Prof. Dr. Yusuf TUTAR is the Head of Biochemistry Division and Basic Pharmaceutical Science Department at Faculty of Pharmacy, Cumhuriyet University, Sivas Turkey. Dr. Tutar is also the Head of Biomedical Engineering Program at the same university. He obtained his MSc and PhD at Oregon State University and Texas Tech University respectively. He pursued his postdoctoral study at National Institutes of Health (NIH/NIDDK), USA. His research focuses on Biochemistry, Biophysics, Genetics and Molecular Biology with specialization in the fields of protein structure-function, protein folding, prion, microrna, pseudogenes, molecular cancer, proteomics, genomics, protein expression and characterization by spectroscopic and calorimetric methods.
• Molecular Cancer Research and epigenetic (RT-PCR and Microarray).
• MicroRNA, pseudogenes, and transfection.
• Prion, translation termination in eukaryotes, and transcription initiation in prokaryotes.
• Investigating structure-function relationship of biological macromolecules with biochemical, biophysical, genetics and molecular biological methods.
1. Heat Shock Protein 90 Inhibition in Cancer Drug Discovery: From Chemistry to Futural Clinical Applications. Anticancer Agents in Medicinal Chemistry, 2015. [Epub ahead of print]. Ozgur A,Tutar Y.
2. Therapeutic Targeting of microRNAs in Cancer: Future Perspectives. Drug Development Research, 2015. [Epub ahead of print] Tutar L, Tutar E, Ozgur A, Tutar Y.
3. Pyrazole Derivatives as Kinase Inhibitors. Anticancer Agents in Medicinal Chemistry, 2015. [Epub ahead of print]. Tutar Y.
4. A Novel Approach to Inhibit Heat Shock Response as Anticancer Strategy by Coumarine Compounds Containing xxxxThiazole Skeleton. Anticancer Agents in Medicinal Chemistry, 2015. [Epub ahead of print] PMID: 25846761. Koca I, Gumus M, Ozgur A, Disli A, Tutar Y.
5. Isolation and characterization of Heat Shock Protein 100 from Toxoplasma gondii RH Strain. Experimental Parasitology, 2015 Feb 26;153:91-97. doi: 10.1016/j.exppara.2015.02.007. [Epubahead of print] PMID:25728232 Coskun KA, Tutar Y.
6. Acyl Thiourea Derivatives Containing Pyrazole Ring Selective Targeting of Human Aurora Kinases in Breast and xxxxBone Cancer. Letters in Drug Design & Discovery Vol. 12, 1, 2015. Ozgur A, Yenidunya E, Koca Ä°, Tutar Y.
7. Prion; Mechanism and Function-Editorial. Current Pharmaceutical Biotechnology, 2014, Vol. 15, No. 11. Tutar Y.
8. Regulation of Heat Shock Proteins by miRNAs in Human Breast Cancer. MicroRNA Vol. 3, No.2, 2014. Ozgur A, Tutar L, Tutar Y.
9. Heat Shock Protein 90 Inhibitors in Oncology. Current Proteomics.2014 July;11 (2):1-9. Aykut O, Tutar Y.
10. Controlled Release and Drug Delivery in Diseases-Editorial. Protein and Peptide Letters. 2014, 21 (11):1. Tutar Y.
11. miRNA and Cancer;computational and experimental approaches Curr Pharm Biotechnol. 2014, 15 (5):429. Tutar Y.
12. miRNA and Cancer; an overview. Curr Pharm Biotechnol. 2014, 15 (5):430-437. Tutar L, Tutar E, Tutar Y.
13. Synthesis, molecular docking, and antitumoral activity of alnustone-like compounds against estrogen receptor alpha-positive human breast cancer. 2014, DOI: 10.3906/kim-1408-72. KüçükoÄŸlu K, Seçinti H, Özgür A, Seçen H, Tutar Y.
14. The Relation Between microRNA 221, 222, 146b and p27Kip1 Protein mRNA Secretions and Clinicopathological xxxxxParameters in Thyroid Cancers and the Alteration of miRNA Secretion in the presence of Hashimoto Thyroiditis. Experimental and Clinical Endocrinology & Diabetes.2014 Mar;122(3):137-143. Acibucu F, Dokmetas S, Tutar Y., Elagoz S, Kilicli F.
15. Dynamic Fluctuations Provide the Basis of a Conformational Switch Mechanism in Apo Cyclic AMP Receptor Protein. Plos Computational Biology. 2013 Jul;9(7): e1003141. Fas B.A., Tutar Y., Haliloglu T.