Hany Emary obtained his Ph.D. degree from Bonn University in medicinal chemistry and drug design discipline. He was engaged in developing new methodologies for selectivity analysis among different promising biological targets. He was supported for7 projects by Taibah University for developing novel compounds of potential anticancer and antimicrobial activities. Until now, twenty full articles were published in scientific peer reviewed journals.
His research interest was trapped amongOrganic and Medicinal Chemistry including: synthesis and biological evaluation of heterocyclic compounds,Cheminformatics: Design and evaluation of different ligand- based virtual screening approaches like 2D fingerprints in similarity searching, structure-activity/selectivity relationship analyses, and fragment-based drug discovery.In addition, molecular modelling: Protein structure prediction and sequence analysis.
1. Saber E-S. Barakat, Mohamed A.A. El-Zahabi, Ashraf A. Abdel- Rahman, Ashraf H. Bayomi, Monir A-S. Amin, Ahmed H. E. A. Synthesis of some new Dibenz[c, e] azepine-5,7-diones of Expected Antihyperlipidemic Activity. JKAU-Medical Sciences, 2007, 14, 3-17.
2. Ahmed H. E. A., Stumpfe D., Vogt I. and Bajorath, J. Meth- ods for computer-aided chemical biology, part 1: design of a bench- mark system for the evaluation of compound selectivity. Chem. Biol. Drug Des. 2007, 70, 182-194.
3. Vogt I., Ahmed H. E. A., Stumpfe D., and Bajorath, J. Methods for computer-aided chemical biology, part 2: evaluation of compound selectivity using 2D fingerprints. Biol. Drug Des. 2007, 70, 195-205.
4. Vogt, I., Ahmed H. E. A., Auer J., Bajorath, J. Exploring structure selectivity relationships of biogenic amine GPCR antag- onists using similarity searching and dynamic compound mapping. Mol. Div., 2008, 12, 25-40.
5. Ahmed H. E. A., Geppert H., Stumpfe D., Lounkine E. and Bajorath, J. Methods for computer-aided chemical biology. Part 4: selectivity searching for ion channel ligands and mapping of molecular fragments as selectivity markers. Chem. Biol. Drug Des. 2008, 73, 273-282.
6. Ahmed H. E. A. and Bajorath J. Methods for computer-aided chemical biology. Part 5: Rationalizing the selectivity of cathepsin inhibitors on the basis of molecular fragments and topological feature distributions. Chem. Biol. Drug Des. 2009, 74, 129-141.
7. Ahmed H. E. A., Vogt M., and Bajorath J. Design and evalua- tion of bonded atom pair descriptors. J. Chem. Inf. Model., 2010,50, 487-499.
8. Elagawany, Mohamed, Ahmed H. E. A. et al. Design, synthesis, and molecular modelling of pyridazinone and phthalazinone derivatives as protein kinases inhibitors. Bioorganic & Medicinal Chemistry Letters, 2013, 23, 2007-2013.
9. Mohamed F. Zayed, Ahmed H. E. A., Abdel-Sattar M. Omar, Adel S. Abdelrahim, Khaled El-Adl. Design, synthesis, and biological evaluation studies of novelquinazolinone derivatives as anticonvulsant agents. Med Chem Res, 2013, 22,15-23.
10. Ahmed H. E. A., Abdel-Sattar M. Omar, Saleh Ihmaid. 3-Phenylquinoxalin-2 (1H)-one Derivatives as Potential Antimicrobial Agents: Design, Synthesis, and Docking studies. Az. J. Pharm Sci., 2014, 50, 239-256.
11. Sherine N. Khattab, Shimaa A. H. Abdel Moneim, Adnan A. Bekhit, Abdel Moneim El Massry, Seham Y. Hassan, Ayman El-Faham, Ahmed H. E. A.and Adel Amer. Exploring new selective 3-Benzylquinoxaline-based MAO-A inhibitors: Design, Synthesis, biological evaluation and docking studies. European Journal of Medicinal Chemistry, 2015, 24,3537-3550.
12. Ahmed H. E. A., Mohamed F. Zayed, Saleh Ihmaid. Molecular Pharmacophore Selectivity Studies, Virtual Screening, and in Silico ADMET Analysis of GPCR Antagonists. Medicinal chemistry research, 2015, 24, 3537-3550.
13. Mohamed F. Zayed, Ahmed H. E. A., Saleh Ihmaid, Abdel-Sattar M. Omar, Adel S. Abdelrahim.Synthesis and screening of some new fluorinated quinazolinone–sulphonamide hybrids as anticancer agents, Journal of Taibah University Medical Science, 2015, 10, 333-339.
14. Ghareeb D, Khalil S, Hafez HS, Bajorath J, Ahmed H. E. A., Sarhan E, El-Wakeel E & El-Demellawy MA. Berberine reduces neurotoxicity related to non-alcoholic steatohepatitis in rats. Evid Based Complement Alternat Med, 2015, doi:10.1155/2015/361847.
15. MAyoup M. S., Ahmed H. E. A., El Massry A. M., Senior S., Khattab S. N., Hassan S. Y. and Amer A.Synthesis, Docking, and Evaluation of Antimicrobial Activity of a New Series of Acyclo C-Nucleosides of 1, 2, 4-Triazolo[4, 3-a]quinoxaline Derivatives, J. Heterocyclic Chem., 2016, 53, 153-163..
16. Ihmaid SK, Ahmed H. E. A., Zayed MF, Abadleh MM. Self-Organizing Map-Based Classification of Cathepsin k and S Inhibitors with Different Selectivity Profiles Using Different Structural Molecular Fingerprints: Design and Application for Discovery of Novel Hits. Molecules. 2016; 21(2):175.