Rwik Sen in an early career scientist specializing in epigenetic regulation of health and diseases. He is the recipient of a postdoctoral fellowship award from the American Heart Association. Rwik received an undergraduate degree in Biotechnology as Bachelor of Technology from India. He earned a Ph.D. in Molecular Biology, Microbiology and Biochemistry from the United States, where he is currently pursuing postdoctoral research in developmental biology. During his PhD, Rwik studied transcriptional regulation by epigenetic and DNA repair factors, the ubiquitin-proteasome system, DNA damage repair, and mRNA processing, using Saccharomyces cerevisiae as a model organism. His postdoctoral research involves the roles of epigenetic factors in craniofacial and cardiac development,using zebrafish and human cells. Most of Rwik’s past research has already been published in reputed peer-reviewed journals like Nucleic Acids Research, Journal of Biological Chemistry, Molecular and Cellular Biology, and Journal of Developmental Biology.Rwik has presented his research in several conferences in the United States. In addition to research, he is committed to mentoring, teaching, and science outreach.
Research Interests Epigenetic regulation of transcriptional initiation, elongation, mRNA processing and export Role of ubiquitin-proteasome system in transcription and chromatin dynamics Transcriptional regulation by environmental inorganic phosphate sensing and uptake DNA double-strand breaks repair and its association with transcription Role of histone modifying enzymes in craniofacial development Regulation of cardiac development by epigenetic factors and their disease-specific mutations Epigenetics and transcriptional analysis across species ranging from yeast, zebrafish, humans
Preferential repair of DNA double-strand break at the active gene in vivo. Chaurasia P, Sen R, Pandita TK, Bhaumik SR. The Journal of biological chemistry. 2012; 287(43):36414-22. PubMed [journal] PMID: 22910905 PMCID: PMC3476307
Functional analysis of Rad14p, a DNA damage recognition factor in nucleotide excision repair, in regulation of transcription in vivo. Chaurasia P, Sen R, Bhaumik SR. The Journal of biological chemistry. 2013; 288(2):793-806. PubMed [journal] PMID: 23188830 PMCID: PMC3543029
Functional analysis of Bre1p, an E3 ligase for histone H2B ubiquitylation, in regulation of RNA polymerase II association with active genes and transcription in vivo. Sen R, Lahudkar S, Durairaj G, Bhaumik SR. The Journal of biological chemistry. 2013; 288(14):9619-33. PubMed [journal] PMID: 23417674 PMCID: PMC3617266
Transcriptional stimulatory and repressive functions of histone H2B ubiquitin ligase. Sen R, Bhaumik SR. Transcription. 2013; 4(5):221-6. PubMed [journal] PMID: 24135701
Sus1p facilitates pre-initiation complex formation at the SAGA-regulated genes independently of histone H2B de-ubiquitylation. Durairaj G, Sen R, Uprety B, Shukla A, Bhaumik SR. Journal of molecular biology. 2014; 426(16):2928-2941. NIHMSID: NIHMS604245 PubMed [journal] PMID: 24911582 PMCID: PMC4108552
Rrd1p, an RNA polymerase II-specific prolyl isomerase and activator of phosphoprotein phosphatase, promotes transcription independently of rapamycin response. Sen R, Malik S, Frankland-Searby S, Uprety B, Lahudkar S, Bhaumik SR. Nucleic acids research. 2014; 42(15):9892-907. PubMed [journal] PMID: 25114048 PMCID: PMC4150799 Display Settings: Summary, 20 per page, Sorted by Date (old to new) PubMed 3/15/2019 My Bibliography - My NCBI Collection https://www.ncbi.nlm.nih.gov/myncbi/browse/collection 2/2 7. 8. 9. 10. 11. 12. 13.
Eaf1p Is Required for Recruitment of NuA4 in Targeting TFIID to the Promoters of the Ribosomal Protein Genes for Transcriptional Initiation In Vivo. Uprety B, Sen R, Bhaumik SR. Molecular and cellular biology. 2015; 35(17):2947-64. PubMed [journal] PMID: 26100014 PMCID: PMC4525319
Regulation of Antisense Transcription by NuA4 Histone Acetyltransferase and Other Chromatin Regulatory Factors. Uprety B, Kaja A, Ferdoush J, Sen R, Bhaumik SR. Molecular and cellular biology. 2016; 36(6):992-1006. PubMed [journal] PMID: 26755557 PMCID: PMC4810466
Fine-Tuning of FACT by the Ubiquitin Proteasome System in Regulation of Transcriptional Elongation. Sen R, Ferdoush J, Kaja A, Bhaumik SR. Molecular and cellular biology. 2016; 36(11):1691-703. PubMed [journal] PMID: 27044865 PMCID: PMC4959319
An mRNA Capping Enzyme Targets FACT to the Active Gene To Enhance the Engagement of RNA Polymerase II into Transcriptional Elongation. Sen R, Kaja A, Ferdoush J, Lahudkar S, Barman P, Bhaumik SR. Molecular and cellular biology. 2017; 37(13). PubMed [journal] PMID: 28396559 PMCID: PMC5472824
Two Distinct Regulatory Mechanisms of Transcriptional Initiation in Response to Nutrient Signaling. Ferdoush J, Sen R, Kaja A, Barman P, Bhaumik SR. Genetics. 2018; 208(1):191-205. PubMed [journal] PMID: 29141908 PMCID: PMC5753858
Kat2a and Kat2b Acetyltransferase Activity Regulates Craniofacial Cartilage and Bone Differentiation in Zebrafish and Mice. Sen R, Pezoa SA, Carpio Shull L, Hernandez-Lagunas L, Niswander LA, Artinger KB. Journal of developmental biology. 2018; 6(4). PubMed [journal] PMID: 30424580 PMCID: PMC6315545
Distinct functions of the cap-binding complex in stimulation of nuclear mRNA export. Sen R, Barman P, Kaja A, Ferdoush J, Lahudkar S, Roy A, Bhaumik SR. Molecular and cellular biology. 2019; PubMed [journal] PMID: 30745412