Dr. Sabry M. Attia is a Professor in College of Pharmacy, KSU, Saudi Arabia. He received his Ph.D. in Genetics at Technical University of Munich, Germany in 2004. Dr. Attia also has worked as a postdoctoral research associate at GSF-Institute of Experimental Genetics and as a postdoctoral fellowship at Helmholtz Zentrum München-Genome Analysis Center, Germany. This period of research was concerned with developing new approaches for drug screening, toxicants detection and prevention. During his scientific career, Dr. Attia has developed an expertise in several advanced techniques and research protocols related to Molecular pharmacology and toxicology. Dr. Attia has more than fifty publications in peer-reviewed international journals. Dr. Attia was awarded “State Prize for Encouragement of Scientific Research”Â in Medical Sciences, the Academy of Scientific Research and Technology, Cairo, Egypt, 2010 and the second prize for the best 2 presentations at the Anticancer Drug Conference 2011, Stockholm, Sweden, 2011.
The major components of my research interests are: ïƒ˜ Development and evaluate methods for detection of genotoxicants. ïƒ˜ Characterisation of the mechanism of action of genotoxicants. ïƒ˜ Determination of the no observable effect levels and dose-response relationships of genotoxicants in mammalian cells. ïƒ˜ Determination of the influence of cell cycle checkpoint genes such as p53 upon the induction of DNA damage and mechanisms of action. ïƒ˜ Analysis of the influence of apoptosis induced by genotoxicants upon dose-response relationships. ïƒ˜ Characterisation of the role of mutations in tumour induction and progression and in the production of birth abnormalities and secondary tumours. ïƒ˜ Comparative analysis of the dose-response relationships of genotoxicants in both somatic and male germ cells. ïƒ˜ Analysis of rates of transmission of aneugenic damage in rodent embryos. ïƒ˜ Identification of potential biomarkers of exposure to genotoxicants. ïƒ˜ Other areas include synthesis and biological evaluation of some novel therapeutic drugs and instrumental analysis of drugs in biological fluids by various techniques including; HPLC, capillary electrophoresis, spectrophotometry and flow cytometry.
1. Ahmad SF, Attia SM, Zoheir KM, Ashour AE, Bakheet SA. (2014). Poly(ADP-ribose) polymerase-1 inhibitor modulates T regulatory and IL-17 cells in the prevention of adjuvant induced arthritis in mice model. Cytokine. Impact Factor: 3.121
2. Harisa GI, Attia SM, Ashour AE, Abdallah GM, Omran GA, Touliabah HE. (2014). Cigarette Smoking and Hyperglycemia Increase Renal Response to Low Levels of Cadmium in Welders: Cystatin C as a Sensitive Marker. Biological Trace Element Research. Accepted. Impact Factor: 1.307
3. Alanazi AM, Hefnawy MM, Al-Majed AA, Al-Suwailem AK, Kassem MG, Mostafa GA, Attia SM, Khedr MM. HPLC-Fluorescence Method for the Enantioselective Analysis of Propranolol in Rat Serum Using Immobilized Polysaccharide-Based Chiral Stationary Phase. Chirality. 2014 Mar 3. doi: 10.1002/chir.22296. [Epub ahead of print] Impact Factor: 1.894
4. Ahmad SF, Zoheir KM, Abdel-Hamied HE, Alrashidi I, Attia SM, Bakheet SA, Ashour AE, Abd-Allah AR. (2014). The role of a histamine 4 receptor as an anti-inflammatory target in carrageenan-induced pleurisy in mice. Immunology. doi: 10.1111/imm.12257. Impact Factor: 3.705
5. Abd-Allah AR, Ahmad SF, Alrashidi I, Abdel-Hamied HE, Zoheir KM, Ashour AE, Bakheet SA, Attia SM. (2014). Involvement of histamine 4 receptor in the pathogenesis and progression of rheumatoid arthritis. Int Immunol. 2014 Jan 8. [Epub ahead of print]. Impact Factor 3.135
6. Ashour AE, Abd-Allah AR, Korashy HM, Attia SM, Alzahrani AZ, Saquib Q, Bakheet SA, Abdel-Hamied HE, Jamal S, Rishi AK. (2014). Thymoquinone suppression of the human hepatocellular carcinoma cell growth involves inhibition of IL-8 expression, elevated levels of TRAIL receptors, oxidative stress and apoptosis. Mol Cell Biochem. 389(1-2):85-98. Impact Factor 2.329
7. Ahmad SF, Attia SM, Zoheir KM, Ashour AE, Bakheet SA. (2014). Attenuation of the progression of adjuvant-induced arthritis by 3-aminobenzamide treatment. Int. Immunopharmacol., 19; 52-59. Impact Factor: 2.417
