Cheng-Wen Lin




Area of Interest

Viral infection
Pulmonary inflammation
anti-viral agents

top publication

1. Jou YJ, Chen CJ, Liu YC, Der Way T, Lai CH, Hua CH, Wang CY, Huang SH, Kao JY, Lin CW*. Quantitative phosphoproteomic analysis reveals γ-bisabolene inducing p53-mediated apoptosis of human oral squamous cell carcinoma via HDAC2 inhibition and ERK1/2 activation.Proteomics. 2015 Jul 21. doi: 10.1002/pmic.201400568. (Corresponding author)
2. Wang CY, Huang AC, Hour MJ, Huang SH, Kung SH, Chen CH, Chen IC, Chang YS, Lien JC, Lin CW*.Antiviral Potential of a Novel Compound CW-33 against Enterovirus A71 via Inhibition of Viral 2A Protease.Viruses. 2015 Jun 17;7(6):3155-71. (Corresponding author)
3. Chang SJ, Huang SH, Lin YJ, Tsou YY, Lin CW*. Antiviral activity of Rheum palmatum methanol extract and chrysophanol against Japanese encephalitis virus.Arch Pharm Res. 2014 Sep;37(9):1117-23. (Corresponding author)
4. Jou YJ, Hua CH, Lin CD, Lai CH, Huang SH, Tsai MH, Kao JY, Lin CW*. S100A8 as potential salivary biomarker of oral squamous cell carcinoma using nanoLC-MS/MS.ClinChimActa. 2014 Sep 25;436:121-9. (Corresponding author)
5. Lin YJ, Chen CY, Jeang KT, Liu X, Wang JH, Hung CH, Tsang H, Lin TH, Liao CC, Huang SM, Lin CW, Ho MW, Chien WK, Chen JH, Ho TJ, Tsai FJ. Ring finger protein 39 genetic variants associate with HIV-1 plasma viral loads and its replication in cell culture.Cell Biosci. 2014 Aug 5;4:40.
6. Li SW, Yang TC, Lai CC, Huang SH, Liao JM, Wan L, Lin YJ, Lin CW*. Antiviral activity of aloe-emodin against influenzaA virus via galectin-3 up-regulation.Eur J Pharmacol. 2014 Sep 5;738:125-32. (Corresponding author)
7. Liao CR, Kuo YH, Ho YL, Wang CY, Yang CS, Lin CW*, Chang YS. Studies on cytotoxic constituents from the leaves of Elaeagnus oldhamii Maxim. in non-small cell lung cancer A549 cells.Molecules. 2014 Jul 4;19(7):9515-34. (Corresponding author)
8. Yang TC, Li SW, Lai CC, Lu KZ, Chiu MT, Hsieh TH, Wan L, Lin CW*. Proteomic analysis for Type I interferon antagonism of Japanese encephalitis virus NS5 protein.Proteomics. 2013 Dec;13(23-24):3442-56. doi: 10.1002/pmic.201300001. (Corresponding author)
9. Wang CY, Huang SC, Lai ZR, Ho YL, Jou YJ, Kung SH, Zhang Y, Chang YS, Lin CW*. Eupafolin and Ethyl Acetate Fraction of Kalanchoe gracilis Stem Extract Show Potent Antiviral Activities against Enterovirus 71 and Coxsackievirus A16.Evid Based Complement Alternat Med. 2013;2013:591354. doi: 10.1155/2013/591354. (Corresponding author)
10. Lan YC, Su MC, Chen CH, Huang SH, Chen WL, Tien N, Lin CW*. Epidemiology of pandemic influenza A/H1N1 virus during 2009-2010 in Taiwan.Virus Res. 2013 Oct;177(1):46-54.. (Corresponding author)
11. Hour MJ, Huang SH, Chang CY, Lin YK, Wang CY, Chang YS, Lin CW*. Baicalein, Ethyl Acetate, and Chloroform Extracts of Scutellaria baicalensis Inhibit the Neuraminidase Activity of Pandemic 2009 H1N1 and Seasonal Influenza A Viruses.Evid Based Complement Alternat Med. 2013;2013:750803. (Corresponding author)
12. Li SW, Lin CW*. Human coronaviruses: Clinical features and phylogenetic analysis. Biomedicine (Taipei) 2013;3:43-50 (review, Corresponding author)
13. Li SW, Yang TC, Wan L, Lin YJ, Tsai FJ, Lai CC, Lin CW*. Correlation between TGF beta-1 expression and proteomic profiling induced by SARS coronavirus papain like-protease.Proteomics. 2012 Nov;12(21):3193-205. doi: 10.1002/pmic.201200225. (Corresponding author)
14. Chang SJ, Chang YC, Lu KZ, Tsou YY, Lin CW*.Antiviral Activity of Isatis indigotica Extract and Its Derived Indirubin against Japanese Encephalitis Virus.Evid Based Complement Alternat Med. 2012;2012:925830. (Corresponding author)
15. Wang CY, Huang SC, Zhang Y, Lai ZR, Kung SH, Chang YS, Lin CW*.Antiviral Ability of Kalanchoe gracilis Leaf Extract against Enterovirus 71 and Coxsackievirus A16..Evid Based Complement Alternat Med. 2012;2012:503165. (Corresponding author)
