Jinhui Chen

Associate Professor



Area of Interest

Neural stem cell, neurogenesis, Traumatic Brain Injury

top publication

1. Huashun Li*, Jinhui Chen*, Wei wu*, Tanya Fagaly, Lijuan Zhou, Wenlin Yuan, Sophie Dupuis, Zhihong Jiang, William Nash, Carrie Gick, David M. Ornitz, Jane Y. Wu, Yi Rao. (1999) Vertebrate Slit,a Secreted Ligand for the Transmembrance Protein Roundabout, is a Repellent for Olfactory Bulb Axons. Cell, 96: 807-818 *(equal contribution). PMID: 10102269
2. Wei Wu, Kit Wong, Jinhui Chen, Zhihong Jiang, Jane Y. Wu, Yi Rao. (1999) Directional Guidance of Neuronal Migration in theOlfactory System by the Secreted Protein Slit. Nature (article), 400: 331-336. PMID: 10432110
3. Wenlin Yuan, Lijuan Zhou, Jinhui Chen, Jane Y. Wu, David M. Ornitz. (1999) The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance. Developmental Biology, 212:290-306. PMID: 10433822
4. Jinhui Chen, Wei Wu, Huashun Li, Tanya Fagaly, Lijuan Zhou, Jane Y. Wu, Yi Rao. (2000) Embryonic expression, extracellular secretion, and chemorepulsive activity of Xenopus Slit. Neuroscience, 96: 231-236. PMID: 10683427
5. Jinhui Chen, Leng Wen, Sophie Dupuis, Jane Y. Wu, Yi Rao. (2001) The N- terminal Leucine-Rich Regions in Slit Are Sufficient to Repel Olfactory Bulb Axons and Subventricular Zone Neurons. J of Neuroscience, 21(5): 1548-1556. PMID: 11222645
6. Nicolas O. Fortunel, Hasan Otu, Huck-Hui Ng, Jinhui Chen, Xiuqian Mu, Timothy Chevassut, Xiaoyu Li, Marie Joseph, Charles Bailey, Jacques A. Hatzfeld, Fatih Usta, Vinsensius B. Vega, Philip M. Long, Towia A. Liberman, Bing Lim. (2003) Comment on “Stemness: Transcriptional Profiling of Embryonic and Adult Stem Cells” and “A Stem Cell Molecular Signature” (I). Science. 302, 393. PMID: 14563990
7. Jinhui Chen, Sanjay S. Magavi, Jeffrey D. Macklis. (2004) Neurogenesis of corticospinal motor neurons extending Spinal Projections in adult mice. PNAS, 101, 10357-62. PMID: 15534207
8. Polar Attlota, Bradley J. Molyneaux, Jinhui Chen, Jun Inoue, Ryo Kominami, & Jeffrey D. Macklis. (2005) Neuronal Subtype Specific Genes that Control Corticospinal Motor Neuron Development in vivo. Neuron, 45, 207-21. PMID: 15664173
9. Xiang Gao, Polar Attlota, Jeffrey D. Macklis, Jinhui Chen. (2007) Conditional knok-out of -catenin in postnatal-born dentate gyrus granular neurons results in dendritic malformation. Journal of Neuroscience. 27(52): 14325-14317. PMID: 18160639
10. Xiang Gao, Ying Deng, Wongil Cho, Edwards D. Hall, Jinhui Chen. (2008) Selective death of newborn neurons in hippocampal dentate gyrus following moderate experimental traumatic brain injury. Journal of Neuroscience Research. 86(10):2258-2270. PMID: 18381764
11. Xiang Gao, Enikolopov Grigori, Jinhui Chen. (2008) Direct isolation of neural stem cells in the adult hippocampus after traumatic brain injury. Journal of Neurotruma. 25(8):985-995. PMID: 18665804.
12. Xiang Gao, George Smith, Jinhui Chen (2009) Impaired dendritic development and synaptic formation of postnatal-born dentate gyrus granular neurons in the absence of brain-derived neurotrophic factor signaling. Experimental Neurology. 215, 178-190. PMID: 19014937
