Chi-Rei Wu

Associate Professor


Chi-Rei Wu completed his Ph.D. in Graduate institute of Chinese Pharmaceutical Sciences, China Medical College, Taiwan in 1997. He is a Associate Professor, in Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resource. His publications are published in few Journals.


Area of Interest

Medicinal herbs, Behavioral Pharmacology, Neurodegeneration, Neurotransmitters, Neuroscience, Diabetes, Inflammation

top publication

1. Hui-Chun Kuo, Hung-Chi Chang, Wan-Cheng Lan, Fan-Hsuan Tsai, Jung-Chun Liao and Chi-Rei Wu*. Protective effects of Drynaria fortunei against 6-hydroxydopamine-induced oxidative damage in B35 cells via the PI3K/AKT pathway. Food & Function 2014; 5:1956-1965. (SCI)
2. Chi-Rei Wu*, Muh-Hwan Su, Hang-Ching Lin. Reversal by Cistanche tubulosa from behavioral deficits in Alzheimer’s disease-like rat model: relevance for amyloid deposition and central neurotransmitter function.BMC Complementary and Alternative Medicines 2014; 14:202. (SCI)
3. Li-Wei Lin, Yueh-Hsiung Kuo, You Cheng Hseu, Chia-Wen Tsai, Ming-Tsuen Hsieh, Shiu Ching Chen, Chi-Rei Wu*. Osthole ameliorates spatial memory deficits in rats via hippocampal α1-adrenergic and D1/D2 receptors. Evidence-Based Complementary and Alternative Medicines. 2013, Volume 2013, Article ID 273682, 10 pages.(SCI)
4. Bor-Ren Huang, Cheng-Fang Tsai, Hsiao-Yun Lin, Wen-Pei Tseng, Shiang-Suo Huang, Chi-Rei Wu, Chingju Lin, Wei-Lan Yeh, Dah-Yuu Lu. Interaction of inflammatory and anti- inflammatory responses in microglia by Staphylococcus aureus-derived lipoteichoic acid. Toxicology and Applied Pharmacology2013; 269: 43-50.(SCI) 5. Kuo-Jen Wu, Yuh-Fung Chen, Huei-Yann Tsai,Chi-Rei Wu, W. GibsonWood. Guizhi-Fuling-Wan, a traditional Chinese herbal medicine, ameliorates memory deficits and neuronal apoptosis in the streptozotocin-induced hyperglycemic rodents via the decrease of Bax/Bcl2 ratio and caspase-3 expression. Evidence-9/1/2015‐3 Based Complementary and Alternative Medicines 2012, Volume 2012,Article ID 656150, 11 pages. (SCI)
6. Yuh-Fung Chen, Chien Ching, Tian-Shung Wu, Chi-Rei Wu, Wen-Tsong Hsieh, Huei-Yann Tsai. Balanophora spicata and lupeol acetate possess antinociceptive and anti-Inflammatory activities in vivo and in vitro. Evidence-Based Complementary and Alternative Medicines 2012, Volume 2012, Article ID 371273, 10 pages.(SCI)
7. Wen-Hsin Lin, Chi-Rei Wu, Hong-Zin Lee, Yueh-Hsiung Kuo, Hung-Shin Wen, Tze-Yi Lin, Chia-Ying Lee, Shi-Ying Huang, Ching-Yuang Lin. Induced apoptosis of Th2 lymphocytes and inhibition of airway hyperrespon siveness 2 and inflammation by combined lactic acid bacteria treatment. International Immunopharmacology 2012 In press. (SCI)
8. Kuo-Jen Wu, Ming-Tsuen Hsieh, Chi-Rei Wu, W. GibsonWood, Yuh-Fung Chen. Green tea extract ameliorates learning and memory deficits in ischemic rats via its active component polyphenol epigallocatechin-3-gallate by modulation of oxidative stress and neuroinflammation. Evidence-Based Complementary and Alternative Medicines 2012, Volume 2012, Article ID 163106, 11pages.(SCI)
9. Jing-Hsien Chen, Hsin-Ping Ou, Chia-Yuan Lin, Fung-Ju Lin, Chi-Rei Wu, Shu-Wei Chang, Chia-Wen Tsai. Carnosic acid prevents 6-hydroxydopamine-induced cell death in SH-SY5Y cells via mediation of glutathione synthesis. Chemical Research in Toxicology 2012; 25(9): 1893-1901. (SCI)
10.Pei-Jane Huang, You-Cheng Hseu, Meng-Shiou Lee, K.J. Senthil Kumar, Chi-Rei Wu , Li-Sung Hsu, Jiunn-Wang Liao, I-Shiung 9/1/2015‐4 Cheng, Ya-Ting Kuo, Shi-Ying Huang, Hsin-Ling Yang*. In vitro and in vivo activity of gallic acid and Toona sinensis leaf extracts against HL-60 human premyelocytic leukemia.Food and Chemical Toxicology 2012; 50(5): 3489-97.(SCI)
11.Chung-Hsin Yeh, Ming-Tsuen Hsieh, Chi-Mei Hsueh,Chi-Rei Wu, Yi-Chun Huang, Jiunn-Wang Liao, Kuan-Chih Chow*. Therapeutic effect of Yi-Chi-Tsung-Ming-Tang on amyloid β1-40-induced Alzheimer’s disease-like phenotype via an increase of acetylcholine and decrease of Amyloid β. Evidence-Based Complementary and Alternative Medicines 2012, Volume 2012, Article ID 414536, 10 pages. (SCI)
