biography
Dr Bipasha Bose obtained her Ph.D. degree in Applied Biology (Molecular Carcinogenesis) from Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India in 2004. She has a more than 11 years of post-PhD research experience working in Stem Cell Biology, in academia and industry in India, Belgium and Singapore. Dr Bose holds key skills in the field of clinical, as well as, R and D grade stem cells. Her noted contributions to the field of regenerative medicine involve her co-work with the scientists for deriving human embryonic stem cells (hESC) for the first time from the Indian subcontinent, differentiation of hESC into functional insulin producing β islets and their pre-clinical translation, differentiation of hESC into functional hepatocytes. She has also contributed in the field of adult stem cell biology and proven the myogenic potential of aged muscle stem cells and perivascular mesenchymal stem cells, hepatocyte differentiation from Multipotent Adult Progenitor cells. Her contribution in the field of basic biology of stem cells has proven the pluripotent conversion of myostatin- null muscle stem cells without using reprogramming factors. She has contributed to several publications and book chapters as the lead author in the peer-reviewed journals and books of international repute. Dr. Bose also has two patents to her credit. Currently, Dr Bose is working in Yenepoya Research Centre, Yenepoya University. Her present focus is on establishing R and D scale human and mouse stem cell laboratories, guiding Ph.D students in her area of expertise of basic biology of stem cells and stem cell therapy for diabetes, liver diseases and muscle disorders.
Area of Interest
• Differentiation of Embryonic Stem Cells (ESC), Induced Pluripotent stem cells (iPSC) and multipotent adult progenitor cells (MAPC) from bone marrow into hepatocytes in 2D and 3D culture systems as a progress towards regenerative medicine for acute liver failure • Use of human ES and iPS cells derived hepatocytes for making bio-artifical liver devices. • Kidney differentiation from Embryonic Stem Cells, Induced Pluripotent Stem cells and MAPC. • Ecat1 transcriptional gene and it’s role in pluripotency-Basic research • Differentiation of multipotent Adult progenitor cells (MAPC) from bone marrow into pancreatic beta islet cells as a progress towards regenerative medicine for diabetes.
top publication
• Shenoy PS*, Bose B#*,. Enhancing the stemness/plasticity of dental stem cells using growth factors, small molecules and scaffolds for tissue engineering. 2015. Accepted for publication with recommended minor revisions in Jacobs Journal of Regenerative Medicine, Vol.1(1), 002
• Bose B*, Shenoy PS, Reza MM, McFarlane CD, Sharma, M and Kambadur, R. 2014. Plasticity of muscle derived stem cells to undergo pluripotent conversion without pluripotency factors or small molecules. Cytotherapy, Vol. 16, Issue 4, Supplement: S71. (Published as selected abstracts presented in 20th Annual Meeting of International Society for Cellular Therapy, Paris, April 24-26, 2014.
• Shenoy PS, Bose B, Sharmar M and Kambadur R. 2014. Myogenic propensities of cells obtained from liver by preplating. Cytotherapy, Vol. 16, Issue 4, Supplement: S71. (Published as selected abstracts presented in 20th Annual Meeting of International Society for Cellular Therapy, Paris, April 24-26, 2014.
• Bose B#**, Shenoy PS#. 2014. Stem Cell versus Cancer and cancer stem cell: intricate balance decides their respective usefulness or harmfulness in the biological system. Journal of Stem Cell Research and Therapy, Vol.4, 173: doi: 10.4172/2157-7633.1000173
• Shenoy PS*, Bose B*, Sharma M, McFarlane C, Kambadur R. 2014. Lack of Myostatin reduces MyoD gene uptake and subsequent myogenesis in primary mouse fibroblasts isolated from skeletal muscle. Accepted for publication in Journal of Cellular Biochemistry, June 6. doi 10.1002/jcb.24860.
• Bose B#**, Shenoy PS**#. Non Insulin producing cell line, MIA PaCa-2 is rendered insulin producing in vitro via mesenchymal epithelial transition. Journal of Cellular Biochemistry, 2013, Volume 114 (7):1642-52 doi:10.1002/jcb.24506 (Online May 09, 2013).• Bose B**, Shenoy PS, Konda S and Wangikar P. Human embryonic stem cell differentiation into insulin secreting beta cells for diabetes, Cell Biology International 2012, Oct 02 Online, Volume 36 (11): 1013–1020