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Gurudutta Gangenahalli

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Dr.Gurudutta Gangenahalli, FICS, FNA Biol Sci’s, FICI (Ire), FRAM (Ire), FRSC(UK), FRSB (UK), FRSM (UK), presently an Additional Director & Founding Head of the Division of Stem Cell Research at Institute of Nuclear Medicine and Allied Sciences (INMAS), DRDO, Delhi, India. He has made several original & novel discoveries, especially in understanding the therapeutic potential human stem cell fate response signaling, such as Apoptosis, Adherence, Osteogenesis, Differentiation, Homing, by using Genetic-engineering of human stem cell genes (of CD34, BCL-2, CXCR4, PU.1, SCFr/c-Kit, APC, OSx, Wntetc) & by High-throughput gene-expression analysis, and also, developing the human stem cell shielding formulations & NMR stem cell tracking methods. This work constitutes the basis to facilitate the fate modifications strategies, and to develop new and effective fate modifying molecules which enhance stem cell regenerative potentials brining their effective applications closer to bench-to-Bed side, particularly for injury treatment of Defense interest.

 

Area of Interest

Therapeutic potential human stem cell fate response signaling, such as Apoptosis, Adherence, Osteogenesis, Differentiation, Homing, by using Genetic-engineering of human stem cell genes (of CD34, BCL-2, CXCR4, PU.1, SCFr/c-Kit, APC, OSx, Wntetc) & by High-throughput gene-expression analysis, and also, developing the human stem cell shielding formulations & NMR stem cell tracking methods.