12. You-Cheng Hseu, Chih-Wei Chou, K.J. Senthil Kumar, Ke-Ting Fu, Hui-Min Wang, Li-Sung Hsu, Yueh-Hsiung Kuo, Chi-Rei Wu, Ssu-Ching Chen, Hsin-Ling Yang*. Ellagic acid protects human keratinocyte (HaCaT) cells against UVA-induced oxidative stress and apoptosis through the upregulation of the HO-1 and Nrf-2 antioxidant genes. Food and Chemical Toxicology 2012; 50(5): 1245-55.(SCI)
13.You-Cheng Hseu, Meng-Shiou Lee, Chi-Rei Wu, Hsin-Ju Cho, Kai-Yuan Lin, Guan-Hua Lai, Sheng-Yang Wang, Yueh-Hsiung Kuo, K. J. Senthil Kumar, Hsin-Ling Yang*. The chalcone flavokawain B induces G2/M cell-cycle arrest and apoptosis in human oral carcinoma HSC-3 cells through the intracellular ROS generation and downregulation of the Akt/p38 MAPK signaling pathway. Journal of Agricultural & Food Chemistry 2012; 60(9): 2385- 97.
14.Heng-Yin Ju, Shiu-Ching Chen, Kuo-Jen Wu, Hui-Chun Kuo, You-Cheng Hseu, Hui Ching, Chi-Rei Wu*. Antioxidant phenolic 9/1/2015‐5 profile from ethyl acetate fraction of Fructus Ligustri Lucidi with protection against hydrogen peroxide-induced oxidative damage in SH-SY5Y cells. Food and Chemical Toxicology 2012; 50(3-4): 492-502.(SCI)
15.You-Cheng Hseu, Chi-Rei Wu, Hsueh-Wei Chang, K.J. Senthil Kumar, Ming-Kuem Lin, Chih-Sheng Chen, Hsin-Ju Cho, Chun-Yin Huang, Chih-Yang Huang, Hong-Zin Lee, Wen-Tsong Hsieh, Jing-Gung Chung, Hui-Min Wang, Hsin-Ling Yang*. Inhibitory effects of Physalis angulata on tumor metastasis and angiogenesis. Journal of Ethnopharmacology 2011; 135(3):762-771.(SCI)
16.Chi-Rei Wu*, Wen-Hsin Lin, You-Cheng Hseu, Jin-Cherng Lien,Yung-Ta Lin, Tzu-Ping Kuo, Hui Ching. Evaluation of the antioxidant activity of five endemic Ligustrum species leaves from Taiwan flora. Food Chemistry 2011; 127: 564-571.(SCI)
17.Chi-Rei Wu, Wen-Hsin Lin, Yung-Ta Lin, Chi-Luan Wen, Hui ChingLi-Wei Lin*. nalgesic and Anti-inflammatory Property of the Methanol Extract from Ligustrum morrisonense Leaves in Rodents. The American Journal of Chinese Medicine 2011; 39(2):335-348.( SCI)
18.Wen-Hsin Lin, Chi-Rei Wu, Tony J. Fang, Jiun-Ting Guo, Shi-Ying Huang, Meng-Shiou Lee*, Hsin-Ling Yang*. Anti-Helicobacter pylori ability of fermented milk with lactic acid bacteria. Journal of the Science of Food and Agriculture 2011;91(8):1424-1431.(SCI)
19.Wen-Hsin Lin*, Chi-Rei Wu, Tony J. Fang, Meng-Shiou Lee, Kai-Li Lin, Hsin-Chun Chen, Shi-Ying Huang, You-Cheng Hseu*. Adherent properties and macrophage activation ability of 3 9/1/2015‐6 strains of lactic acid bacteria. Journal of Food Science 2011; 6(1):M1-7.(SCI)
20.Chi-Rei Wu*, You-Cheng Hseu, Jin-Cherng Lien, Li-Wei Lin, Yung-Tan Lin, Hui Ching. Triterpenoid Contents and Anti-Inflammatory Properties of the Methanol Extracts from Ligustrum Species Leaves. Molecules 2011; 16: 1-15.(SCI)
21.Lai SC, YL Ho, SC Huang, TH Huang, ZR Lai, Chi-Rei Wu, KY Lian, YS Chang*. Antioxidant and antiproliferative activities of Desmodium triflorum (L.) DC. The American Journal of Chinese Medicine 2010; 38(2):329-342.(SCI)
22.Fan-Hsiu Tsai, Hao-Yuan Cheng, Ming-Tsuen Hsieh, Chi-Rei Wu, Ying-Chih Lin, Wen-Huang Peng*. The ameliorating effects of luteolin on beta-amyloid-induced impairment of water maze performance and passive avoidance in rats. The American Journal of Chinese Medicine 2010; 38(2):279-91.(SCI)
23.Ming-Tsuen Hsieh*, Wen-Huang Peng, Chi-Rei Wu, KY Ng, CL Cheng, HX Xu. Review on experimental research of herbal medicines with anti-amnesic activity. Planta Medica 2010; 76(3):203-217.(SCI)
24.Hao-Yuan Cheng, Ming-Tsuen Hsieh, Fan-Hsiu Tsai, Chi-Rei Wu, Chuan-Sung Chiu, Min-Min Lee, Hong-Xi Xu, Zhong-Zhen Zhao, Wen-Huang Peng*.Neuroprotective effect of luteolin on amyloid β protein (25-35)-induced toxicity in cultured rat cortical neurons. Phytotherapy Research 2010; S(1):S102-108.(SCI)