biography
Austin J. Cooney, is an Associate Professor Department of Pediatrics ,University of Texas at Austin Dell Medical School . In 1994 he was awarded as Travel Award: from Keystone Symposium on Steroid/Thyroid/Retinoic Acid Supergene Family , He was awarded by National Institutes of Health First Award NIH-NICHD in1995. During 2000 The Marc Dresden Award for Excellence in Graduate Education, BCM Graduate School of Biomedical Education, BCM honoured him . In 2007 he was honoured with Donald J. Nash Memorial Award, AAAS-SWARM . During 2008 he was awarded by Fulbright &Jaworski L. L. P. Faculty Excellence Award for Teaching and Evaluation, BCM .
Area of Interest
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1. Liu, L, Liu, L, Leung, E, Cooney, AJ,Chen, C, Rosengart, T, Dick, JE, Ma, Y, Jianchang Yang, J. Knockdown of SALL4 enhances all-trans retinoic acid-induced cellular differentiation in acute myeloid leukemia cells. J Biol Chem. 2015 Mar 3. pii: jbc.M114.634790. (2015). [Epub ahead of print] PMID: 25737450.
2. Liu S, Bou G, Sun R, Guo S, Xue B, Wei R, Cooney AJ, Liu Z. SOX2 is the faithful marker for pluripotency in pig: Evidence from embryonic studies.DevDyn. 2015 244:619-277. doi: 10.1002/dvdy.24248. PMID: 25619399.
3. Sabour, D., Xu, X., Chung, A.C., Le Menuet D., Ko K., Tapia N., Araúzo-Bravo, M.J., Gentile, L., Greber, B., Hübner, K., Sebastiano, V., Wu, G., Schöler H.R. and Cooney A.J. Germ cell nuclear factor regulates gametogenesis in developing gonads.PLoS One. 2014 Aug 20;9(8):e103985. doi: 10.1371/journal.pone.0103985. eCollection 2014. PMID: 25140725.
4. Megumi Mathison, Vivek P. Singh, Robert P. Gersch, Maricela O. Ramirez, Austin Cooney, Stephen M Kaminsky, Maria Chiuchiolo,Ahmed Nasser,Jianchang Yang, Ronald G. Crystal, and Todd K. Rosengart,. Cardiac Cellular Reprogramming with \"Triplet\" Polycistronic Vectors Encoding Gata 4, Mef2c and Tbx5 Enhances Post-Infarct Ventricular Functional Improvement Compared to Singlet Vectors. J. ThoracCardiovasc. Surg. 569: 27-32 (2014). PMID 24755332.
5. Wang, H., Wang, X., Archer, T.K., Zwaka, T.P. and Cooney A.J. GCNF-Dependent Activation of Cyclin D1 Expression Via Repression of Mir302a During ES Cell Differentiation. Stem Cells 32: 1527-37, 2014. PMID 24578347.
6. Deepavali Chakravarti1,4,* , Xiaohua Su1,*, Min Soon Cho1,4, Cristian Coarfa5,6, Avinashnarayan Venkatanarayan1,4,Ashley L. Benham6, Ramón Flores Gonzalez1,4, Jennifer Alana1, Weimin Xiao6, Marco L. Leung2,3,4, Harina Vin2,3,4, Io Long Chan1, Arianexys Aquino1,4, Nicole Müller1,4, Austin J. Cooney7, Jan Parker-Thornburg1, Kenneth Y. Tsai2,3,4, Preethi H. Gunarante6, & Elsa R. Flores1,4,8Induced multipotency in adult keratinocytes through down regulation of ΔNp63 or DGCR8. PNAS 111: 572-81, 2014. PMID 244449888.
7. Akdemir KC, Jain AK, Allton K, Aronow B, Xu X, Cooney AJ, Li W, Barton MC. Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells.Nucleic Acids Res. 42: 205-23, 2014. PMID: 24078252.
8. Seabrook JL, Cantlon, JD, Cooney AJ, McWhorter, EE, Fromme BA, Bouma GJ, Anthony, RV and Winger QA. Role of LIN28A in mouse and human trophoblast differentiation. Biol. Repro. 89: 95, 1-13 2013. PMID: 24006280.
9. Tennakoon JB*, Wang H*, Coarfa C*, Milosavljevic A, Cooney AJ# and Gunaratne PH#.Chromatin changes in Dicer-deficient mouse embryonic stem cells in response to retinoic acid induced differentiation. *contributed equally; # co-corresponding authors.PLoS One. 2013 Sep 9;8(9):e74556. doi: 10.1371/journal.pone. 0074556. PMID: 24040281.
10. Mahendram S, Kelly KF, Paez-Parent S, Mahmood S, Polena E, Cooney AJ, DobleBW.Ectopic γ-catenin expression partially mimics the effects of stabilized β-catenin on embryonic stem cell differentiation.PLoS One. 2013 May 27;8(5):e65320. doi: 10.1371/journal.pone.0065320. Print (2013).PMID: 23724138.
