Das Joydip

Associate Professor


Joydip Das is an Associate Professor at the Department of Pharmacological and Pharmaceutical Sciences, University of Houston. He received his B.Sc. (Honors) in chemistry from the Presidency College, Kolkata and M.Sc. in organic chemistry from the Burdwan University, West Bengal. He received his Ph.D. from the Indian Institute of Technology, Bombay in bioorganic chemistry. He got his post-doctoral training at the Medical University of South Carolina, Massachusetts Institute of Technology and Massachusetts General Hospital. His currents research goals are to characterize the presynaptic targets of alcohol in the brain and develop alcohol antagonists. His research projects are funded by National Institutes of Health.


Area of Interest

To characterize the presynaptic targets of alcohol in the brain and develop alcohol antagonists.

top publication

1. S. Pany and J. Das, Alcohol binding in the C1 (C1A+C1B) domain of protein kinase C epsilon, Biochim. Biophys. Acta, 2015 (in press).(Impact factor 3.8).
2. G. Rahman and J. Das, Modeling studies on the structural determinants for the DAG/phorbol ester binding to C1 domain, J. Biomol. Struct. Dyn.,33, 219-32 (2015).(Impact factor 2.9)
3. J. Das and Ghazi M. Rahman, C1 domains: structure and ligand-binding properties, Chem. Rev.114, 12108-31(2014). (Impact factor 45.6)
4. J. Das, S, Xu, S. Pany, A. Guillory and G.W. Roman, The Presynaptic Munc13-1 binds alcohol and modulates alcohol self-administration in Drosophila, J. Neurochem.126, 715-26 (2013).(Impact factor 4.01)
5. J. Das, Protein Kinase C: the drug target one must see, Med. Chem. 2, e103. Doi: 10.4172/2161-0444.1000e103.
6. G. M. Rahman, S. Shanker, N. E. Lewin, B. V. V. Prasad, P. M. Blumberg and J. Das, Identification of the Activator Binding Residues in the Second Cysteine-Rich Regulatory Domain of Protein Kinase C Theta (PKCθ), Biochem. J.451, 33-44 (2013).(Impact factor 4.89)
7. S. Pany, A. Majhi and J. Das, PKC activation by resveratrol analog with unsaturated aliphatic chain, PLOS ONE, 2012;7(12):e52888. doi: 10.1371/journal.pone.0052888(Impact factor 4.0).
8. S. Shanmugasundararaj*, J. Das*, W. S. Sandberg, X. Zhou, D. Wang, R. O. Messing, K.S. Bruzik, T. Stehle and K. W. Miller, Structural and functional characterization of an anesthetic binding site in the second cysteine rich domain of protein kinase C delta, Biophys. J., 103, 2331-2338 (2012). *, joint 1st authors (Impact factor 4.2)
9. J. Das, S. Pany, S. Panchal, A. Majhi and G.M. Rahman, Binding of isoxazole and pyrazole derivatives of curcumin with the activator binding domain of novel protein kinase C, Bioorg. Med. Chem. 19, 6196-202 (2011). (Impact factor 3.15, citation2)
10. S.C. Gupta, R. Kannapan, J. Hye Kim, G. M. Rahman, S.K. Francis, R. Raveendran, M.S. Nair, J. Das and B.B. Aggarwal, Bharangin, a DiterpenoidQuinonemethide, Abolishes Constitutive and Inducible NF-kB Activation by Modifying p65 on Cysteine 38 residue and Inhibiting IkBalpha Kinase Activation, Leading to Suppression of NF-kB-Regulated Gene expression and Sensitization of Tumor Cells to Chemotherapeutic Agents., Mol. Pharmacol. 80, 769-81 (2011). (Impact factor4.8, citation 1)
11. J. Das, S. Pany and A. Majhi, Chemical modifications of resveratrol for improved protein kinase C alpha activity, Bioorg. Med.Chem. 19, 5321-5333 (2011).(Impact factor 3.15, citation3)
12. J. Das, Aliphatic diazirines as probes for proteins: recent developments, Chem. Rev.111, 4405-17 (2011).(Impact factor 40.19, citation8)
13. R. Howard, P. Slesinger, D. Davies, J. Das, R. Harris and J. Trudell, The alcohol binding site: quest for atomic level resolution, Alcohol. Clin.Ex. Res. 35, 1561-1573 (2011).(Impact factor 3.34, citation4)
14. A. Majhi, G.M. Rahman, S. Panchal and J. Das, Binding of curcumin and its long chain derivatives to the activator binding domain of novel Protein Kinase C., Bioorg. Med. Chem. 18, 1591-1598 (2010).(Impact factor 3.15, citation13)
15. J. Das, S. Pany, G. M. Rahman and S. J. Slater, PKC epsilon has an alcohol binding site in its second cysteine rich regulatory domain.,Biochem. J., 421, 405-413 (2009).(Impact factor 4.89, citation13)