He is involved in human movement neurophysiology research since he was a medical student. Since 2008 he collaborate with the Laboratory of Biomedical Robotics and Biomicrosystem at University Campus Bio-Medico of Rome for the development and use of human movement analysis devices in healthy and pathological subjects (Parkinson’s disease patients). He has expertise in the use of Transcranial Magnetic Stimulation and Transcranial direct-current stimulation, and he has used these techniques, for the study of neural networks that underlying kinematic control of redundant movements. From 2011 to 2016 he attended the Neurology Residency Training Program at University Campus Bio-Medico of Rome. In 2011 he designed, organized and implemented an ongoing research protocol for the study of premotor symptoms of Parkinson's disease using an MRI technique, the diffusion tensor imaging (DTI), as a tool for the study of hyposmia in Parkinson’s disease. Recently he has focalized his research activity on the neurophysiological mechanism of Deep Brain Stimulation in Parkinson's disease patients and other movement disorders. He attended as a visiting doctor at Toronto Western Hospital, Movement Disorders Clinic for 4 months in 2015, and since January 2016 he is a clinical research Fellow at Oxford University, Nuffield Department of Clinical Neurosciences and at University College London where he is following a research project on basal ganglia Local Field Potentials recordings of patients who have undergone functional neurosurgery. Finally, in collaboration with Oxford University, Nuffield Department of Clinical Neurosciences and University Campus Bio-Medico of Rome, he is exploring new techniques for differential diagnosis in tremor syndromes.
- Neurodegenerative disease - Parkinson’s disease and other Movement disorders (tremor, ataxia, dystonia, tic, chorea, ballismus) - Tremor analysis - Deep Brain Stimulation. - Local Field Potentials (LFPs) recordings during functional neurosurgery. - Clinical Neurophysiology.
di Biase L, Fasano A. Low-frequency deep brain stimulation for Parkinson's disease: Great expectation or false hope? Mov Disord. 2016 May 13. doi: 10.1002/mds.26658. [Epub ahead of print] Review. PubMed PMID: 27173938.
di Biase, L., Assenza, G., Iorio, R., Melgari, J. M., Salomone, G., Marano, M., Muda, AO, Di Lazzaro, V. (2016). Efficacy of oral corticosteroids therapy in anti-glutamic acid decarboxylase antibodies cerebellar ataxia. Parkinsonism & Related DisordersPetolicchio B, Viganò A, di Biase L, Tatulli D, Toscano M, Vicenzini E, Passarelli F, Di Piero V. Cerebral venous hemodynamic abnormalities in episodic and chronic migraine. Funct Neurol. 2015 May 4:1-6. [Epub ahead of print] PubMed PMID: 27142703.
Marano, M., Salomone, G., di Biase, L., Di Lazzaro, V., & Melgari, J. M. (2015). Reply to letter: Dopamine dysregulation syndrome in Parkinson's disease patients on levodopa–carbidopa intestinal gel. Parkinsonism & related disorders.
Melgari JM., Salomone G., di Biase L., Marano M., Scrascia F., Di Lazzaro V. Dyskinesias during levodopa-carbidopa intestinal gel (LCIG) infusion: Management inclinical practice. Parkinsonism & Related Disorders, 2015.
Melgari JM, Marano M, Quattrocchi CC, Piperno A, Arosio C, Frontali M, Nuovo S, Siotto M, Salomone G, Altavilla R, di Biase L, Scrascia F, Squitti R, Vernieri F. Movement disorders and brain iron overload in a new subtype of aceruloplasminemia. Parkinsonism Relat Disord. 2015 Jun;21(6):658-60. doi: 10.1016/j.parkreldis.2015.03.014. Epub 2015 Mar 19. PubMed PMID: 25864092.
Salomone G, Marano M, di Biase L, Melgari JM, Di Lazzaro V. Dopamine dysregulation syndrome and punding in levodopa-carbidopa intestinal gel (LCIG) infusion: A serious but preventable complication. Parkinsonism Relat Disord. 2015 Jul 21. pii: S1353-8020(15)00307-7.
Melgari JM, Curcio G, Mastrolilli F, Salomone G, Trotta L., Tombini M, di Biase L. et al. "Alpha and beta EEG power reflects L-dopa acute administration in parkinsonian patients."Frontiers in Aging Neuroscience 6 (2014): 302.
Mastrolilli F, Benvenga A, di Biase L, Giambattistelli F, Trotta L, Salomone G, Quintiliani L, Landi D, Melgari JM, Vernieri F. An unusual cause of dementia: essential diagnostic elements of corticobasal degeneration-a case report and review of the literature. Int J Alzheimers Dis. 2011;2011:536141. Epub 2011 Jul 12.
Di Pino G.; Formica D.; Melgari JM.; Taffoni F.; Salomone G.; di Biase L.; Caimo E.; Vernieri F.; Guglielmelli E. Neurophysiological bases of tremors and accelerometric parameters analysis. Biomedical Robotics and Biomechatronics (BioRob), 2012 4th IEEE RAS & EMBS International Conference on , pp.1820,1825, 24-27 June 2012 doi:10.1109/BioRob.2012.6290819