Anurag Tripathi
Research ScientistFood Toxicology Division
Indian Institute of Toxicology Research
biography
Dr Anurag Tripathi got his MS degree (2004) and later Ph.D (2008) in Biotechnology from School of Biotechnology, Banaras Hindu University, India. He started his career as an immunologist and his Ph.D work was dedicated to exploration of fundamental regulatory links between innate immunity and endocrine system, where he could show that pituitary hormones Prolactin and Somatotropin could direct the response of macrophages towards classical activation. Following his Ph.D, he moved to CSIR-Indian Institute of Toxicology Research as Scientist and made significant contributions to the area of Food, Drug and Chemical Toxicology and Nanomaterial toxicology. He has worked on a variety of projects having industrial and societal relevance including Grant-in-Aid projects and CSIR network projects focused on new paradigms in investigative toxicology, applications and impact of nanomaterials, food additives, contaminants and adulterants on public safety, human health and environment. Dr Tripathi has authored more than 30 publications in international peer reviewed journals of Immunology and Toxicology.
Area of Interest
1)Nanotoxicology
2)skin carcinogenesis
3)Innate immunity
4)T-cell
5)nano-materials
6)Food additives
7)Adulterants on the immune system.
top publication
1. Tripathi A, Sodhi A. Growth hormone-induced production of cytokines in murine peritoneal macrophages in vitro: role of JAK/STAT, PI3K, PKC and MAP kinases. Immunobiology. 2009;214(6):430-40. Epub 2009 Feb 27. PubMed PMID: 19250698.
2. Sodhi A, Tripathi A. Prolactin induced production of cytokines in macrophages involves Ca++ and p42/44 MAP kinase signaling pathway. Growth Factors. 2008 Aug;26(4):212-9. PubMed PMID: 19021033.
3. Sodhi A, Tripathi A. Prolactin and growth hormone induce differential cytokine and chemokine profile in murine peritoneal macrophages in vitro: involvement of p-38 MAP kinase, STAT3 and NF-kappaB. Cytokine. 2008 Feb;41(2):162-73. Epub 2008 Jan 8. PubMed PMID: 18248819.
4. Tripathi A, Sodhi A. Prolactin-induced production of cytokines in macrophages in vitro involves JAK/STAT and JNK MAPK pathways. Int Immunol. 2008 Mar;20(3):327-36. Epub 2008 Jan 10. PubMed PMID: 18187558.
5. Tripathi A, Sodhi A. Production of nitric oxide by murine peritoneal macrophages in vitro on treatment with prolactin and growth hormone: involvement of protein tyrosine kinases, Ca(++), and MAP kinase signal transduction pathways. Mol Immunol. 2007 May;44(12):3185-94. Epub 2007 Mar 2. PubMed PMID: 17336385.
6. Dwivedi PD, Tripathi A*, Ansari KM, Shanker R, Das M. Impact of nanoparticles on the immune system. J Biomed Nanotechnol. 2011 Feb;7(1):193-4. PubMed PMID: 21485866.
7. Roy R, Tripathi A*, Das M, Dwivedi PD. Cytotoxicity and uptake of zinc oxide nanoparticles leading to enhanced inflammatory cytokines levels in murine macrophages: comparison with bulk zinc oxide. J Biomed Nanotechnol. 2011 Feb;7(1):110-1. PubMed PMID: 21485828.
8. Das M, Ansari KM, Tripathi A, Dwivedi PD. Need for safety of nanoparticles used in food industry. J Biomed Nanotechnol. 2011 Feb;7(1):13-4. PubMed PMID: 21485778.
9. Misra A, Kumar R, Mishra V, Chaudhari BP, Tripathi A, Das M, Dwivedi PD. Partial characterization of red gram (Cajanus cajan L. Millsp) polypeptides recognized by patients exhibiting rhinitis and bronchial asthma. Food Chem Toxicol. 2010 Oct;48(10):2725-36. Epub 2010 Jul 3. PubMed PMID: 20600518.
10. Kumar S, Verma A K, Misra A, Tripathi A, Chaudhari B P, Prasad R, Jain S K, Das M, Dwivedi P D. Allergenic responses of red kidney bean (Phaseolus vulgaris cv chitra) polypeptides in BALB/c mice recognized by bronchial asthma and allergic rhinitis patients. Food Res. International. 2011 44(9):2868–2879.
11. Kumar S, Misra A, Verma A K, Roy R, Tripathi A, Ansari K M, Das M and Dwivedi P D. Bt Brinjal in India: A long way to go. GM Crops. 2011 Apr 1;2(2).
12. Yadav A, Kumar A, Dwivedi PD, Tripathi A*, Das M. In vitro studies on immunotoxic potential of Orange II in splenocytes. Toxicol Lett. 2012. 208(3):239-45.
13. Verma AK, Kumar S, Tripathi A, Chaudhari BP, Das M, Dwivedi PD. Chickpea (Cicer arietinum) proteins induce allergic responses in nasobronchial allergic patients and BALB/c mice. Toxicol Lett. 2012 Apr 5;210(1):24-33.
14. Yadav A, Kumar A, Tripathi A*, Das M. Sunset yellow FCF, a permitted food dye, alters functional responses of splenocytes at non-cytotoxic dose. Toxicol Lett. 2013 Mar 13;217(3):197-204.
15. Kumar S, Dwivedi PD, Das M, Tripathi A*. Macrophages in food allergy: An enigma. Mol Immunol. 2013 Jul 31;56(4):612-618.
16. Kumar S, Verma AK, Sharma A, Kumar D, Tripathi A, Chaudhari BP, Das M, Jain SK, Dwivedi PD. Phytohemagglutinins augment red kidney bean (Phaseolus vulgaris L.) induced allergic manifestations. J Proteomics. 2013 Nov 20;93:50-64.
. 17. Roy R, Kumar S, Verma AK, Sharma A, Chaudhari BP, Tripathi A, Das M, Dwivedi PD. Zinc oxide nanoparticles provide an adjuvant effect to ovalbumin via a Th2 response in Balb/c mice. Int Immunol. 2014 Mar;26(3):159-72. doi: 10.1093/intimm/dxt053. Epub 2013 Nov 13. PubMed PMID: 24225181.
18. Roy R, Kumar S, Tripathi A, Das M, Dwivedi PD. Interactive threats of nanoparticles to the biological system. Immunol Lett. 2014 March April;158(1-2):79-87. doi: 10.1016/j.imlet.2013.11.019. Epub 2013 Dec 4. Review. PubMed PMID: 24316409.
19. Roy R, Parashar V, Chauhan LK, Shanker R, Das M, Tripathi A*, Dwivedi PD. Mechanism of uptake of ZnO nanoparticles and inflammatory responses in macrophages require PI3K mediated MAPKs signaling. Toxicol In Vitro. 2014 Apr;28(3):457-67. doi: 10.1016/j.tiv.2013.12.004. Epub 2013 Dec 22. PubMed PMID: 24368203.
20. Tiwari SK, Agarwal S, Seth B, Yadav A, Nair S, Bhatnagar P, Karmakar M, Kumari M, Chauhan LK, Patel DK, Srivastava V, Singh D, Gupta SK, Tripathi A, Chaturvedi RK, Gupta KC. Curcumin-loaded nanoparticles potently induce adult neurogenesis and reverse cognitive deficits in Alzheimer's disease model via canonical Wnt/β-catenin pathway. ACS Nano. 2014 Jan 28;8(1):76-103. doi: 10.1021/nn405077y. Epub 2013 Dec 10. PubMed PMID: 24467380.