powder Report63(9): 22-28.

    Pubmed|| Crossref|| Others

  9. 9. Dabhade, V.V., Tallapragada, R.M.R., Trivedi, M.K. Effect of external energy on the atomic, crystalline, and powder characteristics of antimony and bismuth powders. (2009) Bulletin of Materials Science 32(5): 471-479.

    Pubmed|| Crossref|| Others

  10. 10. Trivedi, M.K., Mohan, T.R.R. Biofield energy signals, energy transmission and neutrinos. (2016) AmerJ Modern Phys 5(6): 172-176.

    Pubmed|| Crossref|| Others

  11. 11. Rubik, B., Muehsam, D., Hammerschlag, R., et al. Biofield science and healing: history, terminology, and concepts. (2015) Glob Adv Health Med 4: 8-14.

    Pubmed|| Crossref|| Others

  12. 12. Barnes, P.M., Bloom, B., Nahin, R.L. Complementary and alternative medicine use among adults and children: United States, 2007. (2008) Natl Health Stat Report 12: 1-23.

    Pubmed|| Crossref|| Others

  13. 13. Koithan, M. Introducing complementary and alternative therapies. (2009) J Nurse Pract 5(1): 18-20.

    Pubmed|| Crossref|| Others

  14. 14. Trivedi, M.K., Branton, A., Trivedi, D., et al. Evaluation of plant growth, yield and yield attributes of biofield energy treated Mustard (Brassica juncea) and Chick pea (Cicer Arietinum) Seeds.(2015) Agriculture, Forestry Fisheries 4: 291-295.

    Pubmed|| Crossref|| Others

  15. 15. Trivedi, M.K., Branton, A., Trivedi, D., et al. Evaluation of Vegetative Growth Parameters in Biofield Treated Bottle Gourd (Lagenariasiceraria) and Okra (Abelmoschus esculentus).(2015) IntJ Nutrition Food Sci 4(6): 688-694.

    Pubmed|| Crossref|| Others

  16. 16. Nayak, G., Altekar, N. Effect of a biofield treatment on plant growth and adaptation. (2015) J Environ Health Sci 1(2): 1-9.

    Pubmed|| Crossref|| Others

  17. 17. Trivedi, M.K., Branton, A., Trivedi, D., et al. Evaluation of plant growth regulator, immunity and DNA fingerprinting of biofield energy treated mustard seeds (Brassica juncea). (2015) AgricultureForestry Fisheries 4(6): 269-274.

    Pubmed|| Crossref|| Others

  18. 18. Trivedi, M.K., Branton, A., Trivedi, D., et al. Antimicrobial sensitivity, biochemical characteristics and biotyping of Staphylococcus saprophyticus: An impact of biofield energy treatment. (2015) J Women’s Health Care 4: 271.

    Pubmed|| Crossref|| Others

  19. 19. Trivedi, M.K., Branton, A., Trivedi, D., et al. Antibiogram of multidrug-resistant isolates of Pseudomonas aeruginosa after biofield treatment. (2015) J Infect Dis Ther 3(5): 244.

    Pubmed|| Crossref|| Others

  20. 20. Trivedi, M.K., Patil, S., Shettigar, H., et al. In vitro evaluation of biofield treatment on cancer biomarkers involved in endometrial and prostate cancer cell lines. (2015) J Cancer Sci Ther 7: 253-257.

    Pubmed|| Crossref|| Others

  21. 21. Trivedi, M.K., Patil, S., Shettigar, H., et al. The potential impact of biofield treatment on human brain tumor cells: A time-lapse video microscopy. (2015) J Integr Oncol 4: 141.

    Pubmed|| Crossref|| Others

  22. 22. Trivedi, M.K., Tallapragada, R.M. Effect of superconsciousness external energy on the atomic, crystalline and powder characteristics of carbon allotrope powders. (2009) Materials Research Innovations 13: 473-480.

    Pubmed|| Crossref|| Others

  23. 23. Trivedi, M.K., Patil, S., Tallapragada, R.M. Effect of biofield treatment on the physical and thermal characteristics of Silicon, Tin and Lead powders. (2013) J Material Sci Eng 2:125.

    Pubmed|| Crossref|| Others

  24. 24. Trivedi, M.K., Branton, A., Trivedi, D., et al. Evaluation of the isotopic abundance ratio in biofield energy treated resorcinol using gas chromatography-mass spectrometry technique. (2016) Pharm Anal Acta 7: 481.

    Pubmed|| Crossref|| Others

  25. 25. Trivedi, M.K., Branton, A., Trivedi, D., et al. Determination of isotopic abundance ratio of biofield energy treated 1,4-dichlorobenzene using gas chromatography-mass spectrometry (GC-MS). (2016) Modern Chemistry 4(3): 30-37.