8. Ahmad SF, Zoheir KMA, Abdel-Hamied HE, Ashour AE, Bakheet SA, Attia SM, Abd-Allah AR (2014). Amelioration of autoimmune arthritis by naringin through modulation of T regulatory cells and Th1/Th2 cytokines. Cellular Immunology, 287; 112-120. Impact Factor 1.743
9. Hefnawy MM, Alanazi AM., Abounassif MM, Mohammed MS, Attia SM, Mostafa GAE, (2014). Validated liquid chromatographic-fluorescence method for the quantitation of darifenacin in mice plasma and its application to a pharmacokinetic study. Talanta 121. 37-42. Impact Factor 3.498
10. Ahmad SF, Attia SM, Bakheet SA, Ashour AE, Zoheir KM, Abd-Allah AR. (2014). Anti-inflammatory effect of Euphorbia hirta in an adjuvant-induced arthritic murine model. Immunol Invest., 43(3):197-211. Impact Factor 1.731
11. Ahmad SF, Zoheir KM, Abdel-Hamied HE, Attia SM, Bakheet SA, Ashour AE, Abd-Allah AR. (2014). Grape seed proanthocyanidin extract protects against carrageenan-induced lung inflammation in mice through reduction of pro-inflammatory markers and chemokine expressions. Inflammation. 37(2):500-11. Impact Factor 2.457
12. Attia SM, Ahmad SF, Zoheir KM, Bakheet SA, Helal GK, Abd-Allah AR, Al-Harbi NO, Al-Hosaini KA, Al-Shabanah OA (2014). Genotoxic evaluation of chloroacetonitrile in murine marrow cells and effects on DNA damage repair gene expressions. Mutagenesis. 29, 55-62. Impact Factor 3.5
13. Harisa GI, Mariee AD, Abo-Salem OA, Attiaa SM. (2013). Erythrocyte nitric oxide synthase as a surrogate marker for mercury-induced vascular damage: the modulatory effects of naringin. Environ Toxicol. DOI: 10.1002/tox.21862. Impact Factor 2.708
14. Attia SM, Ahmad SF, Abd-Ellah MF, Hamada FM, Bakheet SA (2013). Germ cell mutagenicity of topoisomerase I inhibitor topotecan detected in the male mouse-dominant lethal study. Food Chem Toxicol. 62C, 470-474. Impact Factor 3.01
15. Attia SM, Harisa GI, Hassan MH, Bakheet SA (2013). Beryllium chloride induced oxidative DNA damage and alteration in the expression patterns of DNA repair-related genes. Mutagenesis 28(5): 555-559. Impact Factor 3.5
16. Attia SM, Ahmad SF, Harisa GI, Mansour AM, El Sayed EM, Bakheet SA (2013). Wogonin attenuates etoposide-induced oxidative DNA damage and apoptosis via suppression of oxidative DNA stress and modulation of OGG1 expression. Food Chem Toxicol. 59C: 724-730. Impact Factor 3.01
17. Ahmad SF, Zoheir KM, Abdel-Hamied HE, Ashour AE, Bakheet SA, Attia SM, Abd-Allah AR. (2013). Grape seed proanthocyanidin extract has potent anti-arthritic effects on collagen-induced arthritis by modifying the T cell balance. Int Immunopharmacol., 17(1):79-87. Impact Factor 2.417
18. Attia SM, Harisa GI, Abd-Allah AR, Ahmad SF, Bakheet SA (2013). The influence of lentinan on the capacity of repair of DNA damage and apoptosis induced by paclitaxel in mouse bone marrow cells. J Biochem Mol Toxicol. 27(7):370-377. Impact Factor 1.596
19. Attia SM, Ashour AE, Bakheet SA. (2013). Comet-FISH studies for evaluation of genetic damages of citalopram in somatic cells of the mouse. J Appl Toxicol. 33(9):901-905. Impact Factor 2.597
20. Attia SM, Bakheet SA. (2013). Effect of dihydrokainate on the capacity of repair of DNA damage and apoptosis induced by doxorubicin. Mutagenesis 28(3):257-261. Impact Factor 3.5
21. Ahmad SF, Bani S, Sultan P, Ali SA, Bakheet SA, Attia SM, Abd-Allah AR. (2013). TNF-α inhibitory effect of Euphorbia hirta in rats. Pharm Biol. 51(4):411-417. Impact Factor 1.206
22. Attia SM, Bakheet SA. (2013). Citalopram at the recommended human doses after long-term treatment is genotoxic for male germ cell. Food Chem Toxicol. 53: 281-285. Impact Factor 3.01
23. Fayaz Ahmad S, Khan B, Bani S, Kaul A, Sultan P, Abid Ali S, Satti NK, Bakheet SA, Attia SM, Zoheir KMA, Abd-Allah AR. (2013). Immunosuppressive effects of Euphorbia hirta in experimental animals. Inflammopharmacol 21(2):161-168.
24. Attia SM. (2013). Molecular cytogenetic evaluation of the mechanism of genotoxic potential of amsacrine and nocodazole in mouse bone marrow cells. J Appl Toxicol. 33(6):426-433. Impact Factor 2.597
25. Fayaz Ahmad S, Sultan P, Ashour AE, Khan TH, Attia SM, Bakheet SA, Abd-Allah AR. (2013). Modulation of Th1 cytokines and inflammatory mediators by Euphorbia hirta in animal model of adjuvant-induced arthritis. Inflammopharmacology 21(5):365-375.