Marek W. Radomski




Area of Interest

Dr. Marek W. Radomski interested in mediator pharmacology including nitric oxide and matrix metalloproteinases, platelet biology, nanopharmacology and nanomedicine.

top publication

1. Swies, J., Radomski, M. and Gryglewski, R.J. Angiotensin-induced release of prostacyclin (PGI2) into circulation of anaesthetized cats. Pharmacol. Res.Commun.11:649-655(1979).
2. Nowak, J., Radomski, M., Kaijser, L., and Gryglewski, R.J. Conversion of exogenous arachidonic acid to prostaglandins in the pulmonary circulation in vivo. A human and animal study. Acta Physiol.Scand.112:405-411(1981).
3. Swies, J., Radomski, M., and Gryglewski, R.J. On the mechanism of angiotensin II release of prostacyclin. Pharmacol. Res.Commun.13:37-40(1981).
4. Radomski, M., Swies, J., and Gryglewski, R.J. Disaggregatory action of phosphodiesterase inhibitors. Pharmacol. Res. Commun. 13:41-47(1981).
5. Vargas, R.J., Radomski, M., and Moncada, S. The use of prostacyclin in the separation from plasma and washing of human platelets. Prostaglandins 23:929-945(1982).
6. Blackwell, G.J., Radomski, M., Vargas, J.R., and Moncada, S. Prostacyclin prolongs viability of human washed platelets. Biochem.Biophys.Acta 718:60-65(1982).
7. Radomski, M., and Moncada, S. An improved method for washing of human platelets with prostacyclin. Thromb. Res.30:383-389(1983).
8. Read, N.G., Radomski, M.W., Goodwin, D.A., and Moncada, S. An ultrastructural study of human washed platelets after washing with prostacyclin. Br. J. Haematol.60:305-314(1985).
9. Swies, J., Radomski, M., Dembinska-Kiec, A., Korbut, R., Gryglewski, R.J., Brandt, R., Nowak, J. Stimulatory cholinergic effect on the release of antiaggregatory activity into the circulation of cat and man and its modification by beta-adrenergic antagonists. Eur.J.Clin.Invest. 15:320-326(1985).
10. Blackwell, G.J., Radomski, M., and Moncada, S. Inhibition of human platelet aggregation by vitamin K. Thromb. Res.37:103-114(1985).
11. Radomski, M., Michalska, Z., Marcinkiewicz, E., and Gryglewski, R.J. Salicylates and 12- lipoxygenase activity in human washed platelets. Pharmacol. Res. Commun.18:1015-1030(1986).
12. Radomski, M.W., Palmer, R.M.J., and Moncada, S. Comparative pharmacology of endothelium- derived relaxing factor, nitric oxide and prostacyclin in platelets. Br. J. Pharmacol.92:181-187(1987).
13. Radomski, M.W., Palmer, R.M.J., and Moncada, S. The antiaggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide. Br. J. Pharmacol.92:639-647(1987).
14. Radomski, M.W., Palmer, R.M.J., and Moncada, S. Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. The Lancet ii:1957-1058(1987).
15. Radomski, M.W., Palmer, R.M.J., and Moncada, S. The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochem. Biophys. Res. Commun.148:1482-1489(1987).
16. Radomski, M.W., Palmer, R.M.J., Read, N.G., and Moncada, S. Isolation and washing of human platelets with nitric oxide. Thromb. Res.50:537-546(1988).
17. Nizankowska, E., Michalska, Z., Wandzilak, M., Radomski, M., Marcinkiewicz, E., Gryglewski, R.J., and Szczeklik, A. An abnormality of arachidonic acid metabolism is not a generalized phenomenon in patients with aspirin - induced asthma. Eicosanoids 1:45-48(1988).
18. Gryglewski, R.J., Marcinkiewicz, E., Radomski, M., and Swies, J. Prostacyclin and the mechanism of action of defibrotide. Eicosanoids 2:163-167(1989).
19. Radomski, M.W., Herbaczynska-Cedro, K., and Ceremuzynski, L. Increased activity of human polymorphonuclear leukocytes in acute myocardial infarction. Int. J. Cardiol. 27:392-393(1990).
20. Radomski, M.W., Palmer, R.M.J., and Moncada, S. An L-arginine/nitric oxide pathway present in human regulates aggregation. Proc. Natl. Acad. Sci. USA, 87:5193-5197(1990).
21. Radomski, M.W., Palmer, R.M.J., and Moncada, S. Characterization of the L-arginine: nitric oxide pathway in human platelets. Br. J. Pharmacol. 101:325-328(1990).
22. Radomski, M.W., Palmer, R.M.J., and Moncada, S. Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc. Natl. Acad. Sci. USA 87:10043-10047(1990).This paper has been featured in the Hot Papers section of The Scientist June 22, 1992.
23. Di Rosa, M., Radomski, M.W., Carnuccio, R., and Moncada, S. Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages. Biochem. Biophys. Res. Commun. 172:1246-1252(1990).
24. Radomski, M.W., Martin, J.F., and Moncada S. Synthesis of nitric oxide by the hemocytes of the American horseshoe crab (Limulus polyphemus). Phil. Trans. Royal. Soc. Lond. B 334:129-133(1991).
25. Radomski, M.W., Jenkins, D.C., Holmes, L., and Moncada, S. Human colorectal adenocarcionoma cells: Differential nitric oxide synthesis determines their ability to aggregate platelets. Cancer Res.51: 6073-6078(1991).