Lehe Mei



Lehe Mei currently holds the position of Professor in the Department of Chemical and Biological Engineering, Zhejiang University Vice Principal (2015-), Ningbo Institute of Technology, Zhejiang University.He received his Ph.D. degree in Biochemical Engineering, Zhejiang University, 2000.he received The SecondProgress Prize in Scientific and Collective Technology of Ningbo award in 2015 and The Second Prize in Scientific and Technology of Zhejiang Province award in 2014 .He has many publications in international scientific journals with high impact factor.


Area of Interest

2. Protein Engineering
3. Fermentation Engineering
4.Cell Engineering
5.Biocatalysis and Biotransformation
6.Separation and Purification of Protein.

top publication

1.pH stabilization of lactic acid fermentation via the glutamate decarboxylation reaction: Simultaneous production of lactic acid and γ-aminobutyric acid. Process Biochemistry, 2015, 50(10): 1523–1527.

2.Permeabilizing Escherichia coli for whole cell biocatalyst with enhanced biotransformation ability from L-glutamate to GABA. Journal of Molecular Catalysis B: Enzymatic, 2014, 17:39–46.

3.C-terminal truncation of glutamate decarboxylase from Lactobacillus brevis CGMCC 1306 extends its activity toward near-neutral pH. Enzyme and Microbial Technology, 2012, 50(4-5):263-269.

4.Altering the regioselectivity of cytochrome P450 BM-3 by saturation mutagenesis for the biosynthesis of indirubin. Journal of Molecular Catalysis B: Enzymatic, 2010, 67(1-2): 29-35.

Application of artificial neural network coupling particle swarm optimization algorithm to biocatalytic production of GABA. Biotechnology and Bioengineering, 2007, 96 (5): 924-931.