Serafim  Papadimitriou

Xiaodong GE

Assistant Professor

biography

Dr. Xiaodong Ge completed his M.D. and then received his Ph.D. from Third Military Medical University, Chongqing, China. In clinical work, he focuses on the diagnosis of gastrointestinal disease, lymphoma, breast disease, respiratory disease, disease in nervous system and autopsy. In research, he focuses on the pathogenesis of liver fibrosis, alcoholic hepatitis, liver cancer, colorectal cancer, gastrointestinal inflammation and bacterial flora alternation in gut. Currently he is an Assistant Professor of the department of Pathology, University of Illinois at Chicago, USA.

 

Area of Interest

Liver fibrosis; Alcoholic hepatitis; Liver cancer; Colorectal cancer; Gastrointestinal inflammation and Bacterial flora alternation in gut.


top publication

1. Ge X, Arriazu E, Magdaleno F, Cruz R D L, Theise N, Nieto N. High Mobility Group Box-1 Participates in the Pathogenesis of Liver Fibrosis. Hepatology. (2016, Submited)
2. Ge X, Antoine DJ, Lu Y, Arriazu E, Klepper A, Leung TM, Branch AD, Fiel MI, Nieto N. High-Mobility Group Box-1 (HMGB1) Participates in the Pathogenesis of Alcoholic Liver Disease (ALD). J. Biol. Chem. 2014; Aug 15;289(33):22672-91. (Scicence - Business eXchange highlighted on July 24, 2014, SciBX 7(28); doi:10.1038/scibx.2014.827)
3. Wang X*, Lopategi A*, Ge X*, Lu Y, Kitamura N, , Urtasun R, Leung TM, Fiel MI, Nieto N. Osteopontin induces ductular reaction contributing to liver fibrosis. Gut. 2014 Nov;63(11):1805-18. Epub 2014 Feb 42014 Feb 4. doi: 10.1136/gutjnl-2013-306373. (* contributed equally)
4. Arriazu E*, Ge X*, Leung TM, Lopategi A, Lu Y, Kitamura N, Urtasun R, Theise N, Nieto N. Signaling via the Osteopontin and High Mobility Group Box-1 axis drives the fibrogenic response to liver injury. Gut. (Accepted, ID:gutjnl-2015-310752). (* contributed equally)
5. Ge X, Leung TM, Arriazu E, Lu Y, Urtasun R, Christensen B, Fiel MI, Mochida S, Sørensen ES, Nieto N. Binding of osteopontin to lipopolysaccharide lowers tumor necrosis factor-α and prevents early alcohol-induced liver injury in mice. Hepatology. 2014; 59(4):1600-1616. (Nature highlighted on November 26, 2013/ January 2014 volume 11 no. 1:3/nrgastro.213.228)
6. Arriazu E, Galarreta M R D, Magdaleno F, Ge X, Rosa L C D L, Oldberg A, Nieto N. cartilage oligomeric matrix protein participates in the pathogenesis of liver fibrosis. J. Hepatology. (submit).
7. Ge X, Lu Y, Leung TM, Sørensen ES, Nieto N. Milk osteopontin, a nutritional approach to prevent alcohol-induced liver injury by preserving gut integrity. Am. J. Physiol. Gastrointest. Liver Physiol. 2013;304(10):G929-39 (PMID: 23518682).
8. Mormone E, Lu Y, Ge X, Fiel MI, Nieto N. Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice. Gastroenterology. 2012;142(3):612-621.
9. Urtasun R, Lopategi A, George J, Leung TM, Lu Y, Wang X, Ge X, Fiel MI, Nieto N. Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin α(V)β(3) engagement and PI3K/pAkt/NFκB signaling. Hepatology. 2012;55(2):594-608.
10. Leung TM, Lu Y, Yan W, Morón-Concepción JA, Ward SC, Ge X, Conde de la Rosa L, Nieto N. Argininosuccinate synthase conditions the response to acute and chronic ethanol-induced liver injury in mice. Hepatology. 2012;55(5):1596-1609.
11. Ni B, Shi SG, Ge X, KL Cheng. Lessons from the diagnosis and treatment of spontaneous vertebral arterial dissection: case report. Interventional Neuroradiology. 2009;15(2):203-208
12. Ge X, Yang YLi, Duan GJ, et al. In vitro and in vivo biological function of p48—a new type of lipopolysaccharide binding protein. (Chinese Edition) Acta Academiae Medicinae Militaris Tertiae, 2008; 30(2): 142-145.