11. Wang Q, Wagner RT, Cooney AJ.Regulatable in vivo biotinylation expression system in mouse embryonic stem cells.PLoS One. 2013 May 7;8(5):e63532. doi: 10.1371/journal.pone.0063532. Print (2013).PMID: 23667633.
12. Wang H, Wang X, Xu X, Zwaka TP, Cooney AJ.Epigenetic Re-programming of the Germ Cell Nuclear Factor Gene is Required for Proper Differentiation of Induced Pluripotent Cells.Stem Cells 31(12) 2659-66 (2013). PMID 23495137.
13. Li, Y., Yu, W., Cooney, A.J., Schwartz, R.J. and Liu, Y. Oct4 and Canonical Wnt signaling regulate the cardiac lineage factor Mesp1 through a Tcf/Lef-Oct4 composite element. Stem Cells 31(6) 1213-7 (2013). PMID 23417899.
14. Ochsner, SA, Watkins, CM, McOwiti, A, Xu, X, Darlington, Y, DeHart, MD, Cooney, AJ, Steffen, DL, Becnel, LB and Neil J McKenna, NJ. Transcriptomine, a web resource for nuclear receptor signaling transcriptomes. Physiol. Genomics 44:853-63 (2012). PMID 22786849.
15. Becerra-Garcia R, Ordaz-Rosado D, Noé G, Chávez B, Cooney AJ,Larrea F. Comparison of 7α-methyl-19-nortestosterone effectiveness alone or combined with progestins on androgen receptor mediated transactivation.Reproduction 143:211-9 (2012) PMID: 22065861.
16. Luo, Z, Xu, X, Gu, P, Lonard, D, Gunaratne, P, Cooney, AJ, Azencott, R. miRNA Regulatory Circuits in ES Cell Differentiation: A Chemical Kinetics Modeling Approach. PLoS One. 6: 1-10 e23263 (2011). PMID 22039400.
17. Gu P, Xu X, Le Menuet D, Chung AC, Cooney AJ. Differential Recruitment of MBDs and Dnmts by the Orphan Receptor GCNF Initiates the Repression and Silencing of Oct4.Stem Cells. 29:1041-51, 2011. PMID: 2160807.
18. Deng JM, Satoh K, Chang H, Zhang Z, Stewart MD, Wang H, Cooney AJ, Behringer RR. Generation of Viable Male and Female Mice from Two Fathers.BiolReprod. 84:613-8 (2011). PMID: 21148107.
19. Wagner, R.T., Xu, X., Yi, F., Merrill, B.J. and Cooney, A.J. Canonical Wnt/b-Catenin Regulation of Liver Receptor Homolog-1 Mediates Pluripotency Gene Expression. Stem Cells 28:1794-1804, 2010.PMID: 20734354.
20. Rivera-Guevara C, Pérez-Alvarez V, García-Becerra R, Ordaz-Rosado D, Morales-Ríos MS, Hernández-Gallegos E, Cooney AJ,Bravo-Gómez ME, Larrea F, Camacho J. Genomic action of permanently charged tamoxifen derivatives via estrogen receptor-alpha.Bioorg. Med. Chem. 18:5593-601 (2010). PMID: 20621492.
21. García-Becerra R, Berno V, Ordaz-Rosado D, Sharp ZD, Cooney AJ, Mancini MA, Larrea F. Ligand-induced large-scale chromatin dynamics as a biosensor for the detection of estrogen receptor subtype selective ligands. Gene. 458:37-44, 2010 Mar 24. PMID: 20347019.
22. Adhikari D, Zheng W, Shen Y, Gorre N, Hämäläinen T, Cooney AJ,Huhtaniemi I, Lan ZJ, Liu K.Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles.Hum Mol Genet. 19:397-410, 2010.PMID: 19843540.
23. Uhlenhaut, N.H., Jakob, S., Anlag, K., Eisenberger, T., Sekido, R., Kress, J., Treier A.-C., Klugmann, C., Klasen, C., Holter, N.I., Riethmacher, D., Schutz, G., Cooney, A.J., Lovell-Badge, R., Trier, M. Somatic reprogramming of an adult ovary to testis by FOXL2 ablation. Cell 139: 1130-1142, 2009. PMID: 20005806
24. Akamatsu W, DeVeale B, Okano H, Cooney AJ, van der Kooy D.Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage.J Neurosci. 29(7):2113-24 (2009). PMID: 19228964.
25. Lan ZJ, Xu X, Chung AC, Cooney AJ.Extra-Germ Cell Expression of Mouse Nuclear Receptor Subfamily 6, Group A, Member 1 (NR6A1).BiolReprod. 80(5):905-12 (2009). PMID: 19164181.