1. R&D of Natural Products
2. Pathophysiology of Diabetic and Hypertensive Disorders
3. Therapeutics of X-syndrome
4. Scientific View of Chines Traditional Medicine
5. Screen of Bioactivity in Animal Models

1. Lee, J.P., Chen, W., Wu, H.T., Lin, K.C. and Cheng, J.T. (2011) Metformin can activate imidazoline I-2 receptors to lower plasma glucose in type-1 like diabetic rats. Hormone & Metab. Res., 43: 26 – 30.
2. Cheng, J.T., Chen, I.H., Yu, B.C. and Tong, Y.C. (2011) Loperamide-induced rat prostate relaxation through activation of peripheral µ-opioid receptors. Neurourol. Urodyn., 30: 468 – 471.
3. Chen, Z.C., Yu, B.C., Chen, L.J., Cheng, K.C., Lin, H.J. and Cheng, J.T. (2011) Characterization of the mechanisms of the increase in PPARδ expression induced by digoxin in the heart using the H9c2 cell line. Brit. J. Pharmacol., 163: 390 – 398.
4. Fong,Y., Shen, K.H., Chen, L.J. and Cheng, J.T. (2011) Changes of CCAAT enhancer-binding proteins (CEBPs) in the lung of streptozotocin-induced diabetic rats. Hormone & Metab. Res., 43: 261 – 267.
5. Lin, R.T., Chen, C.Y., Tzeng, C.Y., Lee, Y.C., Cheng, Y.W., Chen, Y.I., Ho, W.J., Cheng, J.T., Lin, J.G. and Chang, S.L. (2011) Electroacupuncture improves glucose tolerance through cholinergic nerve and nitric oxide synthase effects in rats. Neurosci. Lett., 494: 114 – 118.
6. Ou, H.Y., Wu, H.T., Yang, Y.C., Wu, J.S., Cheng, J.T. and Chang, C.J. (2011) .Elevated retinol binding protein 4 contributes to insulin resistance in spontaneously hypertensive rats. Hormone & Metab. Res., 43: 312 – 318.
7. Shieh, J.P., Cheng, K.C., Chung, H.H., Kerh, Y.F., Yeh, C.H. and Cheng, J.T. (2011) Plasma glucose lowering mechanisms of Catalpol, an active principle from roots of Rehmannia glutinosa , in streptozotocin-induced diabetic rats. J. Agricul. Food Chem., 59:3747 -3753.
8. Chen, Z.C., Shieh, J.P., Chung, H.H., Hung, C.H., Lin, H.J. and Cheng, J.T. (2011) Activation of peripheral opioid µ-receptors in blood vessel may lower blood pressure in spontaneously hypertensive rats. Pharmacol., 87: 257 – 264.
9. Niu, C.S., Wu, H.T., Cheng, K.C., Lin, K.C., Chen, C.T. and Cheng, J.T. (2011) .A novel mechanism for decreasing plasma lipid level from imidazoline I-1 receptor activation in high fat diet-fed mice. Hormone & Metab. Res.,43: 458 – 463.
10. Chiu,,Y.J., Chung, H.H., Yeh, C.H., Cheng, J.T. and Lo, S.H. (2011) Improvement of insulin resistance by Chlorella in fructose-rich chow-fed rats. Phytotherapy Res., 25: 1306 – 1312.
11. Lee, J.P., Cheng, K.C., Chung, H.H., Wu, H.T., Chen, C.T. and Cheng, J.T. (2011) Inhibition of insulin degrading enzyme by racecadotril in the brain of Wistar rats. Hormone & Metab. Res., 43: 489 – 493.
12. Liu, C.L., Wu, H.T., Hsiao, Y.H., Lai, C.W., Shih, C.W., Peng, Y.K., Tang, K.C., Chang, H.W., Chien, Y.C., Hsiao, J.K., Cheng, J.T. and Chou, P.T. (2011) Insulin-directed synthesis of fluorescent gold nanoclusters: Preservation of insulin bioactivity and versatility in cell imaging. Angew. Chem. Int Ed. Engl. 50:7056-7060.
13. Ku, P.M., Chen, L.J., Liang, J.R., Cheng, K.C., Li, Y.X. and Cheng, J.T. (2011) Molecular role of GATA binding protein 4 (GATA-4) in hyperglycemia-induced reduction of cardiac contractility. Cardiovasc. Diabetol., 10:57. doi:10.1186/1475-2840-10-57
14. Niu, C.S., Chen, C.T., Chen, L.J., Cheng, K.C., Yeh, C.H. and Cheng, J.T. (2011) Decrease of blood lipids induced by Shan-Zha (fruit of Crataegus pinnatifida) is mainly related to an increase of PPAR in liver of mice fed high-fat diet. Hormone & Metab. Res., 43: 625 – 630.
