biography
Dr. Jack Ho Wong, Ph.D., is Research Associate at the Faculty of Medicine, Chinese University of Hong Kong, China. He received his PhD degree and postdoctoral training from the same university. He has published over 90 peer-reviewed papers on antifungal proteins and peptides of diverse origins
Area of Interest
1)cathelicidins, lactoferrin-derived peptides
2)Defensins and thaumatin-like proteins
3)Hemagglutinins/lectins
4)Ribosome inactivating proteins.
top publication
1: Ng TB, Cheung RC, Wong JH, Wang Y, Ip DT, Wan DC, Xia J. Antiviral activities of whey proteins. Appl Microbiol Biotechnol. 2015 Jul 22. [Epub ahead of print] PubMed PMID: 26198883.
2: Cheung RC, Ng TB, Wong JH. Marine Peptides: Bioactivities and Applications. Mar Drugs. 2015 Jun 29;13(7):4006-43. doi: 10.3390/md13074006. Review. PubMed PMID: 26132844; PubMed Central PMCID: PMC4515606.
3: Yin C, Wong JH, Ng TB. Isolation of a Hemagglutinin with Potent Antiproliferative Activity and a Large Antifungal Defensin from Phaseolus vulgaris cv. Hokkaido Large Pinto Beans. J Agric Food Chem. 2015 Jun 10;63(22):5439-48. doi: 10.1021/acs.jafc.5b00475. Epub 2015 May 28. PubMed PMID: 25965006.
4: Ng TB, Fai Cheung RC, Wing Ng CC, Fang EF, Wong JH. A review of fish lectins. Curr Protein Pept Sci. 2015;16(4):337-51. PubMed PMID: 25929869.
5: Ng TB, Cheung RC, Wong JH, Bekhit AA, Bekhit Ael-D. Antibacterial products of marine organisms. Appl Microbiol Biotechnol. 2015 May;99(10):4145-73. doi: 10.1007/s00253-015-6553-x. Epub 2015 Apr 15. PubMed PMID: 25874533.
6: Dan X, Wong JH, Fang EF, Chan FC, Ng TB. Purification and Characterization of a Novel Hemagglutinin with Inhibitory Activity toward Osteocarcinoma Cells from Northeast China Black Beans. J Agric Food Chem. 2015 Apr 22;63(15):3903-14. doi: 10.1021/acs.jafc.5b00106. Epub 2015 Apr 9. PubMed PMID: 25816710.
7: Cheung RC, Wong JH, Pan W, Chan YS, Yin C, Dan X, Ng TB. Marine lectins and their medicinal applications. Appl Microbiol Biotechnol. 2015 May;99(9):3755-73. doi: 10.1007/s00253-015-6518-0. Epub 2015 Mar 21. PubMed PMID: 25794876.
8: Li N, Zhao L, Ng TB, Wong JH, Yan Y, Shi Z, Liu F. Separation and purification of the antioxidant compound hispidin from mushrooms by molecularly imprinted polymer. Appl Microbiol Biotechnol. 2015 Mar 20. [Epub ahead of print] PubMed PMID: 25786737.
9: Man GC, Wang WW, Yim AP, Wong JH, Ng TB, Lam TP, Lee SK, Ng BK, Wang CC, Qiu Y, Cheng JC. Correction: wai, m.g.C., et Al. A review of pinealectomy-induced melatonin-deficient animal models for the study of etiopathogenesis of adolescent idiopathic scoliosis. Int. J. Mol. Sci. 2014, 15, 16484-16499.
10: Wong JH, Liu Z, Law KW, Liu F, Xia L, Wan DC, Ng TB. A study of effects of peptide fragments of bovine and human lactoferrins on activities of three key HIV-1 enzymes. Peptides. 2014 Dec;62:183-8. PubMed PMID: 25445609. 11: Yin C, Wong JH, Ng TB. Recent studies on the antimicrobial peptides lactoferricin and lactoferrampin. Curr Mol Med. 2014;14(9):1139-54. Review. PubMed PMID: 25324002.
12: Feldinger K, Generali D, Kramer-Marek G, Gijsen M, Ng TB, Wong JH, Strina C,Cappelletti M, Andreis D, Li JL, Bridges E, Turley H, Leek R, Roxanis I, Capala J, Murphy G, Harris AL, Kong A. ADAM10 mediates trastuzumab resistance and is correlated with survival in HER2 positive breast cancer. Oncotarget. 2014 Aug 30;5(16):6633-46.
13: Lau KM, Wong JH, Wu YO, Cheng L, Wong CW, To MH, Lau CP, Yew DT, Leung PC,Fung KP, Hui M, Ng TB, Lau CB. Anti-dermatophytic activity of bakuchiol: in vitro mechanistic studies and in vivo tinea pedis-inhibiting activity in a guinea pig model. Phytomedicine. 2014 Jun 15;21(7):942-5
. 14: Pan WL, Wong JH, Fang EF, Chan YS, Ng TB, Cheung RC. Preferential cytotoxicity of the type I ribosome inactivating protein alpha-momorcharin on human nasopharyngeal carcinoma cells under normoxia and hypoxia. Biochem Pharmacol. 2014 Jun 1;89(3):329-39.
15: Wang CR, Zhou R, Ng TB, Wong JH, Qiao WT, Liu F. First report on isolation of methyl gallate with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibitory activities from a mushroom (Pholiota adiposa). Environ Toxicol Pharmacol. 2014 Mar;37(2):626-37. 16: Cheung RC, Wong JH, Pan WL, Chan YS, Yin CM, Dan XL, Wang HX, Fang EF, Lam SK,Ngai PH, Xia LX, Liu F, Ye XY, Zhang GQ, Liu QH, Sha O, Lin P, Ki C, Bekhit AA,Bekhit Ael-D, Wan DC, Ye XJ, Xia J, Ng TB. Antifungal and antiviral products of marine organisms. Appl Microbiol Biotechnol. 2014 Apr;98(8):3475-94.
17: Yin CM, Wong JH, Xia J, Ng TB. Studies on anticancer activities of lactoferrin and lactoferricin. Curr Protein Pept Sci. 2013 Sep;14(6):492-503. PubMed PMID: 23968351.
18: Wong JH, Ye XJ, Ng TB. Cathelicidins: peptides with antimicrobial, immunomodulatory, anti-inflammatory, angiogenic, anticancer and procancer activities. Curr Protein Pept Sci. 2013 Sep;14(6):504-14. PubMed PMID: 23968350.
19: Ng TB, Cheung RC, Wong JH, Ye XJ. Antimicrobial activity of defensins and defensin-like peptides with special emphasis on those from fungi and invertebrate animals. Curr Protein Pept Sci. 2013 Sep;14(6):515-31. PubMed PMID: 23968349.
20: Lin P, Wong JH, Ng TB, Ho VS, Xia L. A sorghum xylanase inhibitor-like protein with highly potent antifungal, antitumor and HIV-1 reverse transcriptase inhibitory activities. Food Chem. 2013 Dec 1;141(3):2916-22.