16. Lin YJ, Chang YC, Hsiao NW, Hsieh JL, Wang CY, Kung SH, Tsai FJ, Lan YC, Lin CW*. Fisetin and rutin as 3C protease inhibitors of enterovirus A71.J Virol Methods. 2012 Jun;182(1-2):93-8. (Corresponding author)
17. Bai LY, Weng JR, Lo WJ, Yeh SP, Wu CY, Wang CY, Chiu CF, Lin CW*.Inhibition of hedgehog signaling induces monocytic differentiation of HL-60 cells.Leuk Lymphoma. 2012 Jun;53(6):1196-202. (Corresponding author)
18. Chang CY, Chan HL, Lin HY, Way TD, Kao MC, Song MZ, Lin YJ, Lin CW*.Rhein induces apoptosis in human breast cancer cells.Evid Based Complement Alternat Med. 2012;2012:952504. (Corresponding author)
19. Jou YJ, Lin CD, Lai CH, Tang CH, Huang SH, Tsai MH, Chen SY, Kao JY, Lin CW*. Salivary zinc finger protein 510 peptide as a novel biomarker for detection of oral squamous cell carcinoma in early stages.ClinChimActa. 2011 Jul 15;412(15-16):1357-65(Corresponding author)
20. Chen CH, Chang CP, Wu FY, Liu CL, Peng CT, Lin CW*. Prevalence of human herpesvirus 8 DNA in peripheral blood mononuclear cells of acute and chronic leukemia patients in Taiwan.FEMS Immunol Med Microbiol. 2011 Apr;61(3):356-8. (Corresponding author)
21. Li SW, Lai CC, Ping JF, Tsai FJ, Wan L, Lin YJ, Kung SH, Lin CW*. Severe acute respiratory syndrome coronavirus papain-like protease suppressed alpha interferon-induced responses through downregulation of extracellular signal-regulated kinase 1-mediated signalling pathways.J Gen Virol. 2011 May;92(Pt 5):1127-40. (Corresponding author)
22. Lan YC, Lin TH, Tsai JD, Yang YC, Peng CT, Shih MC, Lin YJ, Lin CW*. Molecular epidemiology of the 2005 enterovirus 71 outbreak in central Taiwan.Scand J Infect Dis. 2011 May;43(5):354-9. (Corresponding author)
23. Jou YJ, Lin CD, Lai CH, Chen CH, Kao JY, Chen SY, Tsai MH, Huang SH, Lin CW*. Proteomic identification of salivary transferrin as a biomarker for early detection of oral cancer.Anal ChimActa. 2010 Nov 29;681(1-2):41-8(Corresponding author)
24. Hsiao NW, Chen JW, Yang TC, Orloff GM, Wu YY, Lai CH, Lan YC, Lin CW*. ISG15 over-expression inhibits replication of the Japanese encephalitis virus in human medulloblastoma cells. Antiviral Res. 2010 Mar;85(3):504-11. (Corresponding author)
25. Lai CH, Chang NW, Lin CF, Lin CD, Lin YJ, Wan L, Sheu JJ, Chen SY, Huang YP, Sing YT, Tao TW, Lai CK, Tsai MH, Chan HL, Jou YJ, Lin CW*. Proteomics-based identification of haptoglobin as a novel plasma biomarker in oral squamous cell carcinoma.ClinChimActa. 2010 Jul 4;411(13-14):984-91. (Corresponding author)
26. Yang TC, Lai CC, Shiu SL, Chuang PH, Tzou BC, Lin YY, Tsai FJ, Lin CW*. Japanese encephalitis virus down-regulates thioredoxin and induces ROS-mediated ASK1-ERK/p38 MAPK activation in human promonocyte cells.Microbes Infect. 2010 Aug;12(8-9):643-51. (Corresponding author)
27. Yang TC, Shiu SL, Chuang PH, Lin YJ, Wan L, Lan YC, Lin CW*.Japanese encephalitis virus NS2B-NS3 protease induces caspase 3 activation and mitochondria-mediated apoptosis in human medulloblastoma cells.Virus Res. 2009 Jul;143(1):77-85. (Corresponding author)
28. Yang TC, Chang CP, Lan YC, Liu CL, Shih MC, Wu FY, Lin CW*. Recombinant ORF66 and ORFK12 antigens for the detection of human herpesvirus 8 antibodies in HIV-positive and -negative patients.Biotechnol Lett. 2009 May;31(5):629-37. (Corresponding author)
29. Huang SH, Yang TC, Tsai MH, Tsai IS, Lu HC, Chung PH, Wan L, Lin YJ, Lai CH, Lin CW*. Gold nanoparticle-based RT-PCR and real-time quantitative RT-PCR assays for detection of Japanese encephalitis virus. Nanotechnology 2008, 19: 405101.(Corresponding author)
30. Lin CW*, Wu CF, Hsiao NW, Chang CY, Li SW, Wan L, Lin YJ, Lin WY. Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71.Int J Antimicrob Agents. 2008;32:355-9. (Corresponding author)