13. Zou J*, Ge X*, Yang YL, et al. Expression and characterization of disulfide stabilized Fv fragment antibody against N-teminatal fragment of human Lipopolysacc- haride Binding Protein. (Chinese Edition) Acta Academiae Medicinae Militaris Tertiae, 2008; 30(14): 1308-1311. (* contributed equally)
14. Ge X, Zhou J, Liu YS, et al. Preparation and characterization of human Fab antibody to N terminal fragment of human lipopolysaccharide binding protein. (Chinese Edition) Chin J Cell Mol Immunol, 2007; 23(4): 359-362.
15. Ge X, Zhou J, Yang YL, et al. Reconstruction,expression and characterization of dsFv VL of human antibody to N terminal fragment of human lipopolysaccharide binding protein. (Chinese Edition) Acta Academiae Medicinae Militaris Tertiae, 2007; 29(14): 1364-1367.
16. Ge X, Liu YS, Yang YL, et al. Reconstruction and expression of human cathelicidin LL-37 in prokaryotic cell. (Chinese Edition) Acta Academiae Medicinae Militaris Tertiae, 2006; 28(7): 636-639.
17. Yang YL*, Ge X*, Zou J, et al. comparing and contrast two kinds of construction and expression method of reconstructed human cathelicidin LL-37. (Chinese Edition) Acta Academiae Medicinae Militaris Tertiae, 2006; 28(20): 2020-2023. (* contributed equaly)
18. Ge X, Liu YS, Wang XD. Construction of human phage antibody library and screening, identification of antibodies against N terminal fragment of human lipopolysaccharide binding protein. (Chinese Edition) Chin J Cell Mol Immunol, 2005; Mar, 21(2): 180-184.
19. Deng J , Liu YS , Ge X, et al., Preliminary investigation of the gene expression of Tbx3 in human breast carcinoma tissues and the related signif icance. Med J Chin PLA, 2005, 30 (6 ):5 512-514.
20. Wang CS*, Liu YS, Ge X*, et al., Construction of Single Chain Antibody Library Against Human NH-lipopolysac- charide Binding Protein( NH-LBP) and in Vitro Expression of NH-LBP Antibody. Chin J Biologicals, 2005, 18 (3): 177-181. (* contributed equaly)
21. Ge X*, Liu YS, Wang XD*, et al. Expression and Purification of human N terminal lipopolysaccharide binding protein by insect sf21 or sf9 cells and study of its biological function. (Chinese Edition) Acta Academiae Medicinae Militaris Tertiae, 2004; 26(22): 2029-2032.
22. Wang XD, Liu YS, Ge X, et al. Study on the protective effect of recombinant human N-terminal lipopolysaccharide binding protein in mice challenged with LPS. (Chinese Edition) Chin J Burns, 2004; 20(1): 26-29.
23. Ge X, Liu YS, Wang XD, et al. The purification and isolation of a new type of rabbit-origin lipopolysaccharide binding protein and the study of its biological function in vitro. (Chinese Edition) Chin J Burns, 2003; 19(1): 42-46
24. Ge X, Liu YS, Wang XD, et al. A study of the extraction and purification of rabbit lipopolysaccharide-binding protein and its biological function in vitro. (Chinese Edition) Acta Academiae Medicinae Militaris Tertiae, 2003; 25(6): 514-518.
25. Liu YS*, Ge X*, Wang XD, et al. Purification and Isolation of two type lipopolysaccharide binding proteins from the serum of rabbits burned with endotoxemia and study of their difference of biological function in vitro. (Chinese Edition) Chin J Clinical Experimental Pathology, 2003, 19(3):300-306. (* contributed equaly)
26. Ma Li, Wang XD, Ge X, et al. Recombination and expression of Endotoxin binding peptide in E.coil. (Chinese Edition )Medical J Chin people’s Liberation Army. 2003, 28(4): 302-304.
27. Wang XD, Liu YS, Ge X, et al. Cloning of human truncated lipopolysaccharide binding protein gene and construction of its baculovirus expression vector. (Chinese Edition) Acta Academiae Medicinae Militaris Tertiae, 2001, 23(6):637-640.