Yi Charlie Chen, professor of biology, has taught at Alderson Broaddus University since 2000. He received his B.S. and M.S. from Zhejiang University in China. He then received his second M.S. and Ph.D. from Washington State University. Dr. Chen has published over 62 different papers and book chapters in a wide range of scientific journals and books. Dr. Chen is currently working on molecular biology of cancer research. His research has focused on the inhibition of anti-cancer drugs, especially natural compounds, on cancer growth with emphasis on angiogenesis and apoptosis. Dr. Chen is also working on nanochemoprevention using nanoparticles as a novel approach for cancer control. Dr. Chen is the recipient of the Faculty of the Year Award in 2013. He was also the featured professor in the 2013 spring issue of the Neuron: West Virginia Journal of Science and Research.
His research has focused on the inhibition of anti-cancer drugs, especially natural compounds, on cancer growth with emphasis on angiogenesis and apoptosis.
1. Gao Y, Rankin GO, Tu Y, Chen YC. 2016. Inhibitory Effects of the Four Main Theaflavin Derivatives Found in Black Tea on Ovarian Cancer Cells. Anticancer Res. 36(2):643-51. PMID: 26851019.
2. Gao Y, Rankin GO, Tu Y, Chen YC. 2016. Theaflavin-3,3’-digallate decreases human ovarian carcinoma OVCAR-3 cell-induced angiogenesis via Akt and NOTCH-1 pathways, not via MAPK pathways. Int J Oncol. 48: 281-292. PMID: 26648098.
3. He Z, Chen AY, Rojanasakul Y, Rankin GO, Chen YC. 2016. Gallic acid, a phenolic compound, exerts anti-angiogenesis effects via PTEN-AKT- HIF-1α-VEGF signaling pathway in ovarian cancer cells. Oncology Reports 35: 291-297. PMID: 26530725.
4. Luanpitpong S, Li J, Manke A, Brundage K, Ellis E, McLaughlin SL, Angsutararux P, Chanthra N, Voronkova M, Chen YC, Wang L, Chanvorachote P, Pei M, Issaragrisil S, Rojanasakul Y. 2015. SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma. Oncogene [Epub ahead of print] PMID: 26387547.
5. Huang H, Chen AY, Ye X, Li, B, Rojanasakul Y, Rankin GO, Chen YC. 2015. Myricetin inhibits proliferation of cisplatin-resistant cancer cells through a p53-dependent apoptotic pathway. Int J Oncol. 47: 1494-1502. PMID: 26315556.
6. Huang H, Chen AY, Rojanasakul Y, Ye X, Rankin GO, Chen YC. 2015. Dietary compounds galangin and myricetin suppress ovarian cancer cell angiogenesis. Journal of Functional Foods 15: 464-475. PMID: 26113875.
7. Block K et al. 2015. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol. 35: S276-S304. PMID: 26590477.
8. Chen J, Chen AY, Huang H, Ye X, Rollyson WD, Perry HE, Brown KC, Rojanasakul Y, Rankin GO, Dasgupta P, Chen YC. 2015. The flavonoid nobiletin inhibits tumor growth and angiogenesis of ovarian cancers via the Akt pathway. Int J Oncol. 46: 2629-2638. PMID: 25845666.
9. Wang Z, Dabrosin C, Yin X, Fuster MM, Arreola A, Rathmell WK, Generali D, Nagaraju GP, El-Rayes B, Ribatti D, Chen YC, Honoki K, Fujii H, Georgakilas AG, Nowsheen S, Amedei A, Niccolai E, Amin A, Ashraf SS, Helferich B, Yang X, Guha G, Bhakta D, Ciriolo MR, Aquilano K, Chen S, Halicka D, Mohammed SI, Azmi A, Bilsland A, Keith N, Jensen LD. 2015. Broad targeting of angiogenesis for cancer prevention and therapy. Semin Cancer Biol. 35: S224-243. PMID: 25600295.
10. Wang X., Chen YC, Li B. 2015. Aligning 3D nanofibrous networks from self-assembled phenylalanine nanofibers. RSC Advances 5: 8022-8027. PMID: 25621167. 11. He Z, Li B, Rankin GO, Rojanasakul Y, Chen YC. 2015. Selecting bioactive phenolic compounds as potential agents to inhibit proliferation and VEGF expression in human ovarian cancer cells. Oncology Letters 9(3): 1444-1450. PMID: 25663929.
12. Li B, Gao Y, Rankin GO, Rojanasakul Y, Cutler SJ, Tu Y, Chen YC. 2015. Chaetoglobosin K induces apoptosis and G2 cell cycle arrest through p53-dependent 1 pathway in cisplatin-resistant ovarian cancer cells. Cancer Letters 356: 418-33. PMID: 25304379.
13. Chen J., Creed A, Chen AY, Huang H, Li Z, Rankin GO, Ye X, Xu G, Chen YC. 2014. Nobiletin suppresses cell viability through AKT pathways in PC-3 and DU-145 prostate cancer cells. BMC Pharmacology and Toxicology 15(1): 59. PMID: 25342300.
14. Luanpitpong S., Wang L, Stueckle TA, Tse W, Chen YC, Rojanasakul Y. 2014. Caveolin-1 regulates lung cancer stem-like cell induction and p53 inactivation in carbon nanotube-driven tumorigenesis. Oncotarget 5(11): 3541-3554. PMID: 24939878.
15. Lohcharoenkal W, Wang L, Chen YC, Rojanasakul Y. 2014. Protein Nanoparticles as Drug Delivery Carriers for Cancer Therapy. BioMed Research International 2014: 180549. PMID: 24772414.
1. Chen, AY, YC Chen. 2013. Multipotent Flavonoid Kaempferol: Molecular Targets and Mechanism of Action and Nanotechnology applications in Cancer and Human Health. P. 171-186. In G. Villers & Y. Fougere (Ed.) “Kaempferol: Chemistry, Natural Occurrences and Health Benefits”. Nova Publishers, Hauppauge NY. 2. Hu, C., and Y. Chen. 2000. Application of Entomological Evidence. p. 247-270. in C. Hu (eds.), Forensic Entomology. Chongqing Publishing House, Chongqing, China. 3. Tang, J., S. Li and Y. Chen. 1995. Classification status and history. p. 1-4. in J. Tang et al. (eds.), Economic Insect Fauna of China: Hymenoptera: Formicidae. Fasc. 47. Science Press, China. 4. Tang, J., S. Li and Y. Chen. 1995. Morphology and biology. p. 4-16. in J. Tang et al. (eds.), Economic Insect Fauna of China: Hymenoptera: Formicidae. Fasc. 47. Science Press, China. 5. Tang, J., S. Li and Y. Chen. 1995. Economic significance and control. p. 16-21. in J. Tang et al. (eds.), Economic Insect Fauna of China: Hymenoptera: Formicidae. Fasc. 47. Science Press, China. 6. Tang, J. and Y. Chen. 1995. Ant species of Ponerinae, Dorylinae and Leptanillinae. p. 23-45. in J. Tang et al.(eds.), Economic Insect Fauna of China: Hymenoptera: Formicidae. Fasc. 47. Science Press, China. 7. Huang, E. and Y. Chen. 1995. Ant species of Dolichoderinae. p.85-93. in J. Tang et al. (eds.), Economic Insect Fauna of China: Hymenoptera: Formicidae. Fasc. 47. Science Press, China.