13. Xiang Gao, Jinhui Chen (2009) Conditional knockout of brain-derived neurotrophic factor in the hippocampus increases death of adult-born immature neurons following traumatic brain injury. Journal of Neurotrauma. 26, 1325-1335. PMID: 19203227
14. Xiang Gao, Enikolopov Grigori, Jinhui Chen (2009) Moderate traumatic brain injury promotes proliferation of quiescent neural progenitors in the adult hippocampus. Experimental Neurology. 219, 516-523. PMID: 19615997
15. Xiang Gao, Jinhui Chen (2011) Mild traumatic brain injury results in extensive neuronal degeneration in the cerebral cortex. J of Pathology and Experimental Neurology. 70(3): 183-191. PMID: 21293299.
16. Joel M. Brittain, Liang Chen, Tatiana Brustovetsky, Xiang Gao, Nicole M. Ashpole, Sarah M. Wilson, Andy Hudmon, Fletcher A. White, Nikolay Brustovetsky, Jinhui Chen, and Rajesh Khanna. (2011) Neuroprotection against traumatic brain injury by a peptide derived from the collapsin response mediator protein 2 (CRMP-2). J Biological Chemistry. 286(43):37778-92. PMID: 21832084.
17. Xiang Gao, Ping Deng, Zhao C. Xu, Jinhui Chen (2011) Traumatic brain injury causes acute dendritic and synaptic degeneration in hippocampal dentate gyrus PlosOne. 6 (9), e245666-e24566. PMID: 21931758.
18. Chandler L. Walke, Melissa J. Walker, Nai-kui Liu, Emelie C. Risberg, Xiang Gao, Jinhui Chen, and Xiao-Ming Xu. (2011) Bisperoxovanadium promotes neuroprotection and functional recovery after cervical contusive spinal cord injury: a possible mechanism involving Akt/mTOR activation. PlosOne 2012;7(1):e30012. Epub 2012 Jan 10. PMID: 22253859.
19. Hongzhen Zou, Liang Chen, Bingde Luo, Jinhui Chen (2012) Moderate traumatic brain injury triggers rapid necrotic death of immature neurons in the hippocampus. J of Pathology and Experimental Neurology. 71(4): 348-59. PMID: 22437344.
20. Xiang Gao, Jinhui Chen. (2013) Moderate Traumatic Brain Injury Promotes Neural Precursor Proliferation Without Increasing Neurogenesis In The Adult Hippocampus. Experimental neurology. 239: 38-48. PMID: 23022454.
21. Jianguo Hu, Xiaofei Wang, Linxiao Deng, Naikui Liu, Xiang Gao, Jinhui Chen, Fengcheng Zhou, Xiao-Ming Xu. (2013) Co-transplantation of glial restricted precursor cells and Schwann cells promotes functional recovery after spinal cord injury. Neural Transplantation. 22(12): 2219-36. PMID: 23295060. PMID: 23295060.
22. Jinhui Chen, Yiwen Ruan, Kwok Fai So, Xiao-Ming Xu. (2014) Dipping cells in acidic bath could make stem cells. Neural Regeneration Research. 9(6):575-576. PMID: 25206856.
23. Jennifer Romine, Xiang Gao, and Jinhui Chen. (2014) Controlled Cortical Impact Model for Traumatic Brain Injury. Journal of Visualized Experiments. 2014 Aug 5;(90):e51781. PMID: 25145417.
24. Jinhui Chen, Libing Zhou, Su-yue Pan. (2014) A brief review of recent advances in stem cell biology. Neural Regeneration Research. 9(7):684-687. PMID: 25206872.
25. John RG Perry, Felix Day, …Jinhui Chen… (2014) Parent-of-origin specific allelic associations among 106 genomic loci for age at menarche. Nature 514, 92-97. PMID: 25231870.