biography
Dr. Bo Pan completed his Ph.D. from China Agricultural University, Beijing, China. He worked as a research assistant in the department of Antibody Engineering and Immunology, State Key Laboratory of Pathogen and Biosecurit Beijing Institute of Microbiology and Epidemiology, P R China. He has numerous publications in peer reviewed journals, book chapters, book editing, journal editorial boards and reviewer. In research, he focuses on the pathogenesis of Prion disease, Neurodegenerative diseases, Rabies, Encephalitozoonosis and Avian influenza disease. Currently he is a postdoc of the department of Basic Biomedical Science, University of South Dakota, USA.
Area of Interest
Protein degradation in neurodegeneration, molecular mechanisms of neuroprotection; Molecular mechanisms of progression of various heart diseases to congestive heart failure; Antibody engineering for infectious disease prevention and control, and bacteriophage based prevention and treatment of multi-drug resistance bacterial infections;
top publication
Paper:
1. Yaoqian Pan, Jihong Wang, Ammara Abdullah, Lei Zhang, Yongyao Fu, Jin Wang, Fangfang Qiao, Yigang Tong#, Bo Pan#. Immune of the central nervous system and alteration of microglia play a vital role in Alzheimer’s disease. Neuron. 2016.
2. Lei zhang, Bo Pan, et al. Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors. Molecular oncology. 2016, 10(7): 1099-1117.
3. Yaoqian Pan, Ruiying Liu, Erin Terpstra, Yanqing Wang, Fangfang Qiao, Jin Wang, Yigang Tong#, Bo Pan#. Dysregulation and Diagnostic Potential of microRNA in Alzheimer’s Disease. Journal of Alzheimer’s Disease. 2015, 49(1): 1-12.
4. Yaoqian Pan*, Liying Sun*, Jihong Wang, Wenzhuo Fu, Yongyao Fu, Jin Wang, Yigang Tong#, Bo Pan#. STI571 protects neuronal cells from neurotoxic prion protein fragment-induced apoptosis. Neuropharmacology. 2015, 93: 191-198.
5. Bo Pan*, Lifeng Yang, Jin Wang, et al., c-Abl tyrosine kinase mediates neurotoxic prion peptide-induced neuronal apoptosis via regulating mitochondrial homeostasis, Molecular neurobiology, 2014, 49(2): 1102-1116.
6. Yaoqian Pan*, Bo Pan*, Xingyou Liu, et al., Dicer and Its miRNAs are Necessary Gene and Regulatory Factors for Differentiation and Proliferation of Vascular Smooth Muscle Cell. Progress in Biochemistry and Biophysics, 2014, 41(12): 1255-1264.
7. Yongyao Fu*, Deming Zhao*, Bo Pan, et al., Proteomic Analysis of Protein Expression Throughout Disease Progression in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer’s Disease. 2015, 47(4): 915-926. (Second author)
8. Yunsheng Wang*, Deming Zhao*, Bo Pan, et al., Death receptor 6 and caspase-6 regulate prion peptide-induced axonal degeneration in rat spinal neurons. Journal of Molecular neuroscience. 2015, 56(4): 966-976. (Second author)
9. Jihong Wang*, Deming Zhao*, Bo Pan, et al., Toll-like receptor 2 deficiency shifts prp106-126-induced microglial activation from a neurotoxic to a neuroprotective phenotype. Journal of Molecular neuroscience. 2015, 55(4): 880-890. (Second author)
10. Jin Wang*, Xiangmei Zhou*, Bo Pan, et al., Expression Pattern of Interferon-Inducible Transcriptional Genes in Neutrophils During Bovine Tuberculosis Infection. DNA and Cell Biology. August 2013, 32(8): 480-486. (Second author)
11. Wang Jin*, Zhou Xiangmei*, Pan Bo, et al., Investigation of the effect of Mycobacterium bovis infection on bovine neutrophils functions, Tuberculosis 93(2013): 675-687. (Second author)
12. Pan Bo*, et al., Establishment of standard curve for mouse Bax gene recombinant plasmid using Real-time PCR, progress in veterinary medicine, 2013, 34(12): 64-68.
13. Pan Bo*, et al., Establishment of standard curve for mus musculus Foxo3 gene recombinant plasmid using Real-time qPCR, Chinese Journal of Veterinary Medicine, 2014.
14. Pan Bo*, et al., Construction and identification of an experssing vector for a large human naive phage antibody library, Journal of Capital Medical University, 2012, 33(5): 647-652.
15. Pan Bo*, et al., Phage antibody library technology and its application, Letters in biotechnology, 2010, 21(4): 579-584.
16. Patent: MST1 genes for quantitative detection of the plasmid and the standard kit. Deming Zhao, Lifeng Yang, Bo Pan, et al. (The third completer)
17. Patent: Build quality phage antibody libraries used in the expression vector. Yigang Tong, Xiaoping An, Bo Pan, et al. (The fourth completer)
Books:
18. Chief editor: 《Primary Atlas of diagnosis and therapy of Swine disease》3nd.
19. Associate editor: 《Color Atlas of diagnosis and therapy of Swine disease》2nd.
20. Associate editor: 《Primary Atlas of diagnosis and therapy of Swine disease》2st.
21. Editor: 《Color Atlas of diagnosis and therapy of dairy cattle》1st.
22. proofreading and revision: 《Diseases of Sheep》 1st, 《Veterinary Pathology》 5th, 《Diseases of Swine》 10th.
Grants:
1. The COP9 Signalosome in the Heart (HL085629-10~13), NHLBI/NIH. Grant Role: Participant. (2016 - 2020)
2. Ubiquitin receptors in cardiac proteotoxicity (HL072166-11~14), NHLBI/NIH. Grant Role: Participant. (2014 - 2018)
3. COP9 Signalosome in cardiovascular control. BBS Protein quality control pilot grant. Grant Role: Participant. (2015 - Present)
4. Ubiquitin receptors in cardiac proteotoxicity. (HL072166-11~14), NHLBI/NIH. Grant Role: Participant. (2014 - 2018)
5. c-Abl tyrosine kinase mediates neurotoxic prion peptide-induced neuronal apoptosis and its mechanism. No: 31272532. Grant Role: Participant.
6. Research and product development of molecular diagnosis technology for zoonoses revelent to tuberculosis, brucellosis, chlamydia infection. No: 2012AA101302. Grant Role: Participant.
7. Development of humanized anti-avian influenza virus H5N1 secretory cocktail IgA. No: 2009AA02Z111. Grant Role: Participant.