biography
Subrata Shaw was born in West Bengal, India, and graduated with a B.Sc from the University of Calcutta in 2005 with honors in chemistry with distinction. He started his masters program at the Indian Institute of Technology Kanpur in the summer of 2005. During his masters study he received fellowship awarded by the Brockhouse Institute of Material Research at McMaster University and enrolled in summer research program with Prof. John E. Greedam at McMaster University, Ontario, Canada. After finishing his masters degree in 2007 as a valedictorian he joined the graduate program at Oregon State University, Corvallis, USA. His graduate studies were carried out under the supervision of Prof. James D. White. The focus of his research was to design and synthesis of novel catalysts for asymmetric organic transformations leading to important pharmaceuticals. He obtained his Ph.D. in January 2014 and joined as a postdoctoral fellow in the laboratory of Prof. Stephen W. Fesik at the Vanderbilt University Medical Center, Nashville, USA in the field of cancer drug discovery. Recently, he was promoted to the post of Research Assistant Professor with Prof. Fesik.
Area of Interest
My research interest includes
Medicinal Chemistry
Structure-guided Drug Discovery
Cancer Chemistry
Anti-apoptotic protein.
top publication
1. Shaw, S.; Bian, Z.; Lee, T.; Zhao, B.; Tarr, J. C.; Goodwin, C. M.; Vigil, D.; Goodwin, C. M.; Arnold, A. L.; Sensintaffer, J. L.; Opferman, J.; Boise, L. H.; Savona, M. R.; Letai, A. J.; Rossanese, O. W.; Olejniczak, E. T.; Fesik, S. W. ‘Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors Using Structure-Based Design’ Nature. Chem. Bio., Submitted.
2. Shaw, S.; White, J. D. ‘Asymmetric Synthesis with Iron-salen Complexes’ Synthesis (special issue), Just Accepted DOI: 10.1055/s-0035-1562103
3. Pelz, N. F.; Bian, Z.; Zhao, B.; Shaw, S.; Tarr, J. C.; Belmar, J.; Greg, C.; Camper, D. V.; Goodwin, C. M.; Zhao, B.; Vigil, D.; Goodwin, C. M.; Arnold, A. L.; Sensintaffer, J. L.; Friberg, A.; Rossanese, O. W.; Lee, T.; Olejniczak, E. T.; Fesik, S. W. ‘Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods’ J. Med. Chem. 2016, 59, 2054 - 2066.
4. Shaw, S.; White, J. D. ‘Regioselective and Enantioselective Addition of Sulfur Nucleophiles to Acyclic α,β,γ,δ-Unsaturated Dienones Catalyzed by an Iron(III)-salen Complex’ Org. Lett. 2015, 17, 4564 - 4567. Article highlighted in Synfacts ‘Asymmetric Iron(III)-Catalyzed Sulfa-Michael Addition of Thiols to Dienone’ 2015, 11, 1177.
5. Burke, J. P.; Bian, Z.; Shaw, S.; Belmar, J.; Zhao, B.; Vigil, D.; Goodwin, C. M.; Friberg, A.; Camper, D. V.; Lee, T.; Olejniczak, E. T.; Fesik, S. W. ‘Discovery of Tricyclic Indoles That Potentially Inhibit Mcl- 1 Using Fragment Based Methods and Structure Based Design’ J. Med. Chem. 2015, 58, 3794 - 3805. Article highlighted in • ACS Chemical Research in Toxicology ‘Quoram-sensing Salmonella Enable Density-dependent Protein Expression Exclusively in Tumors’ June 15, 2015. • VICB Communications ‘New Discoveries in the Search for Mcl-1-targeted Anti-cancer Agents’ April 20, 2015.
6. Shaw, S.; White, J. D. ‘A New Iron-Salen Catalyst for Enantioselective Conia-ene Carbocyclization’ J. Am. Chem. Soc. 2014, 136, 13578 - 13581. Article chosen as the Synfact of the Month ‘Fe(III)-Catalyzed Enantioselective Conia-ene Reaction’ 2014, 10, 1273.
7. White, J. D.; Shaw, S. ‘A New Cobalt-Salen Catalyst for the Asymmetric Cyclopropanation: Synthesis of the Seretonin-Norepinephrin Reuptake Inhibitor (+)-Synosutine’ Org. Lett. 2014, 16, 3880 - 3883. Article highlighted in Synfacts ‘Synthesis of Synosutine via Asymmetric Cyclopropanation’ 2014, 10, 1014.
8. White, J. D.; Shaw, S. ‘Iron Catalyzed Enantioselective Sulfa-Michael Addition: A Four-step Synthesis of the Anti-Asthma Agent Montelukast’ Chem Sci.(Edge Article), 2014, 5, 2200 - 2204. Article highlighted in • ChemistryWorld ‘Four Steps to Asthma Treatment’ March 17, 2014. • Asynt News ‘Reduce Steps to Manufacture Drugs and Save Funds’ April 1, 2014.
9. White, J. D.; Shaw, S. ‘A New Catalyst for the Asymmetric Henry Reaction: Synthesis of β- Nitroethanols in High Enantiomeric Excess’ Org. Lett. 2012, 14, 6270 - 6273. Article chosen as the Synfact of the Month ‘Synthesis of β-Nitroethanols via an Asymmetric Copper Catalyzed Henry Reaction’ 2013, 9, 0281.
10. White, J. D.; Shaw, S. ‘Cis-2,5-Diaminobicyclo[2.2.2]octane, A New Scaffold for Asymmetric Catalysis via Salen-Metal Complexes’ Org. Lett. 2011, 13, 2488 - 2491. Article highlighted in Synfacts ‘New Scaffold for Asymmetric Catalysis via Salen-Metal Complexes’ 2011, 8, 0857. PATENT 11. Lee, T .; Bian, Z.; Belmar, J.; Christov, P. P.; Pelz, N. F.; Shaw, S.; Kim, K.; Tarr, J. C.; Olejniczak, E. T.; Zhao, B.; Fesik, S. W. Substituted Indole Mcl-1 Inhibitors PCT Int. Appl. 2015, WO2015148854 A1 20151001.
12. Shaw, S.; Pelz, N. F.; Bian, Z.; Zhao, B.; Tarr, J. C.; Belmar, J.; Greg, C.; Camper, D. V.; Goodwin, C. M.; Zhao, B.; Vigil, D.; Goodwin, C. M.; Arnold, A. L.; Sensintaffer, J. L.; Friberg, A.; Rossanese, O. W.; Lee, T.; Olejniczak, E. T.; Fesik, S. W. ‘Discovery of Potent 2-Indole-acylsulfonamide Mcl-1 Inhibitors Using Structure Guided Fragment-Based Methods’ 107th American Association for Cancer Research Annual Meeting, New Orelans, LA, United States, April 16 - 20, 2016.
13. Shaw, S.; White, J. D. ‘The Asymmetric Sulfa-Michael Reaction. Catalysis by an Iron(III) Complex’ 7th Pacifichem: International Chemical Congress of Pacific Basin Societies, Honolulu, Hawaii, United States, December 15 - 20, 2015 (invited talk).
14. Shaw, S.; White, J. D. ‘Asymmetric Synthesis with New Metal-salen Complexes’ Yonsung Fine Chemical Co., Seoul, South Korea, October 18, 2015 (invited talk).
15. Shaw, S.; White, J. D. ‘Asymmetric Synthesis with New Metal-salen Complexes’ 116th Korean Chemical Society General Meeting, Daegu, South Korea, October 14 - 16, 2015 (invited talk).