Pushpanathan Muthuirulan

Postdoctoral Researcher


Pushpanathan Muthuirulan is a biologist trained with diverse interdisciplinary research areas.Presently, he is a postdoctoral researcher at the National Institutes of Health, NICHD working in the field of neuroscience, where his research has focused on developing state of art tools to map complex neural circuits that involves visual processing in Drosophila. He has 7 years of research experience in the discovery and development of drug candidates with adequate experience in Omics technologies (genomics, transcriptomics, proteomics and metabolomics) and drug target discovery using flow cytometry. He studied Zoology (BSc and MSc) at the American College and subsequentlygained industry experience as project assistant (2006)in StridesArcolabR&D project onthe development and production of antifungal agents against Candidiasis. He obtained his Ph.D. (2014) in Microbiology from Department of Genetics, School of Biological Sciences at Madurai Kamaraj University, where he had identified a novel antifungal peptide, MMGP1 from marine metagenome and characterized its antifungal mechanismswith therapeutic goal to combat fungal diseases


Area of Interest

Microbiology, Molecular and Cell Biology, Immunology, Biochemistry and Neuroscience

top publication

1. Pushpanathan M and Arun Richard C (2016) Microbial flow Cytometry: An Ideal Tool for Prospective Antimicrobial Drug Development. Analytical Biochemistry: Methods in the Biological Sciences (In Press).

2. Velmurugan G, Ramprasath T, Swaminathan K, Mithieux G, Rajendhran J, Pushpanathan M, Babu DDV, Dinakaran V, Rekha B, Parthasarathy A, Lyon AR, Ramasamy S (2016) Gut microbial degradation of organophosphate insecticides-induces glucose intolerance via gluconeogenesis. Genome Biology (Minor Revision)

3. Pushpanathan M, Pooja S, Gunasekaran P and Rajendhran J (2016) Critical evaluation and compilation of physicochemical determinants and membrane interactions of MMGP1 antifungal peptide. Molecular Pharmaceutics. 13(5), 1656-1667.

4. Pushpanathan M, Manjula A, Sathyavathi S, Gunasekaran P and Rajendhran J (2015) Comparative analysis of microbial diversity in termite gut and termite nest using Ion-sequencing. Current Microbiology

5. Pooja S, Pushpanathan M, Gunasekaran P and Rajendhran J (2015) Cytoskeleton mediated invasion and pathogenecity of Streptococcus agalactiae in rat cardiomyocytes. Plos One 2;10(10): e0139733.

6. Ranjani J, Pushpanathan M, Mahesh A, Niraimathi M, Gunasekaran P and Rajendhran J (2015) Pseudomonas aeruginosa PAO1 induces distinct cell death mechanisms in H9C2 cells and its differentiated form. Journal of Basic Microbiology.

7. Pooja S, Pushpanathan M, Jayashree S, Gunasekaran P and Rajendhran J (2014) Identification of periplasmic α-amlyase from cow dung metagenome by product induced gene expression profiling (pigex). Indian Journal of Microbiology, 1-9.

8. Jayashree S, Pooja S, Pushpanathan M, Rajendhran J, Gunasekaran P (2014) Identification and characterization of bile salt hydrolase genes from the genome of Lactobacillus fermentum MTCC 8711. Applied Biochemistry and Biotechnology, 174.2: 855-866.

9. Dinakaran V, Rathinavel A, Pushpanathan M, Sivakumar R, Gunasekaran P, Rajendhran J (2014) Elevated levels of Circulating DNA in Cardiovascular disease patients: Metagenomic profiling of Microbiome in the Circulation. PLoS ONE, 9(8), e105221.

10. Manjula A, Sathyavathi S, Pushpanathan M, Gunasekaran P and Rajendhran J (2014) Microbial diversity in termite nest, Current Science, (00113891), 106(10).

11. Pushpanathan M, Gunasekaran P and Rajendhran J (2013) Mechanisms of the antifungal action of marine metagenome-derived peptide, MMGP1, against Candida albicans PLoS ONE, 8(7): e69316.

12. Pushpanathan M, Gunasekaran P, Rajendhran J (2013) Proteolytic activity of marine metagenome derived antifungal peptide, MMGP1, International Journal of Peptide Research and Therapeutics, 19(4), 331-336.