Kathleen E Bethin

Clinical Associate Professor


Kathleen Bethin, MD, PhDearned her MD and PhD from the University at Buffalo School of Medicine. She completed her Pediatric Residency and Pediatric Endocrinology Fellowship at Washington University in St. Louis, MO. She was Assistant Professor of Pediatrics at Indiana University School of Medicine before coming to Buffalo in 2008. She is currently Associate Professor of Pediatrics at the University at Buffalo. She is Program Director for the Pediatric Endocrinology Fellowship at the University at Buffalo. Sheholds board certifications in Pediatrics and Pediatric Endocrinology and Diabetes from the American Board of Pediatrics. She is a member of the Section of Endocrinology of the American Academy of Pediatrics, Pediatric Endocrine Society, Endocrine Society and American Diabetes Association. She is a board member of the WNY Juvenile Diabetes Research Foundation and medical advisor to the Childrens Growth Foundation. She is active in research and clinical care. She is the local principal investigator of the Type 1 Diabetes Exchange. Her clinical research interests include obesity, Types 1 and 2 diabetes.


Area of Interest

Pediatric Research Endocrine, Diabetes, Adrenal Insufficiency, obesity, Types 1 and 2 diabetes

top publication

1. Palida, F., Mas, A., Arola, L., Lonergan, P.A., Bethin, K. and Ettinger, M.J. Cytosolic Copper-Binding Proteins in Rat and Mouse Hepatocytes Incubated Continuously with Cu (II). Biochem. J. 268: 359-366 (1990).
2. Bethin, K.E., Cimato, T.R. and Ettinger, M.J. Copper Binding to Mouse Liver S-Adenosylhomocysteine Hydrolase and the Effects of Copper on Its Levels. J. Biol. Chem. 270: 20703-20711 (1995).
3. Bethin, K.E., Petrovic, N. and Ettinger, M.J. Identification of a Major Hepatic Copper Binding Protein as S-Adenosylhomocysteine Hydrolase. J. Biol. Chem. 270: 20698-20702 (1995).
4. Bethin, K.E., Vogt, S.K. and Muglia, L.M.. Interleukin-6 is an Essential, Corticotropin-Releasing Hormone-Independent, Stimulator of the Adrenal Axis during Immune System Activation. PNAS. 97: 9317-9322 (2000).
5. Brewer JA, Bethin KE, Schaefer ML, Muglia LM, Vogt SK, Weninger SC, Majzoub JA, Muglia LJ. Dissecting adrenal and behavioral responses to stress by targeted gene inactivation in mice. Stress. 6(2): 121-5 (2003).
6. Bethin KE, Nagai Y, Sladek R, Asada M, Sadovsky Y, Hudson TJ, Muglia LJ. Microarray Analysis of Uterine Gene Expression in Mouse and Human Pregnancy. Mol Endocrinol. 17: 1454-1469 (2003); first published May 29 2003 as doi:10.1210/me.2003-0007.
7. Vachharajani A, Bethin K, Mouillet JF, Sadovsky Y, Saunders S. The rare occurrence of absent adrenals in a term infant: a case report and review of the literature. Am J Perinatol: 23(2):111-4 (2006).
8. Zhao B, Koon D, Bethin KE. Identification of Transcription Factors at the Site of Implantation in the Later Stages of Murine Pregnancy. Reproduction. Mar;131(3):561-71, (2006).
9. Wagoner HA, Steinmetz R, Bethin KE, Eugster EA, Pescovitz OH, Hannon TS. GNAS Mutation Detection is Related to Disease Severity in Girls with McCune-Albright Syndrome and Precocious Puberty. Pediatr Endocrinol Rev. Aug; 4 (Suppl 4): 395-400, (2007).
10. Zhao B, Koon D, Curtis AL, Soper J, Bethin KE. Identification of 9 uterine genes that are regulated during mouse pregnancy and exhibit abnormal levels in the cyclooxygenase-1 knockout mouse. Reprod Biol Endocrinol: 5(1):28, (2007).
11. Yao W, Bethin K, Yang X, Zhong J, Lee W-H. Role of the GH/IGF-I Axis in the Growth Retardation of Weaver Mice. Endocrine. 32:227-34, (2007).
12. Majumdar, I., Bethin, K. and Quattrin, T. Weight trajectory of youth with new-onset type 1 diabetes comparing standard and enhanced dietary education. Endocrine. DOI 10.1007/s12020-014-0469-6.
13. Davis, AK , DuBose, SN, Haller, MJ, Miller, KM, DiMeglio, LA, Bethin, KE, Goland, RS, Greenberg, EM, Liljenquist, DR, Ahmann, AJ, Marcovina, SM, Peters, AL, Beck, RW and Greenbaum, CJ, for the T1D Exchange Clinic Network. Prevalence of Detectable C-Peptide According to Age at Diagnosis and Duration of Type 1 Diabetes Diabetes Care. In Press.