Nihar Ranjan Nayak

Associate Professor



Nihar R. Nayak, DVM, PhD, is an Associate Professor in the Department of Obstetrics and Gynecology at the Wayne State University School of Medicine. Dr. Nayak has extensive research experience in the field of reproductive biology, particularly on endometrial physiology, implantation, placentation, and pathophysiology of pregnancy diseases.His current research is focused on the mechanisms of angiogenesis and vascular remodeling during pregnancy, with emphasis on various vascular complications during pregnancy, including preeclampsia.


Area of Interest

1.Endometrial angiogenesis and bleeding.
5.Placental function.
6.Vascular complications during pregnancy.

top publication

1. Fan, X., Pettit, M., Gamboa, M., Huang, M., Dhal, S., Druzin, M.L., Wu, J.C., Chen-Tsai, Y. and Nayak, N.R. (2012) Transient, inducible, placenta-specific gene expression in mice. Endocrinology, 153(11):5637-44.

2. Fan, X., Kambham, N., Sung, J.F., Singh, N., Petitt, M., Dhal, Sutton, R.E., Druzin, M.L., Gambhir, S.S., Ambati, B.K., and Nayak, N.R. (2013) Placental sFlt-1 production is essential for normal pregnancy. JCI, submitted.

3. Fan, X., Kreig, S., Hwang, J.Y., Dhal, S., Kuo, C.J., Lasley, B.L., Brenner, R.M., and Nayak, N.R. (2012) Dynamic regulation of Wnt7a expression in the primate endometrium: implications for postmenstrual regeneration and secretory transformation. Endocrinology, 153(3):1063-9.

4. Fan, X., Ren, P., Dhal, S., Bejerano, G., Goodman, S.B., Druzin, M.L., Gambhir, S.S. and Nayak, N.R. (2011) Noninvasive Monitoring of Placenta-Specific Transgene Expression by Bioluminescence Imaging. PLoS ONE, 6(1):e16348.

5. Sung, J.F., Fan, X., Dhal, S., Dwyer, B., Jafari, A., El-Sayed, Y.Y., Druzin, M.L. and Nayak, N.R. (2011) Decreased Circulating Soluble Tie2 Levels in Preeclampsia May Result from Inhibition of Vascular Endothelial Growth Factor (VEGF) Signaling. J Clin Endocrinol Metab, 96 (7):E1148-52.

6. Krieg, S.A., Fan, X., Krieg, A.J., Giaccia, A., Westphal, L.M., Lathi, R.B. and Nayak, N.R. (2012) Differential Gene Regulation in the Decidua of Women with Idiopathic Recurrent Pregnancy Loss. Mol Hum Reprod, 18(9):442-50.

7. Fan, X., Kreig, S., Kuo, C.J., Wiegand, S.J., Rabinovitch M., Druzin, M., Brenner, R.M., Giudice, L.C., and Nayak, N.R. (2008) VEGF blockade inhibits angiogenesis and postmenstrual reepithelization of endometrium. FASEB J, 22(10):3571-80.

8. Kuhnert F, Tam BY, Sennino B, Gray JT, Yuan J, Jocson A, Nayak NR, Mulligan RC, McDonald DM, Kuo CJ (2008) Soluble receptor-mediated selective inhibition of VEGFR and PDGFR{beta} signaling during physiologic and tumor angiogenesis. Proc Natl Acad Sci U S A, 105(29):10185-90.

9. Tam BY, Wei K, Rudge JS, Hoffman J, Holash J, Park SK, Yuan J, Hefner C, Chartier C, Lee JS, Jiang S, Nayak NR, Kuypers FA, Ma L, Sundram U, Wu G, Garcia JA, Schrier SL, Maher JJ, Johnson RS, Yancopoulos GD, Mulligan RC, Kuo CJ. (2006) VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis. Nature Medicine, 12:793-800.

10. Dwyer, B., Kreig, S., Balise, R., Chueh, J., Nayak, N.R., and Druzin, M (2010) Variable expression of soluble fms-like tyrosine kinase 1 in patients at high risk for preeclampsia. J Matern Fetal Neonatal Med, 23:705-11.

11. Zhao, H., Wong, R.J., Kalish, F., Nayak, N.R. and Stevenson, D.K. (2009) Effect of heme oxygenase-1 deficiency on placental development. Placenta 30(10):861-8. 12. Chennazhi KP and Nayak NR (2009) Regulation of angiogenesis in the primate endometrium: vascular endothelial growth factor. Semin Reprod Med, 27(1):80-9.