15. Wu, H.T., Chen, C.T., Cheng, K.C., Li, Y.X., Yeh, C.H. and Cheng, J.T. (2011) Pharmacological activation of peroxisome proliferator-activated receptor δ improves insulin resistance and hepatic steatosis in high fat diet-induced diabetic mice. Hormone & Metab. Res., 43: 631 – 635.
16. Yeh, C.H., Chang, C.K., Cheng, K.C., Li, Y.X., Zhang,Y.W. and Cheng, J.T. (2011) Role of bone morphogenetic proteins-7 (BMP-7) in the renal improvement effect of DangGui (Angelica sinensis) in type 1-diabetic rats. Evid. Bas. Com. Altern. Med. (eCAM), 2011, 796723, 9 pages (doi:10.1093/ecam/nep167)
17. Chen, C.T., Chen, W., Chung, H.H., Cheng, K.C., Yeh, C.H. and Cheng, J.T. (2011) Activation of imidazoline I-2B receptor by metformin to increase glucose uptake in skeletal muscle. Hormone & Metab. Res., 43: 708 – 713.
18. Yang, P.S., Wu, H.T., Chung, H.H., Chen, C.T., Chi, C.W., Yeh, C.H. and Cheng, J.T. (2012) Rilmenidine improves hepatic steatosis through p38-dependent pathway to higher the expression of farnesoid X receptor. Naunyn-Schmiedeberg's Arch. Pharmacol., 385: 51- 56.
19. Lin, K.C., Yeh, L.R., Chen, L.J., Wen, Y.J., Cheng, K.C. and Cheng JT. (2012) Plasma glucose-lowering action of allantoin is induced by activation of imidazoline I-2 receptors in streptozotocin-induced diabetic rats. Hormone & Metab. Res., 44: 41-46.
20. Lee, L.M., Lin, C.S., Chung, H.H., Lin, K.C. and Cheng JT. (2012) Urinary bladder relaxation through activation of opioid μ-receptors induced by loperamide is increased in diabetic rats. Exp. Clin. Endocrinol. Diabetes 120: 323-328.
21. Wu, H.T., Chen, W., Cheng, K.C., Ku, P.M., Yeh, C.H. and Cheng, J.T. (2012) Oleic acid activates peroxisome proliferator-activated receptorto compensate insulin resistance in steatotic cells. J. Nutrit. Biochem., 23:1264-1270.
22. Kang, L., Chen, C.H., Cheng, Y.C., Chang, C.H., Lee, C.T., Chang, J.K,, Cheng, J.T. and Chang, F.M. (2012) Glucosamine-induced insulin resistance in ovariectomized rats is relevant to decreasing the expression of glucose transport protein subtype 4 in the skeletal muscle and in increasing the size of pancreatic islets. Menopause 19:496-502.
23. Chen, I.H., Tong, Y.C. and Cheng, J.T. (2012) Metabolic syndrome decreases tissue perfusion and induces glandular hyperplasia in the fructose-fed rat prostate. Neurourol Urodyn., 31: 600-604.
24. Chen, M.F., Yang, T.T., Yeh, L.R., Chung, H.H., Wen, Y.J., Lee, W.J. and Cheng, J.T. (2012) Activation of imidazoline I-2B receptors by allantoin to increase glucose uptake into C2C12 Cells. Hormone & Metab. Res., 44:268-272.
25. Yu, H.C., Chen, L.J., Cheng, K.C., Li, Y.X., Yeh, C.H. and Cheng, J.T. (2012) Silymarin inhibits cervical cancer cell through an increase of phosphatase and tensin homolog (PTEN). Phytotherapy Res., 26: 709-715.
26. Chen, W., Chung, H.H. and Cheng, J.T. (2012) Opiate-induced constipation is related to the activation of opioid mu2-receptors in small intestine of mice. World J. Gastroent., 18:1391-1396
27. Lee, L.M., Lu, C.C., Chung, H.H. and Cheng, J.T. (2012) Prostatic relaxation induced by loperamide is reduced in spontaneously hypertensive rats. Scientific World Journal, 2012: 941685.
28. Lin, C.C., Lin, L.T., Yen, M.H., Cheng, J.T., Yeh, C.H. and Hsing, C.H. (2012) Renal protective effect of Xiao-Chai-Hu-Tang on diabetic nephropathy of type 1-diabetic mice. Evid. Bas. Com. Altern. Med. (eCAM), 2012:984024.
29. Lee, L.M., Tsai, T.C., Chung, H.H., Tong, Y.C. and Cheng, J.T. (2012) Prostatic relaxation induced by agmatine is decreased in spontaneously hypertensive rats. BJU Int., 110: E253-E258.
30. Chung, H.H., Yang, T.T., Chen, M.F., Chou, M.T., and Cheng, J.T. (2012) Improvement of Hyperphagia by Activation of Cerebral I1-Imidazoline Receptors in Streptozotocin-induced Diabetic Mice. Hormone & Metab. Res., 44: 645-649.