Serafim  Papadimitriou

Chi-Hin CHO

Research Professor

biography

Professor C.H. Cho received his PhD in Pharmacology from the University of Hong Kong (HKU) in 1978. He went through his postdoctoral training in Canada and started his first faculty position in the Yang Ming Medical College and Veterans General Hospital Taipei in 1981. He joined HKU in the Department of Pharmacology from 1984 and became Chair Professor of Pharmacology in 2000. Later, Prof. Cho joined the Chinese University of Hong Kong (CUHK) in 2007 as chairman and Professor of Pharmacology. Currently, he is the Research Professor and Associate Director of the School of Biomedical Sciences, Faculty of Medicine in CUHK. He becomes Emeritus Professor in 2016. Professionally he was President (2006-2010) and Chair of Presidential Council (2012-2015) of the Gastrointestinal Pharmacology Section of the International Union of Basic and Clinical Pharmacology and visiting and honorary professors of Peking University, Fudan University, Zhejiang University, Virginia Tech, University of Maryland, University of California and others. His current research interests focus on drug development for inflammation and cancers in the gastrointestinal (GI) tract. Professor Cho is the editorial board member and associate editor in more than 25 journals in the fields of Gastroenterology and Pharmacology.

 

Area of Interest

1. Pharmacological and toxicological role of trace elements, especially zinc in the gastrointestinal tract. 2 Pathogenesis of experimental ulcers and inflammation in the gastrointestinal tract, including those induced by ethanol, stress, nonsteroidal anti-inflammatory drugs and Helicobacter pylori. 3. The carcinogenic mechanisms of nicotine, nitrosamines and cigarette smoking on the gastrointestinal tract. 4. Drug development for gastrointestinal disorders, especially traditional Chinese Medicine and peptides.


top publication

1.Lu, L., Li, Z.J., Li, L.F., Wu, W.K.K., Shen, J., Zhang, L., Chan, R.L.Y., Yu, L., Liu, Y.W., Ren, S.X., Chan, K.M. & Cho, C.H. (2015). Vascular-targeted TNFa enhances vascular function and benefits antitumor immunotherapy in colorectal cancer. J. Controlled Release 210, 134-146.

2.Shen, J., Xiao, Z.G., Wang, M.H.,To. K.F., Che, Y.C., Li, M.S., Tong, J.H., Kang W., Zhang L., Wang , L., Lu, L., Chan, R.L.Y., Yu, J., Chan, F.K.L., Sung, J.J.Y., Cheng, A.S. & Cho, C.H. (2015). MiR-490-3p targeting SMARCD1, a member of the SWI/SNF chromatin remodeling family, was epigenetically silenced in H. pylori-induced gastric carcinogenesis. Cancer Res. 75, 754-765.

3.Ren S.X., Cheng, A.S.L., To, K.F., Tong, J. H.M., Li, M.S., Wong, C.C.M., Shen, J., Zhang, L., Chan, R.L.Y., Wang, X.J., Ng, S.S.M., Chiu, L.C.M., Marquez, V.E., Gallo, R.L., Chan, F.K.L., Yu, J., Sung, J.J.Y., Wu, W.K.K. & Cho, C.H. (2012). Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer. Cancer Res. 72, 6512-6523.

4.Li, Z.J., Wu, W.K.K., Ng, S.S.M., Yu, L., Li, H.T., Wong C.C.M., Wu, Y. C., Zhang, L., Ren S.X., Sun, X.G., Chan, K.M. & Cho, C.H. (2010). A novel peptide specifically targeting the vasculature of orthotopic colorectal cancer for imaging detection and drug delivery. Controlled Release 148, 292-302.

5.Wu, W.K.K., C.H. Cho (co-correspondence author) , Lee, C., Wu, Y.C., Yu, L., Li, Z.J., Wong, C.C.M., Li, H.T., Zhang, L., Ren, S.X., Che, C.T., Yu, J. & Sung, J.J.Y. (2010). Macroautophagy and ERK phosphorylation counteract the anti-proliferative effect of proteasome inhibitor in gastric cancer cells. Autophagy, 6, 1-11.

6.Wu, W.K.K., Wong, H.P.S., Luo, S.W., Chan, K., Huang, F.Y., Hui, M.K.C., Lam, E.K.Y., Shin, V.Y., Ye, Y.N., Yang, Y.H. & Cho, C.H. (2005). 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone from cigarette smoke stimulates colon cancer growth via ?-adrencoceptors. Cancer Res. 65, 5272-5277.

7.Liu, E.S.L., Ye, Y.N., Shin, V.Y., Yuen, S.T. Leung, S.Y., Wong, B.C.Y. & Cho, C.H. (2003). Cigarette smoke exposure increases ulcerative colitis-associated colonic adenoma formation in mice. Carcinogenesis 24, 1407-1413.

8.Ma, L, Wang, W.P., Chow, J.Y.C., Lam, S.K. & Cho, C.H. (2000). The role of polyamine in gastric mucus synthesis inhibited by cigarette smoke or its extracts. Gut 47, 170-177.

9.Guo, X., Wang, W.P., Ko, J.K.S. & Cho, C.H. (1999). Involvement of neutrophils and free radicals in the potentiating effects of passive cigarette smoking on experimental inflammatory bowel disease in rats. Gastroenterology, 117: 884-892.

10.Chow, J.Y.C., Ma, L. & Cho, C.H. (1997). The potentiating action of cigarette smoke on ethanol-induced gastric mucosal damage in rats. Gastroenterology 113, 1188-1197.