top publication

1. Early monitoring and quantitative evaluation of macrophage infiltration after xperimental traumatic brain injury: a magnetic resonance imaging and flow cytometric analysis. Sushanta Kumar Mishra, B. S. Hemanth Kumar, Subash Khushu, Ajai K Singh and Gurudutta Gangenahalli. Molecular and Cellular Neuroscience (Elsevier). 25-34. 78. 2017(IF=3.9)
2. Therapeutic Prospective of Infused Allogenic Cultured MSCs in Traumatic Brain Injury Mice: A longitudinal 1H MRS assessment. Sushant Mishra, Subash Kushu and Gurudutta Gangenahalli*. Stem Cells (Translational Medicine) (Alpha Med, USA). 5, 1-14, 2016.(IF=5.71 2014). (IF=Impact Factor 2016 arrive in 2017). (* Corresponding Author).
3. Potential stem cell labeling ability of poly-L-lysine complexed to ultrasmall iron oxide contrast agent: An optimization and relaxometry study. Sushant Mishra, Subash Kushu and Gurudutta Gangenahalli* (Corresponding Author). Experimental Cell Research (Elsevier), 339, 2, 10,427–436. 2015 (IF=3.246, in 2015). (* Corresponding Author).
4. Gene expression profiling of human c-Kit mutant D816V. Shilpa Sharma, GURUDUTTA Gangenahalli*. Journal of Cancer Therapy(Scientific Research Publishing), 2016, 7, 439-454.(* Corresponding Author).
5. Umbilical Cord Blood Transplantation: Clinical Challenges. Shilpa Sharma and Gurudutta Gangenahalli* (*Corresponding Author).International Journal of Stem Cell Research and Transplantation (Sci Doc Publishers, England), 3 (6),134-141, 2015.
6. Maxillofacial Musculoskeletal Diseases. Manu Krishnan*, Gurudutta Gangenahalli, Satish R. Iyer and Sanjay Londhe.Austin Journal of Musculoskeletal Disorders (2015).2, 2, 1-20, 2015.
7. Adult hematopoietic stem cells: Niche cross-talks to affect the cell. Shilpa Sharma and Gurudutta Gangenahalli* (*Corresponding Author). Niche Journal (Journal of Cellular Therapy & Regenerative Medicine Society. Turkey). DOI:10.5152/Niche.2015.214.
8. Epigenetic regulation of hematopoietic stem cells. Shilpa Sharma and Gurudutta Gangenahalli* (*Corresponding Author). InternationalJournal of stem cells (Sci Forchen, Korea) 9:36-43, 2016.
9. Electrophoretic detection of alginate by Hematoxylin and Eosin fluorescence: Implications in cell encapsulation/ tissue engineering. Yogesh Verma and Gurudutta Gangenahalli* (*Corresponding Author). Reactive & Functional polymers (Elsevier).) 102, 130–136, 2016.
10. Increased transverse relaxivity in ultrasmall superparamagnetic iron oxide nanoparticles: Applications as MRI contrast agent for biomedical imaging. Sushant Mishra, Subash Kushu and Gurudutta Gangenahalli* (*Corresponding Author). Contrast Media and MolecularImaging (John Wiley& Sons).11(5):350-361. 2016.DOI: 10.1002/cmmi.1698.
11. Conformal coating (encapsulation) of human single cells by biodegradable chitosan nano-particles and their response assessment in vitro and in vivo. Siddharth Pandey, and Gurudutta Gangenahalli * et al. Journal of Pharmaceutics and Drug Delivery(ISSN: 2167-9312), 2,227-234 (2014).American Scientific Publishers). (Impact Factor Awaited in 2016). (*Corresponding Author).
12. Transgene expression study of CXCR4 active mutants: Potential prospects in up-modulation of homing and engraftment efficiency ofhematopoietic stem/progenitor cells. Menka Sharma, Farhat Afrin, Rajendra P Tripathi, Gurudutta Gangenahalli*. Cell Adhesion &Migration (Landes Biosciences) 2014. (Impact Factor 3.4). 10.4161/cam.29285. May 2014. (*Corresponding Author).
13. Human T-Cell line (Jurkat cell) Encapsulation by Nano-organized Polyelectrolytes and their Response Assessment in vitro and in vivo." Siddharth Pandey, GURUDUTTAGangenahalli*, Farhat Afrin et al. Journal of Nanoparticle Research. 15:1793. (Springer). 2013.Impact Factor: 3.29 (2012). (*Corresponding Author).
14. High-throughput transcriptome profiling of bone marrow derived human Mesenchymal stem cells reveal GS3βKinase inhibition as their priming target to stimulate the differentiation towards osteoblastic lineage Neeraj Kumar Satija, Farhat Afrin, R P Tripathi, GURUDUTTAGangenahalli* et al.PLoS1 (USA). 8.1. e55769. 2013. Impact Factor: 4.8 (2012). (*Corresponding Author). ISBN/ISSN No: 1932-6203.
15. Regulated expression of CXCR4 constitutive active mutants’ revealed up-modulated chemotaxis and positive loop of genes crucial for CXCR4 mediated homing and engraftment of hematopoietic stem cells. Menka Sharma, Farhat Afrin, R P Tripathi, GURUDUTTA.Journalof Stem Cell & Regenerative Medicine. 9 .1.19.2013. Impact factor 4.5.(*Corresponding Author).ISBN/ISSN No: 0973-7154.
16. Enhanced hetero-dimerization of Bax by Bcl-2 mutants improves irradiated hematopoietic cell survival. Yogesh Kumar verma, Pawan Kumar, Raghav, H G Raj, GURUDUTTAU Gangenahalli*, et al. Apoptosis (Springer) USA). 2012/DOI 10.1007/s10495-012-0780-8 (nowOnline). Impact Factor: 4:788 (2011). (*Corresponding Author).ISBN/ISSN No: 1360-8185.
17. Molecular Dynamics Simulations of Bcl-2 Protein to Predict the Structure of its Unordered Flexible Loop Domain. Pawan Kumar Raghav, Yogesh Kumar Verma, GURUDUTTA Gangenahalli* et al. Journal of Molecular Modelling (Springer, USA) 18, 5, 1885-1906, 2012.Impact Factor: 1.8(2011). (*Corresponding Author).ISBN/ISSN No.1610-2940. 18. Three dimensional structure Prediction and Interaction of CD34 with Crk-L SH3 Domain. G.U. GURUDUTTA *, Vimal Kishor Singh, Yogesh Verma, Pallavi Gupta, Ramesh Chandra, Shweta Gulati, and Pratibha Mehta Luthra, Stem cells and Development (USA) 14: 2005: 469- 476. Impact Factor: 4.459 (*Corresponding Author).ISBN/ISSN No: 1547-3287. 19. Structural conservation of residues in BH1 and BH2 domains of Bcl-2 family proteins. Gangenahalli U. GURUDUTTA *, Yogesh Kr Verma, Vimal Kishor Singh, Pallavi Gupta, H.G. Raj, R.K. Sharma, Ramesh Chandra. FEBS Letters 579 (17); 2005: 3503-3507.Impact Factor:3.61 (2012) (*Corresponding Author).ISBN/ISSN No: 0014-5793. 20. Evaluation of potential tracer ability of 99mTc-labelled acetylated LDL for scintigraphy of LDL scavenger receptor sites of macrophageal origin. G.U.GURUDUTTA*, A.K.Babbar, Soumya Pati, R.K.Sharma. Nuclear Medicine and Biology (Elsevier, USA). 28(3), 2001. 235- 241. Impact Factor: 3.01 (2011). (*Corresponding Author).ISBN/ISSN No: 0969-8051.
21. Monitoring of the in-situ thymine photo-adduct using UV irradiated DNA antibody F(ab)2 fragment. G.U GURUDUTTA, Chauhan, Viney Jain*, Ramesh Chandra. Bio chem. Soc. Transactions/Communications (London).19.1991. S-4925. Impact Factor-3.71 (2011). (*Corresponding Author).ISBN/ISSN No: 0300-5127.
22. Characterization of glutamine synthetase and ATPases in a mutant strain of the cyanobacterium Nostoc muscorum capable of metabolizing methylamine as a source of nitrogen. G.U. GURUDUTTA, Rita Ghosh, KMR Nambiar and H.N.Singh*. J. Plant. Physiol (Elsevier GmbH).(127. 1987. 323-329. Impact Factor-3.057 (of Average 5 years). (*Corresponding Author).ISBN/ISSN No: 0176-1617.
23. The structural insights of stem cell factor receptor (c-kit) interaction with tyrosine phosphatase-2 (ShP-2): An in silico analysis. Soumya Pati.
G U GURUDUTTAet al.Bio-Med Central Research Notes. (BMC) (USA) (Open Access). 3:14-43. 2010. Impact Factor: Available in 2013 (See the letter attached from BMC office). (* Corresponding Author). ISBN/ISSN No: 1756-0500.
24. Antigenic manifestation of the free and intact UV (250nm) irradiated deoxyribonucleic acid. Ramesh Chandra,G.U. GURUDUTTA*, UPS Chauhan. Clin. Chem. Enzy. Comm. (Harwood Academic Publishers, Amsterdam/Netherlands).7. 1997. 317-330. *CorrespondingAuthor).Impact Factor-Not Available.ISBN/ISSN No: 0892-2187.
25. Hematopoietic stem cell antigen CD34: role in adhesion or homing. G.U. GURUDUTTA *, vimal kishor singh, Yogesh Verma, Pallavi Gupta, Ramesh Chandra, Shweta Gulati, and Pratibha Mehta Luthra, Stem cells and Development (USA): 15;2006: 305-313. Impact Factor:4.459 (*Corresponding Author).ISBN/ISSN No: 1547-3287.