Anupam Bishayee

Associate Professor, Assistant Dean & Chair


Dr. Bishayee has 25 years combined experience in pharmaceutical education, research, teaching, and administration. Before joining American University of Health Sciences(Signal Hill, CA) as Founding Chair and Associate Professor of Pharmaceutical Sciences,Dr. Bishayee served as a charter faculty member in the Department of Pharmaceutical Sciences, College of Pharmacy and Research Assistant Professor in the Department of Internal Medicine, College of Medicine at the Northeast Ohio Medical University (Rootstown, OH).

Dr. Bishayee has published 100 original research papers and review articles in high-impact, peer-reviewed journals, such as Biochemical Pharmacology,Biochimica et Biophysica Acta, Cancer Prevention Research, Carcinogenesis, Current Cancer Drug Targets, Cancer Letters, Pharmaceutical Research, and International Journal of Cancer, 10 book chapters, and presented over 25 papers at various national and international scientific meetings. Dr. Bishayee served as special theme-issue guest editor for the Current Pharmaceutical Biotechnology and Currant Cancer Drug Targets. Dr. Bishayee is the Associate Editor-in-Chief of World Journal of Gastroenterologyand Associate Editor of BMC Complementary and Alternative Medicine.He is also currently serving as an editorial board member of several reputed journals, including Anti-Cancer Drugs,American Journal of Cancer Science, Chemoprevention, Journal of Carcinogenesis and Mutagenesisand World Journal of Hepatology, and ad-hoc reviewer of more than 50peer-reviewed scientific journals, including Nature Reviews. Dr. Bishayee has received several research awards, including “Young Investigator” award (Indo-American Society of Nuclear Medicine and Dublin Institute of Technology, Ireland), “Younger Scientist” award (National Science Council, Canada and Indian Chemical Society), as well as “most cited”, “most accessed” and “high-impact” articles in Cancer Prevention Research, Molecular Nutrition and Food ResearchandWorld Journal of Hepatology, respectively. He is an active member of various organizations devoted to scientific research and pharmacy education.


Area of Interest

1. Cancer chemoprevention and chemotherapy by dietary agents and phytochemicals
2. Biochemical and pharmacological effects of medicinal plants
3. Radiopharmaceutical therapy

top publication

1. Parikh, N.R., Mandal, A., Bhatia, D., Siveen, K.S., Sethi, G., Bishayee, A.: Oleanane triterpenpoids in the prevention and therapy of breast cancer: current evidence and future perspectives. Phytochemistry Reviews – in press (2014)

2. Sinha, D., Dutta K., Ganguly K.K., Biswas, J., Bishayee A.: A novel synthetic oleanane triterpenoid suppresses adhesion, migration and invasion of highly metastatic melanoma cells by modulating gelatinase signaling axis. Molecular Carcinogenesis – in press (2014)

3. Bishayee, A., Mandal, A.: Trianthema portulacastrum Linn. exerts chemoprevention of 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis in rats. Mutation Research – Fundamental and Molecular Mechanisms of Mutagenesis – in press (2014)

4. Mandal, A., Bhatia, D., Bishayee, A.: Suppression of inflammatory cascade is implicated in methyl amooranin-mediated inhibition of experimental mammary carcinogenesis. Molecular Carcinogenesis – in press (2014)

5. Shanmugam, M.K., Dai, X., Kumar, A.P., Tan, B.K., Sethi, G., Bishayee, A.: Oleanolic acid and its synthetic derivatives for the prevention and therapy of cancer: preclinical and clinical evidence. Cancer Letters 346: 206-216 (2014)

6. Sivaraman Siveen, K., Sikka, S., Surana, R., Dai, X., Zhang, J., Kumar, A.P., Tan, B.K., Sethi, G., Bishayee, A.: Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors. Biochimica et Biophysica Acta - Reviews on Cancer 1845: 136-154 (2014)

7. Mandal, A., Bhatia, D., Bishayee, A.: Simultaneous disruption of estrogen receptor and Wnt/-catenin signaling is involved in methyl amooranin-mediated chemoprevention of mammary gland tumorigenesis in rats. Molecular and Cellular Biochemistry 384: 239-250 (2013)

8. Hou, I.C., Amarnani, S., Chong, M.T., Bishayee, A.: Green tea and the risk of gastric cancer: epidemiological evidence. World Journal of Gastroenterology 19: 3713-3722 (2013)

9. Bhattacharyya, P., Bishayee, A.: Ocimum sanctum Linn. (Tulsi): an ethnomedicinal plant for the prevention and treatment of cancer. Anti-Cancer Drugs 24: 659-666 (2013)

10. Harlev, E., Eviatar, N., Solowey, E., Bishayee, A.: Cancer preventive and curative attributes of plants of the Cactaceae family: a review. Planta Medica 79: 713-722 (2013)

11. Bishayee, A., Mandal, A., Thoppil, R. J., Darvesh, A.S., Bhatia, D.: Chemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancer. International Journal Cancer 133: 1054-1064 (2013)

