Cheng Chen

Associate Professor


Dr. Cheng Chen is an Associate Professor in Center for Joint Surgery, Southwest Hospital, Third Military Medical University, Chongqing, China. He received the B.S. degree in 2005 in Biomedical Engineering from Southwest University of Science and Technology, Sichuan, China, and the PhD. Degree in 2011 in biomedical engineering from Chongqing University, Chongqing, China. He has many publications in international scientific journals with high impact factor.


Area of Interest

1.Cell and tissue imaging.
2.Cellular biomechanics.
3.Biomaterials and tissue engineering.

top publication

1. Wei-Nan Zeng, Fu-you Wang, Cheng Chen, Ying Zhang, Xiao-Yuan Gong, Kai Zhou, Zhi Chen, Duan Wang, Zong-Ke Zhou, Liu Yang: Investigation of association between hip morphology and prevalence of osteoarthritis. Scientific Reports 5/2016; 6:23477. DOI:10.1038/srep23477.

2. Wei-Nan Zeng, Fu-You Wang, Cheng Chen, Ying Zhang, Jun-Li Liu, Qing-Yu Liu, Hong Tang, Liu Yang: A Novel Dual-Chamber Culture System with Biomimetic Triphasic Scaffold for Osteochondral Tissue Engineering. Journal of Biomaterials and Tissue Engineering 3/2016; 6(3):190-196. DOI:10.1166/jbt.2016.1429

3. Cheng Chen, Li Yin, Xiongbo Song, Hao Yang, Xiang Ren, Xiaoyuan Gong, Fuyou Wang, Liu Yang: Effects of Cytoskeleton Modulation on the Phenotype of Articular Chondrocytes in Monolayer and Pellet Culture. Journal of Biomaterials and Tissue Engineering 12/2015; 5(12):942-950. DOI:10.1166/jbt.2015.1397

4. Li Yin, Cheng Chen, Xiaojun Duan, Bing Deng, Ran Xiong, Fuyou Wang, Liu Yang: Influence of the image levels of distal femur on the measurement of tibial tubercle-trochlear groove distance—a comparative study. Journal of Orthopaedic Surgery and Research 12/2015; 10(1). DOI:10.1186/s13018-015-0323-4

5. Cheng Chen, Li Yin, Xiongbo Song, Hao Yang, Xiang Ren, Xiaoyuan Gong, Fuyou Wang, Liu Yang: Effects of vimentin disruption on the mechanoresponses of articular chondrocyte. Biochemical and

Biophysical Research Communications 11/2015; 469(1). DOI:10.1016/j.bbrc.2015.11.083 6. Cheng Chen, Jing Xie, Ravikumar Rajappa, Linhong Deng, Jeffrey Fredberg, Liu Yang: Interleukin- 1 and tumor necrosis factor- increase stiffness and impair contractile function of articular chondrocytes. Acta Biochimica et Biophysica Sinica 12/2014; 47(2). DOI:10.1093/abbs/gmu116

7. Cheng Chen, Jing Xie, Linhong Deng, Liu Yang: Substrate Stiffness Together with Soluble Factors Affects Chondrocyte Mechanoresponses. ACS Applied Materials & Interfaces 08/2014; 6(18). DOI:10.1021/am504135b

8. Enhua H Zhou, Christa Watson, Richard Pizzo, Joel Cohen, Quynh Dang, Pedro Macul Ferreira de Barros, Chan Young Park, Cheng Chen, Joseph D Brain, James P Butler, Jeffrey W Ruberti, Jeffrey J Fredberg, Philip Demokritou: Assessing the impact of engineered nanoparticles on wound healing using a novel in vitro bioassay. Nanomedicine 05/2014; 9(18):1-13. DOI:10.2217/nnm.14.40

9. Cheng Chen, Dhananjay T. Tambe, Linhong Deng, Liu Yang: Biomechanical properties and mechanobiology of the articular chondrocyte. AJP Cell Physiology 09/2013; 305(12). DOI:10.1152/ajpcell.00242.2013

10. Kaining Chen, Li Yin, Liangjun Cheng, Chuan Li, Cheng Chen, Liu Yang: In vivo motion of femoral condyles during weight-bearing flexion after anterior cruciate ligament rupture using biplane radiography. Journal of sports science & medicine 09/2013; 12(3):579-87.

11. De-Jie Fu, Cheng Chen, Lin Guo, Liu Yang: Use of intravenous tranexamic acid in total knee arthroplasty: A meta-analysis of randomized controlled trials. Chinese Journal of Traumatology (English Edition) 04/2013; 16(2):67-76. DOI:10.3760/cma.j.issn.1008-1275.2013.02.001

12. Changbin Cai, Cheng Chen, Guangxing Chen, Fuyou Wang, Lin Guo, Li Yin, Dehong Feng, Liu Yang: Type I collagen and polyvinyl alcohol blend fiber scaffold for anterior cruciate ligament reconstruction. Biomedical Materials 03/2013; 8(3):035001. DOI:10.1088/1748-6041/8/3/035001

13. Yanling Shi, Yuhui Dong, Yiyuan Duan, Xuemei Jiang, Cheng Chen, Linhong Deng: Substrate stiffness influences TGF-beta 1-induced differentiation of bronchial fibroblasts into myofibroblasts in airway remodeling. Mol Med Rep 7:419-424. Molecular Medicine Reports 12/2012; 7(2). DOI:10.3892/mmr.2012.1213

14. Naimish R Patel, Medhavi Bole, Cheng Chen, Charles C Hardin, Alvin T Kho, Justin Mih, Linhong Deng, James Butler, Daniel Tschumperlin, Jeffrey J Fredberg, Ramaswamy Krishnan, Henry Koziel: Cell Elasticity Determines Macrophage Function. PLoS ONE 09/2012; 7(9):e41024. DOI:10.1371/journal.pone.0041024

15. Diane R Bielenberg, Abhishek Seth, Akio Shimizu, Kristine Pelton, Vivian Cristofaro, Aruna Ramachandran, Bernadette M M Zwaans, Cheng Chen, Ramaswamy Krishnan, Meetu Seth, Lin Huang, Seiji Takashima, Michael Klagsbrun, Maryrose P Sullivan, Rosalyn M Adam: Increased Smooth Muscle Contractility in Mice Deficient for Neuropilin 2. American Journal Of Pathology

06/2012; 181(2):548-59. DOI:10.1016/j.ajpath.2012.04.013 16. Jimin Xu, Cheng Chen, Xuemei Jiang, Rong Xu, Dhananjay Tambe, Xiaojuan Zhang, Lina Liu, Bo Lan, Kaiyong Cai, Linhong Deng: Effects of micropatterned curvature on the motility and mechanical properties of airway smooth muscle cells. Biochemical and Biophysical Research Communications

11/2011; 415(4):591-6. DOI:10.1016/j.bbrc.2011.10.111 17. Linhong Deng, Xuemei Jiang, Cheng Chen, Aijing Song, Feng Lin: Optically tracking the motion of microbeads to study physical behaviors of the living cell in response to transient stretch or compression. Journal of Innovative Optical Health Sciences 04/2011; 04(02):143-150. DOI:10.1142/S1793545811001368

18. Cheng Chen, Ramaswamy Krishnan, Enhua Zhou, Aruna Ramachandran, Dhananjay Tambe, Kavitha Rajendran, Rosalyn M Adam, Linhong Deng, Jeffrey J Fredberg: Fluidization and Resolidification of the Human Bladder Smooth Muscle Cell in Response to Transient Stretch. PLoS ONE 08/2010; 5(8):e12035. DOI:10.1371/journal.pone.0012035.