Wai-Yee CHAN



CHAN, Wai-Yee, Ph.D. is Professor of Biomedical Sciences and Director of School of Biomedical Sciences, the Chinese University of Hong Kong (CUHK), Hong Kong. He obtained his B.Sc. from the Chinese University of Hong Kong and Ph.D. in Biochemistry from the University of Florida, Gainesville, Florida, USA. Prior to returning to Hong Kong in 2009, he was a tenured Professor, Department of Pediatrics, Georgetown University, Washington, DC, USA. In 2001, he helped the U.S. National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), to found the Laboratory of Clinical Genomics. He was later appointed as Head and Principal Investigator of the Section on Developmental Genomics, NICHD. He was a past president and is currently the Executive Director of the Association of Chinese Geneticists in America. He is also a member of the Academic and Technical Committee of the National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, Shandong, China. He is a recipient of the 1988 Merrick Award for Outstanding Biomedical Research from the Oklahoma Medical Research Founda¬tion and the 2008 Presidential Award from the Association of Chinese Geneticists in America. He is also a member of the Shaw Prize Council.


Area of Interest

Functional genomics and epigenetic regulation of germ cell and gonad development in health and diseases, molecular genetics of heritable human reproductive and endocrine disorders, non-coding RNAs (antisense transcript and microRNA) in normal and abnormal development, molecular biology of pregnancy proteins, and heritable metabolic disorders of copper.

top publication

1. Ho WKK, Chan WY. Serum lipid and lipoprotein levels in normal Chinese. Clin Chim Acta. 7:149 154, 1974.
2. Ho WKK, Chan WY. Evaluation of serum lipid and lipopro¬tein levels in normal Chinese. The influence of dietary habit, body weight, exercise and familial record of coronary heart disease. Clin Chim Acta. 61:19 25, 1975.
3. Garnica AD, Chan WY, Rennert OM. The role of the metal¬lothioneins in intracellular copper transport: Studies using skin fibroblasts of patients with Menkes\' Syndrome. Ann Clin Lab Sci. 8:302 309, 1978.
4. Chan WY, Garnica AD, Rennert OM. Metal binding studies of metal¬lo¬thioneins in Menkes\' Kinky Hair Disease. Clin Chim Acta. 88:221 228, 1978.
5. Chan WY, Garnica AD, Rennert OM. Cell culture studies of Menkes\' Kinky Hair Disease. Clin Chim Acta. 88:495 507, 1978.
6. Chan WY, Seale TW, Shukla JB, Rennert OM. Polyamine conjugates and total polyamine concentration in human amniotic fluid. Clin Chim Acta. 91:233 242, 1979.
7. Chan WY, Garnica AD, Rennert OM. Inducibility of metallothionein biosynthesis in cultured normal and Menkes\' Kinky Hair Disease fibroblasts: Effects of copper and cadmium. Pediat Res. 13(4):197 203, 1979.
8. Rennert OM, Chan WY. Menkes\' metallothionein and copper metabolism. Pediat Res. 13(4):204 -205, 1979.
9. Seale TW, Chan WY, Shukla JB, Rennert OM. Isolation and characterization of a polyamine peptide conjugate from human amniotic fluid. Clin Chim Acta. 95:461 472, 1979.
10. Seale TW, Chan WY, Shukla JB, Rennert OM. A polyamine-peptide conjugate isolated from normal human plasma. Arch Biochem Biophys. 189:164 174, 1979.
11. Chan WY, Seale TW, Rennert OM. Fluorescence micro-disc electrophoresis in sodium dodecylsulfate: A simple and sensitive method applicable for routine laboratory analysis. J Chromat. 181(2):259- 265, 1980.
12. Chan WY, Cushing W, Coffman MA, Rennert OM. Genetic expression of Wilson\'s Disease in cell culture: A diagnostic marker. Science. 208:299 300, 1980.
13. Rennert OM, Chan WY, Hildago H, Cushing W, Griesmann GE. Polyamines in Menkes\' Kinky Hair Disease. Clin Chim Acta. 103:375 380, 1980.
14. Chan WY, Rennert OM. Comparative study of Menkes\' and Wilson\'s Disease. Cien Biol. 5(2):73 75, 1980.
15. Chan WY, Richichi J, Griesmann GE, Cushing W, Kling OR, Rennert OM. Copper and ceruloplasmin activity in human amniotic fluid. Am J Obstet Gynecol. 138(3):257 259, 1980
16. Chan WY, Ramadan TZ, Perlman M, McCaffree MA, Rennert OM. Copper and manganese in the mother and in the neonate. Nutr Rep Internat. 22(6):939 948, 1980.
17. Rennert OM, Chan WY, Griesmann GE. Polyamine peptide conjugates: Proposed functions. Physiol Chem Phys. 12(5):441 ¬450, 1980.
18. Chan WY, Rennert OM. The role of copper in iron metabo¬lism. Ann Clin Lab Sci. 10(4):338 ¬344, 1980.
19. Chan WY, Rennert OM. Cadmium nephropathy. Ann Clin Lab Sci. 11(3):229 238, 1981.
20. Chan WY, Mosca P, Rennert OM. Lithium nephrotoxicity: A review. Ann Clin Lab Sci. 11(4):343 349, 1981.
21. Perlman M, Chan WY, Ramadan TZ, Rennert OM. Urinary polyamine in preterm infants. Clin Chim Acta. 113:1 6, 1981.
22. Chan WY, Chung KW, Bates J, Blomberg LA, Rennert OM. Organ specific zinc deficiency in testicular feminization rats: Hormone¬ me¬tal interaction. Biochem Biophys Res Comm. 102(2):630 ¬635, 1981.
23. Seiler N, Knodgen B, Gittos MW, Chan WY, Griesmann GE, Rennert OM. On the formation of amino acids deriving from spermi¬dine and spermine. Biochem J. 200(1):123 132, 1981.
24. Chan WY, Bates J, Rennert OM. Comparative studies of manganese binding in human breast milk, bovine milk and infant formula. J Nutr. 112(4):642 651, 1982.
25. Chan WY, Rennert OM. Prenatal and postnatal diagnosis of diseases of copper metabolism. Ann Clin Lab Sci. 12(5):372 380, 1982.
26. Griesmann GE, Chan WY, Rennert OM. Determination of gamma aminobutyric acid by reverse ¬phase HPLC and pre column labeling for fluorescence detection. J Chromat. 230:121 124, 1982.
27. Perlman M, Chan WY, Ramadan TZ, McCaffree MA, Rennert OM. Serum copper and ceruloplas¬min in preterm infants: Prospective study. J Am Coll Nutr. 1:155 163, 1982.
28. Liu HC, Chan WY, Rennert OM. Histochemical studies of fibroblasts from patients with Menkes\' Kinky Hair Disease and Wilson\'s Disease. Histochem J. 14:781 789, 1982.
29. Chan WY, Chung KW, Bates JM Jr, LeBlanc M, Tease LA, Griesmann GE, Rennert OM. Zinc metabolism in testicular feminization and cryptorchid testes in rats. Life Sci. 32(11):1279 1284, 1983.
30. Chung KW, Chan WY, Dressler JB, Allison JE, Rennert OM. Androgen receptors in the brain of neonatal normal male and androgen insensitive rats. Biochem Biophys Res Comm. 111(2):717 722, 1983.