biography
Dr. Bin Gong completed his M.D. and then received his PhD from Second Military Medical University, Shanghai, China. He worked as a Visiting Surgeon in the department of Surgery and National Institute of Thoracic Surgery at Changhai Hospital, Second Military Medical University, Shanghai, China. He was also an Exchange Visiting Scientist at Biomedical Engineering Center, UTMB, Texas. At Present he is an Assistant Professor in the department of Pathology, University of Texas Medical Branch, United States.
Area of Interest
1. Functional role of small noncoding RNA in infectious diseases.
2. Identification and Characterization of novel druggable target in host during infectious diseases.
3. Application of Atomic Force Microscopy in infectious disease research.
top publication
1. Yang LQ, Yu WF, Cao YF, GONG B, Chang Q, Yang GS. Potential inhibition of cytochrome P450 3A4 by propofol in human primary hepatocytes. World Journal of Gastroenterology. 2003 9:1959-62.
2. GONG B, Boor PJ. The role of amine oxidases in xenobiotic metabolism. Expert Opinion on Drug Metabolism & Toxicology 2006 2:559-71.
3. GONG B, Trent MB, Srivastava D, Boor PJ. Chemical induced, nonlethal, developmental model of dissecting aortic aneurysm. Birth Defects Research Part A: Clinical and Molecular Teratology 2006 76:29-38.
4. Boor PJ, Yang Y, GONG B. Role of the media in vascular injury: Atherosclerosis and dissection. Toxicologic Pathology 2006 34:33-38.
5. GONG B, Asimakis GK, Chen Z, Albrecht TB, Boor PJ, Pappas TC, Bell B, Motamedi M. Whole-body hyperthermia induces up-regulation of vascular endothelial growth factor accompanied by neovascularization in cardiac tissue. Life Sciences 2006 79:1781-8.
6. Xu Y, GONG B, Yang Y, Awasthi YC, Woods M, Boor PJ. Glutathione-S-transferase protects against oxidative injury of endothelial cell tight junctions. Endothelium. 2007 14:333-43.
7. GONG B, Sun J. Sun J, Vargas G, Chang Q, Xu Y, Srivastava D, Boor PJ. Nonlinear imaging study of extracellular matrix in chemical-induced, developmental dissecting aortic aneurysm: evidence for defective collagen type III. Birth Defects Research Part A: Clinical and Molecular Teratology 2008 82:16-24.
8. GONG B, Bell B, Boor PJ, Albrecht TB, Asimakis GK, Motamedi M. Cardiac preconditioning with local laser-induced hyperthermia. Journal of Surgical Research 2008 149:177-83.
9. Xu Y, GONG B, Yang Y, Awasthi YC, Boor PJ. Adenovirus-mediated overexpression of glutathione-s-transferase mitigates transplant arteriosclerosis in rabbit carotid allografts. Transplantation. 2010 89:409-16.
10. Desai MM, GONG B, Chan T, Davey RA, Soong L, Kolokoltsov AA, Sun J. Differential, type I interferon-mediated autophagic trafficking of hepatitis C virus proteins in mouse liver. Gastroenterology. 2011;141(2):674-85.
11. Welte T, Aronson J, GONG B, Mendell N, Rachamallu A, Tesh R, Paessler S, Born W, O’Brien R, Wang T. Vï§4+ T cells suppress Vï§1+ T cell response during West Nile virus infection. FEMS Immunology and Medical Microbiology 2011 Nov;63(2):183-92.
12. Xin L; Shelite TR; GONG B; Soong L; Fang R; Walker DH. Systemic treatment with CpG-B after sublethal rickettsial infection induces mouse death through indoleamine 2,3-dioxygenase (IDO). PLoS One 2012;7(3): e34062.
13. Cao AT , Yao S, GONG B, Elson CO, Cong Y. Th17 cells upregulate polymeric Ig receptor and intestinal IgA and contribute to intestinal homeostasis. Journal of Immunology 2012 Nov;189(9):4666-73. PMCID:PMC3478497
14. Kunkeaw N, Jeon SH, Lee K, Johnson BH, Wongfieng W, Chamgramol Y, GONG B, Leelayuwat C, Lee YS. Cell death/proliferation roles for nc886, a non-coding RNA, in the protein kinase R pathway in cholangiocarcinoma. Oncogen 2012;382-1-10. PMID:22926522.
15. Jeon SH, Lee B, Kunkeaw N, Johnson BH, Holthauzen LMF, GONG B, Leelayuwat C, Lee YS. Characterization of the direct physical interaction of nc886, a cellular non-coding RNA, and PKR. FEBS Letters 2012 Sep:586(19):3477-84. PMID:22986343.