    Pubmed|| Crossref|| Others

  26. 26. Trivedi, M.K., Branton, A., Trivedi, D., et al. Fourier transform infrared and ultraviolet-visible spectroscopic characterization of biofield treated salicylic acid and sparfloxacin. (2015) Nat Prod Chem Res 3: 186.

    Pubmed|| Crossref|| Others

  27. 27. Trivedi, M.K., Patil, S., Shettigar, H., et al. Spectroscopic characterization of chloramphenicol and tetracycline: An impact of biofield. (2015) Pharm Anal Acta 6: 395.

    Pubmed|| Crossref|| Others

  28. 28. Branton, A., Jana, S. Effect of the biofield energy healing treatment on the pharmacokinetics of 25-hydroxyvitamin D3[25(OH)D3] in rats after a single oral dose of vitamin D3. (2017) American Journal of Pharmacology and Phytotherapy 2: 11-18.

    Pubmed|| Crossref|| Others

  29. 29. Branton, A., Jana, S. The influence of energy of consciousness healing treatment on low bioavailable resveratrol in male Sprague Dawley rats. (2017) International Journal of Clinical and Developmental Anatomy 3: 9-15.

    Pubmed|| Crossref|| Others

  30. 30. Branton, A., Jana, S. The use of novel and unique biofield energy healing treatment for the improvement of poorly bioavailable compound, berberine in male Sprague Dawley rats. (2017) Am J Clin and ExptMed 5: 138-144.

    Pubmed|| Crossref|| Others

  31. 31. Desktop X-ray Diffractometer “MiniFlex+”. (1997) The Rigaku Journal 14: 29-36.

    Pubmed|| Crossref|| Others

  32. 32. Zhang, T., Paluch, K., Scalabrino, G., et al. Molecular structure studies of (1S,2S)-2-benzyl-2,3-dihydro-2-(1Hinden-2-yl)-1H-inden-1-ol. (2015) J Mol Struct 1083: 286-299.

    Pubmed|| Crossref|| Others

  33. 33. Langford, J.I., Wilson, A.J.C. Scherrer after sixty years: A survey and some new results in the determination of crystallite size. (1978) J Appl Cryst 11: 102-113.

    Pubmed|| Crossref|| Others

  34. 34. Trivedi, M.K., Sethi, K.K., Panda, P., et al. A comprehensive physicochemical, thermal, and spectroscopic characterization of zinc (II) chloride using Xray diffraction, particle size distribution, differential scanning calorimetry, thermogravimetric analysis/differential thermogravimetric analysis, ultravioletvisible, and Fourier transforminfrared spectroscopy. (2017) Int J Pharm Invest 7: 33-40.

    Pubmed|| Crossref|| Others

  35. 35. Trivedi, M.K., Sethi, K.K., Panda, P., et al. Physicochemical, thermal and spectroscopic characterization of sodium selenate using XRD, PSD, DSC, TGA/DTG, UV-vis, and FT-IR. (2017) Marmara Pharmaceutical Journal 21/2: 311-318.

    Pubmed|| Crossref|| Others

  36. 36. Inoue, M., Hirasawa, I. The relationship between crystal morphology and XRD peak intensity on CaSO4.2H2O. (2013) J Crystal Growth 380: 169-175.

    Pubmed|| Crossref|| Others

  37. 37. Raza, K., Kumar, P., Ratan, S., et al. Polymorphism: The phenomenon affecting the performance of drugs. (2014) SOJ Pharm Pharm Sci 1: 10.

    Pubmed|| Crossref|| Others

  38. 38. Brittain, H.G. Polymorphism in pharmaceutical solids in Drugs and Pharmaceutical Sciences, volume 192, 2ndEdn. (2009) Informa Healthcare USA, Inc., New York.

    Pubmed|| Crossref|| Others

  39. 39. Censi, R., Martino, P.D. Polymorph impact on the bioavailability and stability of poorly soluble drugs. (2015) Molecules 20: 18759-18776.

    Pubmed|| Crossref|| Others

  40. 40. Blagden, N., de Matas, M., Gavan, P.T., et al. Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. (2007) Adv Drug Deliv Rev 59: 617-630.

    Pubmed|| Crossref|| Others

  41. 41. Mosharrof, M., Nystrom, C. The effect of particle size and shape on the surface specific dissolution rate of microsized practically insoluble drugs. (1995) Int J Pharm 122: 35-47.

    Pubmed|| Crossref|| Others

  42. 42. Buckton, G., Beezer,A.E. The relationship between particle size and solubility. (1992) Int J Pharmaceutics 82: R7-R10.

    Pubmed|| Crossref|| Others

  43. 43. Zhao, Z., Xie, M., Li, Y., et al. Formation of curcumin nanoparticles via solution-enhanced dispersion by supercritical CO2. (2015) Int J Nanomedicine 10:3171-3181.

    Pubmed|| Crossref|| Others