13. Nayak, N.R., Slayden, O.D., Mah, K., Chwalisz, K., Lehtinen, M. and Brenner, R.M. (2007) Antiprogestin-releasing intrauterine devices: a novel approach to endometrial contraception. Contraception, 75:S104-11.

14. Nayak, N.R., Kuo, C.J., Desai, T.A., Wiegand, S.J., Lasley, B.L., Giudice, L.C. and Brenner, R.M. (2006) Expression, localization and hormonal control of angiopoietin-1 in the rhesus macaque endometrium: potential role in spiral artery growth. Molecular Human Reproduction, 11:791-799.

15. Germeyer, A., Hamilton, A.E., Laughlin, L.S., Lasley, B.L., Brenner, R.M., Giudice, L.C.and Nayak, N.R. (2005) Cellular expression and hormonal regulation of neuropilin-1 and -2 mRNA in the human and rhesus macaque endometrium. J Clin Endocrinol Metab, 90:1783-1790.

16. Zhao, H., Wong, R.J., Doyle, T.C., Nayak, N.R., Vreman, H.J., Contag, C.H. and Stevenson, D.K. (2008) Regulation of maternal and fetal hemodynamics by heme oxygenase in mice. Biology of Reproduction, 78:744-51.

17. Yang Q, El-Sayed Y, Rosenberg-Hasson Y, Hirschberg DL, Nayak NR, Schilling J, Yu TT and Madan A (2009) Multiple cytokine profile in plasma and amniotic fluid in a mouse model of preterm labor. . Am J Reprod Immunol, 62(5):339-47.

18. Yang Q, Whitin JC, Ling XB, Nayak N, Cohen HJ, Jin J, Schilling J, Yu TT and Madan A (2009) Plasma biomarkers in a mouse model of preterm labor. Pediatr Res, 66(1):11-6.

19. Nyegaard, M., Overgaard, M.T., Su, Y-Q., Hamilton, A.E., Kwintkiewitz, J., Hsieh, M., Nayak, N.R., Conti, M., Conover, C.A. and Giudice, L.C. (2010) Lack of Functional Pregnancy-Associated Plasma Protein-A (PAPP-A) Compromises Ovarian Steroidogenesis and Female Fertility. Biol Reprod, 82(6):1129-38.

20. Hess AP, Hamilton A, Talbi S, Dosiou C, Nyegaard M, Nayak NR, Genbecev-Krtolica O, Mavrogianis P, Ferrer K, Kruessel J, Fazleabas AT, Fisher SJ, and Giudice LC (2007) Decidual stromal cell response to paracrine signals from the trophoblast: Amplification of immune and angiogenic modulators. Biol Reprod, 76:102-17.

21. Talbi S, Hamilton AE, Vo KC, Tulac S, Overgaard MT, Dosiou C, Le Shay N, Nezhat CN, Kempson R, Lessey BA, Nayak NR, Giudice LC (2006) Molecular phenotyping of human endometrium distinguishes menstrual cycle phases and underlying biological processes in normo-ovulatory women. Endocrinology, 147:1097-1121.

22. Hess, A.P., Nayak, N.R. and Giudice, L.C. (2006) Cyclic Changes in the Primate Oviduct and Endometrium. In: Knobil and Neill’s Physiology of Reproduction (Neill JD, 3rd edition), Elsevier, New York, pp 337-381.

23. Lathi, R.B., Hess, A.P., Tulac, S., Nayak, N.R., Conti, M. and Giudice, L.C. (2005) Dose-dependent insulin regulation of IGFBP-1 in human endometrial stromal cells is mediated by distinct signaling pathways. J Clin Endocrinol Metab, 90:1599-1606.

24. Lobo, S.C., Huang, J., Vo, K.C., Germeyer, A., Tulac, S., Nayak, N.R. and Giudice, L.C. (2004) The immune environment in the human endometrium during the window of implantation. Am J Reprod Immunol, 52:244-251.

25. Tulac, S., Nayak, N.R., Kao, L.C., van Waes, M., Huang, J, Lessey, B.A., Taylor, R.N., Suchanek, E., Giudice, L.C. (2003) Identification, characterization and regulation of the canonical Wnt signaling pathway in human endometrium. J Clin Endocrinol Metab, 88, 3860-3866.