16. Lihoradova O, Kalveram B, Indran SV, Nandadeva L, Juelich TL, Hill TE, Tseng C-TK, GONG B, Fukushi S, Morikawa S, Freiberg AN, Ikegami T. The dominant-negative inhibition of dsRNA-dependent protein kinase PKR increases the efficacy of Rift Valley fever virus MP-12 Vaccine. Journal of Virology. 2012;86(14):7650-7661. PMCID: PMC3416293.
17. GONG B (Corresponding author), Ma L, Liu Y, Gong Q, Shelite T, Bouyer D, Boor PJ, Lee YS, Oberhauser A. Rickettsiae induce microvascular hyperpermeability via phosphorylation of VE-cadherins: Evidence from atomic force microscopy and biochemical studies. PLoS Neglected Tropical Diseases. 2012;6(6):e1699.
18. Cao AT, Yao S, Gong B, Elson CO, and Cong Y. Th17 cells upregulate polymeric Ig receptor and intestinal IgA and contribute to intestinal homeostasis. Journal of Immunology 2012 Nov;189(9):4666-73. PMCID:PMC3478497.
19. Lihoradova OA, Indran SV, Kalveram B, Lokugamage N, Head JA, GONG B, Tigabu B, Juelich TL, Freiberg AN, Ikegami T. Characterization of Rift Valley fever virus MP-12 strain encoding NSs of Punta Toro virus or sandfly fever Sicilian virus. PLoS Neglected Tropical Diseases. 2012;7(4):e2181.PMCID: PMCID: PMC3630143.
20. Indran SV, Lihoradova OA, Phoenix I, Lokugamage N, Kalveram B, Head JA, Tigabu B, Smith JK, Zhang L, Juelich TL, GONG B, Freiberg AN, Ikegami T. Rift Valley fever virus MP-12 vaccine encoding Toscana virus NSs retains the neuroinvasiveness in mice. Journal of General Virology. 2013, Mar 20 (Epub ahead of print). PMID:23515022.
21. Saxena V, Xie G, Li B, Welte T, GONG B, Boor P, Wu P, Tang S, Tesh R, Wang T. A hamster-derived West Nile virus isolate induces persistent renal infection in mice. PLoS Neglected Tropical Diseases. 2013;7(6):e2205.
22. GONG B (Corresponding author), Lee YS, Lee IH, Shelite T, Kunkeaw N, Xu G, Lee K, Jeon SH, Johnson B, Chang Q, Ha T, Mendell N, Cheng X, Bouyer D, Boor P, Ksiazek T, Walker DH. Compartmentalized, functional role of angiogenin during spotted fever group rickettsia-induced endothelial barrier dysfunction: Evidence of possible mediation by host tRNA-derived small noncoding RNAs. BMC Infectious Diseases 2013;13:285. PMID:23800282
23. Ren J, Kolli D, Deng J, Fang R, Xue M, GONG B, Casola A, Garofalo RP, Wang T, Bao X. MyD88 controls human metapneumovirus-induced pulmonary immune responses and disease pathogenesis. Virus Research. 2013;176(1-2):241-50. PMID: 23845303.
24. GONG B (Corresponding author), Shelite T, Mei F, Ha T, Xu G, Chang Q, Hu Y, Wakamiya M, Ksiazek TG, Boor PJ, Bouyer D, Popov V, Chen J, Walker DH, Cheng X. Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses. Proceedings of the National Academy of Sciences USA. 2013;110(48):19615-20.
25. Shelite T, Seito T, Mendell N, GONG B, Xu G, Soong L, Valbuena G, Bouyer D, Walker DH. A Hematogenously Disseminated Orientia tsutsugamsushi-Infected Murine Model of Scrub Typhus. PLoS Neglected Tropical Diseases. 2014;8(7): e2966. doi: 10.1371/journal.pntd.0002966.
26. Soong L, Wang H, Shelite T, Liang Y, Mendell N, Sun J, GONG B, Valbuena G, Bouyer D, Walker DH. Strong type 1, but impaired type 2, immune responses contribute to Orientia tsutsugamushi-induced pathology in mice. PLoS Neglected Tropical Diseases. 2014;8(9):e3191. doi:10.1371/journal.pntd.0003191
27. Cao A, Yao S, GONG B, Nurieva R, Elson C, Cong Y. Interleukin (IL)-21 promotes intestinal IgA response to microbiota. Mucosal Immunology 2015; PMID: 25586558.