12. Shanmugam, M.K., Dai, X., Kumar, A.P., Tan, B.K., Sethi, G., Bishayee, A.: Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies. Biochemical Pharmacology 85: 1579-1587 (2013)

13. Bhatia, D., Thoppil, R. J., Mandal, A., Samtani, K.A., Darvesh, A.S., Bishayee, A.: Pomegranate bioactive constituents suppress cell proliferation and induce apoptosis in an experimental model of hepatocellular carcinoma: role of Wnt/β-catenin signaling pathway. Evidence-Based Complementary and Alternative Medicine 2013: 371813 (2013)

14. Darvesh, A.S., Bishayee, A.: Chemopreventive and therapeutic potential of tea polyphenols in hepatocellular cancer. Nutrition and Cancer 65: 329-344 (2013)

15. Thoppil, R.J., Harlev, E., Mandal, A., Nevo, E., Bishayee, A.: Antitumor activities of extracts from selected desert plants against HepG2 human hepatocellular carcinoma cells. Pharmaceutical Biology 51: 668-674 (2013)

16. Bishayee, A., Thoppil, R.J., Mandal, A., Darvesh, A.S., Ohanyan, V., Meszaros, J.G., Háznagy-Radnai, E., Hohmann, J., Bhatia, D. Black currant phytoconstituents exert chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis by suppression of the inflammatory response. Molecular Carcinogenesis 52: 304-317 (2013)

17. Sinha, D., Biswas, J., Bishayee, A.: Nrf2-mediated redox signaling in arsenic carcinogenesis: a review. Archives of Toxicology 87: 383-397 (2013)

18. Bishayee, A., Thoppil, R.J., Darvesh, A.S., Ohanyan, V., Meszaros, J.G., Bhatia, D.: Pomegranate phytoconstituents blunt the inflammatory cascade in a chemically induced rodent model of hepatocellular carcinogenesis. Journal of Nutritional Biochemistry 24: 178-187 (2013)

19. Sinha, D., Biswas, J., Sung, B., Aggarwal, B.B., Bishayee, A.: Chemopreventive and chemotherapeutic potential of curcumin in breast cancer. Current Drug Targets 13: 1799-1819 (2012)

20. Bishayee, A.: Editorial: recent advances in the prevention and therapy of hepatocellular carcinoma. Current Cancer Drug Targets 12: 1043-1044 (2012)

21. Bishayee, A., Darvesh, A.S.: Angiogenesis in hepatocellular carcinoma: a potential target for chemoprevention and therapy. Current Cancer Drug Targets 12: 1095-1118 (2012)

22. Thoppil, R.J, Bhatia, D., Barnes, K.F., Háznagy-Radnai, E., Hohmann, J., Darvesh, A.S., Bishayee, A.: Black currant anthocyanins abrogate oxidative stress through Nrf2-mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma. Current Cancer Drug Targets 12: 1244-1257 (2012) 9 23. Bishayee, A., Thoppil, R.J., Waghray, A., Kruse, J., Novotny, N.A., Darvesh, A.S.: Dietary phytochemicals in the chemoprevention and treatment of hepatocellular carcinoma: in vivo evidence, molecular targets, and clinical relevance. Current Cancer Drug Targets 12: 1191-1232 (2012)

24. Darvesh, A.S., Carroll, R.T., Bishayee, A., Novotny, N.A., Geldenhuys, W.J., Van der Schyf, C.J.: Curcumin and neurodegenerative diseases: a perspective. Expert Opinion on Investigational Drugs 21: 1123-1140 (2012)

25. Gopalan, A., Reuben, S., Shamima, A., Darvesh, A.S., Hohmann, J., Bishayee, A.: The health benefits of black currants. Food and Function 3: 795-809 (2012)

26. Sloan Stakleff, K., Sloan, T., Blanco, D., Marcanthony, S., Booth, T.D., Bishayee, A.: Resveratrol exerts differential effects in vitro and in vivo against ovarian cancer. Asian Pacific Journal of Cancer Prevention 13: 1333-1340 (2012)

27. Harlev, E., Nevo, E., Lansky, E.P., Ofir, R., Bishayee, A.: Anticancer potential of aloes: antioxidant, antiproliferative and immunostimulatory attributes. Planta Medica 78: 843-852 (2012)

28. Harlev, E., Nevo, E., Lansky, E.P., Lansky, S., Bishayee, A.: Anticancer attributes of desert plants: a review. Anti-Cancer Drugs 23: 255-271 (2012)

29. Reuben, S., Gopalan, A., Petit, D.M., Bishayee, A.: Modulation of angiogenesis by dietary phytoconstituents in the prevention and intervention of breast cancer. Molecular Nutrition and Food Research 56: 14-29 (2012)

30. Bishayee, A.: Editorial: current advances in cancer prevention and treatment by natural products. Current Pharmaceutical Biotechnology 13: 115-116 (2012)